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Study of the mechanizum of acute encephalopathy caused by cyanogenic mushroom

Research Project

Project/Area Number 23590848
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Legal medicine
Research InstitutionHamamatsu University School of Medicine

Principal Investigator

GONMORI Kunio  浜松医科大学, 医学部, 特任研究員 (10006744)

Co-Investigator(Kenkyū-buntansha) SUZUKI Osamu  浜松医科大学, 医学部, 理事 (70093044)
WATANABE Kanako  浜松医科大学, 医学部, 教授 (70288546)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2013: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000)
Fiscal Year 2012: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2011: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Keywordsきのこ中毒 / 急性脳症 / 青酸 / スギヒラタケ / 培養 / 質量分析 / 代謝
Research Abstract

In autumn 2004, 59 cases of acute encephalopathy were reported across 9 prefectures in Japan.We concluded that encephalopathy experienced caused by was the cyanogenic mushroom.We study the mechanism of the acute encephalopathy by cyanogenic mushroom, Pleurocybella porrigens. For three years from 2011, we collect the mushrooms at a same point.But the occureence of mushroom is not enough except 2012 by unseasonable weather.It is difficult to study with natural materials is affected by the environment such as weather. We tried to artificial cultivation the Pleurocybella porrigens.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (16 results)

All 2013 2012 2011

All Journal Article (9 results) (of which Peer Reviewed: 4 results) Presentation (7 results)

  • [Journal Article] Determination of ibotenic acid and muscimol, the Amanita mushroom toxins, in human serum by liquid chromatography-tandem mass spectrometry2013

    • Author(s)
      Hasegawa K, Gonmori K, Fujita H, Kamijo Y, Nozawa H, Yamagishi I, Minakata K, Watanabe K, Suzuki O
    • Journal Title

      Forensic Toxicology

      Volume: 31 Issue: 2 Pages: 322-327

    • DOI

      10.1007/s11419-013-0189-2

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Analysis of ibotenic acid and muscimol in Amanita mushrooms by hydrophilic interaction liquid chromatography-tandem mass spectrometry2012

    • Author(s)
      Gonmori K, Hasegawa K, Fujita H, Kamijo Y, Nozawa H, Yamagishi I, Minakata K,Watanabe K, Suzuki O
    • Journal Title

      Forensic Toxicology

      Volume: 30(2) Pages: 168-172

    • Related Report
      2013 Final Research Report
  • [Journal Article] MALDI-TOF mass spectrometric analysis ofα-amanitin,β-amanitin, and phalloidin in urine2012

    • Author(s)
      Gonmori K, Minakata K, Suzuki M, Yamagishi I, Nozawa H, Hasegawa K, Wurita A,Watanabe K, Suzuki O
    • Journal Title

      Forensic Toxicology

      Volume: 30(2) Pages: 179-184

    • Related Report
      2013 Final Research Report
  • [Journal Article] A new approach in tandem mass spectrometric simultaneous determination of perchlorate, thiocyanate, and iodide using their ternary complexes with tris(1,10-phenanthroline)iron(II) chelate2012

    • Author(s)
      Minakata K, Nozawa H, Yamagishi I, Gonmori K, Hasegawa K, Suzuki M, Wurita A, Watanabe K, Suzuki O
    • Journal Title

      Forensic Toxicology

      Volume: 30(2) Pages: 156-161

    • NAID

      120005671502

    • Related Report
      2013 Final Research Report
  • [Journal Article] Analysis of ibotenic acid and muscimol in Amanitamushrooms by hydrophilic interaction liquid chromatography-tandem mass spectrometry.2012

    • Author(s)
      Kunio Gonmori, Koutaro Hasegawa, Hiroki Fujita, Yoshito Kamijo, Hideki Nozawa, Itaru Yamagishi, Kayoko Minakata, Kanako Watanabe, Osamu Suzuki
    • Journal Title

      Forensic Toxicology

      Volume: 30巻 Issue: 2 Pages: 168-172

    • DOI

      10.1007/s11419-012-0144-7

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] A new approach in tandem mass spectrometric simultaneous determination of perchlorate, thiocyanate, and iodide using their ternary complexes with tris (1,10-phenanthroline) iron(II) chelate2012

    • Author(s)
      Kayoko Minakata, Hideki Nozawa
    • Journal Title

      Forensic Toxicology

      Volume: 30巻 Issue: 2 Pages: 156-161

    • DOI

      10.1007/s11419-012-0140-y

    • NAID

      120005671502

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Mushroom toxins : a forensic toxicological review2011

    • Author(s)
      Gonmori K, Fujita H, Yokoyama K, Watanabe K, Suzuki O
    • Journal Title

      Forensic Toxicol

      Volume: 29 Pages: 85-94

    • Related Report
      2013 Final Research Report
  • [Journal Article] Determination of cyanide in blood by electrospray ionization tandem mass spectrometry after direct injection of dicyanogold2011

    • Author(s)
      Minakata K, Nozawa H, Gonmori K, Yamagishi I, Suzuki M, Hasegawa K, Watanabe K, Suzuki O
    • Journal Title

      Anal Bioanal Chem

      Volume: 400 Pages: 1945-1951

    • Related Report
      2013 Final Research Report
  • [Journal Article] Mushroom toxins: a forensic toxicological review2011

    • Author(s)
      Kunio Gonmori, Hiroki Fujita, Kazumasa Yokoyama, Kanako Watanabe, Osamu Suzuki
    • Journal Title

      Forensic Toxicology

      Volume: 29 Pages: 85-94

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] MALDI-Q-TOF mass spectrometric determination of alpha-amanitin, beta-amanitin, and phalloidin in urine2013

    • Author(s)
      Gonmori K, Minakata K, Suzuki M, Hasegawa K, Yamagishi I, Nozawa H, Wurita A, Watanabe K, Suzuki O
    • Organizer
      The 51th Annual Meeting of the International Association of Forensic Toxicologists 2013
    • Place of Presentation
      Funchal, Madeira, Portugal
    • Related Report
      2013 Final Research Report
  • [Presentation] Maldi-Q-Tof Mass Spectrometric Determination of alpha-amanitin, beta amanitin, and phalloidin in urine2013

    • Author(s)
      Gonmori K, Minakata K, Suzuki M, Hasegawa K, Yamagishi I, Nozawa H, Wurita A, Watanabe K, Suzuki O
    • Organizer
      The 51th Annual Meeting of The International Association of Forensic Toxicologists
    • Place of Presentation
      Funchal, Madeira, Portugal
    • Related Report
      2013 Annual Research Report
  • [Presentation] Determination of azide in gastric fluid and urine by flow-injection electrospray ionization tandem mass spectrometry2012

    • Author(s)
      Minakata K, Gonmori K, Nozawa H, Yamagishi I, Hasegawa K, Wurita A, Watanabe K, Suzuki O
    • Organizer
      The 50th Annual Meeting of the International Association of Forensic Toxicologists 2012
    • Place of Presentation
      Hamamatsu, Japan
    • Related Report
      2013 Final Research Report
  • [Presentation] A sensitive and fully automated method for GC-MS analysis of volatile organic compounds in whole blood using large volumes of headspace vapor2012

    • Author(s)
      Hasegawa K, Wurita A, Gonmori K, Nozawa H, Yamagishi I, Minakata K, Suzuki O, Watanabe K
    • Organizer
      The 50th Annual Meeting of the International Association of Forensic Toxicologists 2012
    • Place of Presentation
      Hamamatsu, Japan
    • Related Report
      2013 Final Research Report
  • [Presentation] Analysis of ibotenic acid and muscimol in Amanita mushrooms by hydrophilic interaction LC-MS-MS with solid-phase extraction2012

    • Author(s)
      Gonmori K, Hasegawa K, Fujita H, Kmijo Y, Nozawa H, Yamagishi I, Minakata K, Watanabe K, Suzuki O
    • Organizer
      The 50th Annual Meeting of the International Association of Forensic Toxicologists 2012
    • Place of Presentation
      Hamamatsu, Japan
    • Related Report
      2013 Final Research Report
  • [Presentation] Analysis of ibotenic acid and muscimol in Amanitta mushroom by hydrophilic interaction LC-MS-MS with solid phase extraction2012

    • Author(s)
      Kunio Gonmori, Koutaro Hasegawa, Hiroki Fujita, Yoshito Kamijo, Hideki Nozawa, Itaru Yamagishi, Kayoko Minakata, Kanako Watanabe, Osamu Suzuki
    • Organizer
      The 50th Annual Meeting of the International Association of Forensic Toxicologists
    • Place of Presentation
      Hamamatsu, Japan
    • Related Report
      2012 Research-status Report
  • [Presentation] A Sunsitive and fully automated method for GC-MS analysis of volatile organic cmpounds in whole blood using large volumes of headspace vapor2012

    • Author(s)
      Koutaro Hasegawa, Amin Wurita, Kunio Gonmori, Hideki Nozawa, Itaru Yamagishi, Kayoko Minakata, Kanako Watanabe, Osamu Suzuki
    • Organizer
      The 50th Annual Meeting of the International Association of Forensic Toxicologists
    • Place of Presentation
      Hamamatsu, Japan
    • Related Report
      2012 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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