Prospective study of association between high plasma fetuin-A levels and incident ischemic stroke

• Project/Area Number: 23590828
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Public health/Health science
• Research Institution: Kurume University
• Principal Investigator: ADACHI HISASHI 久留米大学, 医学部, 教授 (40212518)
• Co-Investigator(Kenkyū-buntansha): HIRAI Yuji 久留米大学, 医学部, 講師 (70309780)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 疫学 / フェチュインA / 脳卒中 / メタボリック症候群 / 地域住民 / 虚血性脳梗塞 / インスリン抵抗性 / 心筋梗塞

Research Abstract

Whatever the mechanisms are, elevations of fetuin-A were associated with metabolic syndrome and hypercholesterolemia, which are strong risk factors for cerebro-cardiovascular diseases. In fact, many clinical studies reported a high incidence of cerebro-cardiovascular diseases in subjects with high fetuin-A levels.
We prospectively investigated that higher fetuin-A levels are related to incident ischemic stroke in our cohort, and we also elucidated the significance of plasma fetuin-A as a risk factor of the stroke in a general Japanese cohort.

Research Products

• [Journal Article] High plasma fetuin-A levels are associated with metabolic syndrome among males but not females in a Japanese general population (2014)
  • Author(s): Obuchi A, Adachi H, et al
  • Journal Title: Diab Res Clin Pract Volume: (in press)
  • Peer Reviewed
• [Presentation] Plasma fetuin-A levels are associated with insulin resistance in a general population in Uku-town (2014)
  • Author(s): Obuchi A, Adachi H, et al
  • Organizer: 第79回日本循環器学会総会学術集会
  • Place of Presentation: 東京都
  • Year and Date: 2014-03-22
• [Presentation] Plasma fetuin-A levels are associated with insulin resistance in a general population in Uku-town. (2014)
  • Author(s): Obuchi A, Adachi H, et al.
  • Organizer: 第79回日本循環器学会総会学術集会
  • Place of Presentation: 東京都
• [Presentation] 血清フェチュインAとインスリン抵抗性との関連、一般住民における疫学的検討 (2013)
  • Author(s): 大渕綾, 足達寿, 他
  • Organizer: 第49回日本循環器病予防学会
  • Place of Presentation: 金沢市
  • Year and Date: 2013-06-14
• [Presentation] 血清フェチュインA値とインスリン抵抗性との関連：一般住民検診における疫学的検討 (2013)
  • Author(s): 大渕 綾、足達 寿、他
  • Organizer: 第49回日本循環器病予防学会
  • Place of Presentation: 金沢市
• [Presentation] Plasma fetuin-A levels is associated with insulin resistance in a general population. (2012)
  • Author(s): Aya Obuchi, Hisashi Adachi, et al.
  • Organizer: 22st European meeting on hypertension and cardiovascular prevention
  • Place of Presentation: London, England
• [Presentation] Serum fetuin-A levels are inversely associated with carotid plaque in a population of community-dwelling Japanese. (2012)
  • Author(s): Aya Obuchi, Hisashi Adachi, et al.
  • Organizer: The Asia Pacific Stroke Conference
  • Place of Presentation: Tokyo, Japan
• [Presentation] 血清フェチュインA高値は、インスリン抵抗性と関連するか？ (2012)
  • Author(s): 大渕 綾、足達 寿
  • Organizer: 第７６回日本循環器学会総会
  • Place of Presentation: 福岡市