• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Evaluation of human vascular wall tissue fragility

Research Project

Project/Area Number 23590844
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Legal medicine
Research InstitutionKanazawa University

Principal Investigator

ZUKA Masahiko  金沢大学, 医学系, 講師 (00272956)

Co-Investigator(Kenkyū-buntansha) OHSHIMA Tohru  金沢大学, 医学系, 教授 (40183024)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Keywords動脈硬化 / プロテアーゼ / ゼラチナーゼ / 血管 / 血管壁脆弱性 / 病理組織学
Research Abstract

With regard to more than 100 cases subjected to forensic autopsy between 2011-2013, gelatinase degrading activity was investigated in aorta, carotid and cerebral arteries and choroid plexus tissue samples in addition to serum and cerebrospinal fluid. In forensic autopsies of initially unidentified cases in which subsequently identity was established, aorta and coronary artery diffuse intimal thickening and tissue gelatinolytic activity were found to be useful in the determination of age. From the viewpoint of vascular wall tissue fragility, we histologically investigated the frequency of unexamined secondary aldosteronism, a cause of hypertension and recognized risk factor for vascular lesions, and based on our findings raised an alarm that sufficient attention is not being paid to this important issue. In animal experiments, based on the contention that vascular diffuse intimal thickening represents one type of fibrosis, analysis using an autoimmune disease model mouse was conducted.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (13 results)

All 2014 2013 2012 2011 Other

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (8 results) Book (3 results)

  • [Journal Article] Tracheal injury added to cervical bone destruction due to the impact of hitting the water surface: Four immersed adult bodies.2013

    • Author(s)
      Zuka M, Ohshima T.
    • Journal Title

      Forensic Sci Int

      Volume: 228 Issue: 1-3 Pages: e62-e66

    • DOI

      10.1016/j.forsciint.2013.02.009

    • Related Report
      2013 Annual Research Report 2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Fatal and non-fatal cases of lime sulfide exposure and pathogenetic mechanisms underlying pancreatic injury : Case reports with an animal experiment2012

    • Author(s)
      Zuka M, Chinaka S, Matsumoto Y, Takayama N, Hitomi Y, Nakamura H, Ohshima T
    • Journal Title

      J Forensic Leg Med

      Volume: 19(6) Issue: 6 Pages: 358-362

    • DOI

      10.1016/j.jflm.2012.02.027

    • Related Report
      2013 Final Research Report 2012 Research-status Report 2011 Research-status Report
    • Peer Reviewed
  • [Presentation] Inhibition of APRIL suppresses disease progression : Analysis from a novel mouse model for IgG4-realted disease2014

    • Author(s)
      Yamada K, Zuka M, Ito K, Suzuki Y, Kakuchi Y, Onoe T, Yamagishi M, Kawano M
    • Organizer
      International symposium- IgG4RD & associated conditions
    • Place of Presentation
      Sheraton Waikiki Hotel, Honolulu, U.S.A
    • Year and Date
      2014-02-18
    • Related Report
      2013 Final Research Report
  • [Presentation] 副腎良性腫瘍を伴っていた自殺の2事例2013

    • Author(s)
      塚正彦, 大島徹
    • Organizer
      第97次日本法医学会学術集会
    • Place of Presentation
      北海道札幌市ロイトン札幌
    • Year and Date
      2013-06-28
    • Related Report
      2013 Final Research Report
  • [Presentation] 同一家屋内での異状死を契機として同居人の健康が損なわれた2例2012

    • Author(s)
      塚正彦, 大島徹
    • Organizer
      第96次日本法医学会学術集会
    • Place of Presentation
      静岡県浜松市アクトシティ浜松
    • Year and Date
      2012-06-08
    • Related Report
      2013 Final Research Report
  • [Presentation] ビニール袋を被り窒息死した2事例2011

    • Author(s)
      塚正彦, 大島徹
    • Organizer
      第95次日本法医学会学術集会
    • Place of Presentation
      福島県福島市コラッセ福島
    • Year and Date
      2011-06-16
    • Related Report
      2013 Final Research Report
  • [Presentation] 副腎良性腫瘍を伴っていた自殺の2事例

    • Author(s)
      塚 正彦、大島 徹
    • Organizer
      第97次日本法医学会学術全国集会
    • Place of Presentation
      ロイトン札幌、北海道札幌市
    • Related Report
      2013 Annual Research Report
  • [Presentation] Inhibition of APRIL suppresses disease progression: Analysis from a novel mouse model for IgG4-related disease

    • Author(s)
      Yamada K, Zuka M, Ito K, Suzuki Y, Kakuchi Y, Onoe T, Yamagishi M, Kawano M
    • Organizer
      International symposium - IgG4-RD & associated conditions
    • Place of Presentation
      Sheraton Waikiki Hotel, Honolulu, USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] 同一家屋内での異状死を契機として同居人の健康が損なわれた2例

    • Author(s)
      塚 正彦
    • Organizer
      第96次日本法医学会学術全国集会
    • Place of Presentation
      アクトシティ浜松、静岡県浜松市
    • Related Report
      2012 Research-status Report
  • [Presentation] ビニール袋を被り窒息死した2事例

    • Author(s)
      塚 正彦 他
    • Organizer
      日本法医学会総会
    • Place of Presentation
      福島県福島市、コラッセ福島
    • Related Report
      2011 Research-status Report
  • [Book] 集中講義医事法学・法医学2012

    • Author(s)
      塚正彦, 大島徹他
    • Publisher
      メジカルビュー
    • Related Report
      2013 Final Research Report
  • [Book] 医事法学・法医学2012

    • Author(s)
      塚 正彦 他 編集:寺野彰・一杉正仁
    • Total Pages
      6
    • Publisher
      メジカルビュー社
    • Related Report
      2012 Research-status Report
  • [Book] 医事法学・法医学2012

    • Author(s)
      塚 正彦 他(分担)
    • Total Pages
      6
    • Publisher
      メジカルビュー
    • Related Report
      2011 Research-status Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi