| Project/Area Number |
23590841
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Legal medicine
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| Research Institution | Asahikawa Medical College |
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Principal Investigator |
SHIMIZU KEIKO 旭川医科大学, 医学部, 教授 (90312462)
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| Co-Investigator(Kenkyū-buntansha) |
MATSUBARA Kazuo 京都大学, 医学(系)研究科(研究院), 教授 (20127533)
MASEDA Chikatoshi 旭川医科大学, 医学部, 准教授 (50550555)
ASARI Masaru 旭川医科大学, 医学部, 助教 (40360979)
OMURA Tomohiro 京都大学, 医学(系)研究科(研究院), 助教 (00439035)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 凍死 / 低温環境ストレス / CIRP / RBM3 / 法医診断 |
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| Research Abstract |
No specific findings of death induced by hypothermia have been reported, although autopsies have accordingly been performed. Practically, a diagnosis of fatal hypothermia cases is established by exclusion of other known causes of death (e.g. injury, poisoning and disorder) and by relatively characteristic findings (e.g. difference in color between right and left heart blood samples, first degree frostbite, Wischnewski's spots in gastroduodenal submucous, and paradoxical undressing). It is important for finding diagnostic markers to identify the pathophysiological and molecular processes of hypothermia-induced deaths. CIRP (cold-inducible RNA-binding protein)and RBM3(RNA binding motif protein 3)are two major cold-inducible RNA-binding proteins, which are rapidly induced in human cells on exposure to moderate cold-shock. Our results suggest that immunohistochemical examinations of CIRP and RBM3 may be useful for the diagnosis of various unusual deaths in hypothermal environments.
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