Comprehensive analysis for biological toxicity with synthetic narcotic MDMA
| Project/Area Number |
23590845
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Legal medicine
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2013
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 合成麻薬 / MDMA / 毒性 / 遺伝子 / 多因子解析 / 覚せい剤 / 覚醒剤 |
|---|
| Research Abstract |
MDMA is a synthetic narcotic, which is resembled to methamphetamine (MA) structure. The aim of this study is clear the differences of biological functions from MDMA and MA. MDMA and MA were separately injected to mice once two days during 51 days as well as saline for a blank experiment. Mice weights for MDMA or MA were decreased to those of a blank group for 10-20 days. Then mice weights for MDMA and MA were increased same rate as the blank group. Comprehensive mRNA analyses with the brain and heart showed changes of metabolic factors for lipids and fatty acids, cytokines, transcription factors, translations factors, and others. These results are fundamental to the next experiment.
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Report
(4 results)
Research Products
(3 results)
