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Inhibitory effect of drinking alcohol on restoration of spontaneous circulation by CPR in injured patients and its mechanism

Research Project

Project/Area Number 23590852
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Legal medicine
Research InstitutionKochi University

Principal Investigator

HASHIMOTO YOSHIAKI  高知大学, 教育研究部医療学系, 教授 (70135937)

Co-Investigator(Kenkyū-buntansha) FURUMIYA Jyunichi  高知大学, 教育研究部医療学系, 助教 (60363280)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Keywords心肺蘇生法 / 飲酒 / 心拍再開 / 法医解剖 / マグヌス法 / 飲酒傷病者 / 救急医学 / 救急病態病理学 / アルコール / トランスレーショナルリサーチ / 病態薬理学 / 病態病理学 / 薬理学
Research Abstract

To investigate whether drinking alcohol has inhibitory effects on the ability of arrested heart to exhibit restoration of spontaneous circulation by cardiopulmonary resuscitation (CPR), the medical records and forensic autopsy findings of patients who died after receiving CPR were examined retrospectively. Restoration of spontaneous circulation was not observed in the patients under the influence of drinking alcohol. Although the investigated numbers are small and further research is needed, our investigation suggests that ethanol may inhibit restoration of spontaneous circulation by CPR in patients with cardiac arrest. Such a tendency was observed in animal experiments of examining restoration of heat beats by reheating after the cessation of heat beats by cooling.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (12 results)

All 2013 2012 2011

All Presentation (12 results)

  • [Presentation] 心肺蘇生法のなされた院外心肺停止患者の飲酒率2013

    • Author(s)
      古宮淳一, 西村拡起, 中西祥徳, 橋本良明
    • Organizer
      第48回日本アルコール・薬物医学会
    • Place of Presentation
      岡山コンベンションセンター、岡山
    • Related Report
      2013 Final Research Report
  • [Presentation] 低酸素曝露心停止ラットの心肺蘇生における病態解析2013

    • Author(s)
      古宮淳一, 西村拡起, 中西祥徳, 橋本良明
    • Organizer
      第97次日本法医学会学術全国集会
    • Place of Presentation
      ロイトン札幌、札幌
    • Related Report
      2013 Final Research Report
  • [Presentation] 実験的心拍停止ラット心臓の心拍再開に及ぼすエタノールの影響2013

    • Author(s)
      西村拡起, 古宮淳一, 中西祥徳, 橋本良明
    • Organizer
      第97次日本法医学会学術全国集会
    • Place of Presentation
      ロイトン札幌、札幌
    • Related Report
      2013 Final Research Report
  • [Presentation] 実験的心拍停止ラット心臓の心拍再開に及ぼすエタノールの影響2013

    • Author(s)
      西村拡起、古宮淳一、中西祥徳、橋本良明
    • Organizer
      第97次日本法医学会学術全国集会
    • Place of Presentation
      札幌
    • Related Report
      2013 Annual Research Report
  • [Presentation] 低酸素曝露心停止ラットの心肺蘇生における病態解析2013

    • Author(s)
      古宮淳一、西村拡起、中西祥徳、橋本良明
    • Organizer
      第97次日本法医学会学術全国集会
    • Place of Presentation
      札幌
    • Related Report
      2013 Annual Research Report
  • [Presentation] 心肺蘇生法のなされた院外心肺停止患者の飲酒率2013

    • Author(s)
      古宮淳一、西村拡起、中西祥徳、橋本良明
    • Organizer
      第48回日本アルコール・薬物医学会
    • Place of Presentation
      岡山
    • Related Report
      2013 Annual Research Report
  • [Presentation] ラット心臓の収縮力および実験的心停止後の心拍再開能に及ぼすエタノールの影響2012

    • Author(s)
      古宮淳一, 西村拡起, 中西祥徳, 橋本良明
    • Organizer
      第96次日本法医学会学術全国集会
    • Place of Presentation
      アクトシティ浜松、浜松
    • Related Report
      2013 Final Research Report
  • [Presentation] ラット心臓の収縮力および実験的心停止後の心拍再開能に及ぼすエタノールの影響2012

    • Author(s)
      古宮淳一、西村拡起、中西祥徳、橋本良明
    • Organizer
      第96次日本法医学会学術全国集会
    • Place of Presentation
      アクトシティ浜松(静岡県)
    • Related Report
      2012 Research-status Report
  • [Presentation] ノルアドレナリンによるラット摘出心房収縮に及ぼすエタノールの影響2011

    • Author(s)
      古宮淳一, 西村拡起, 中西祥徳, 橋本良明
    • Organizer
      第46回日本アルコール・薬物医学会
    • Place of Presentation
      愛知県産業労働センター名古屋
    • Year and Date
      2011-10-13
    • Related Report
      2013 Final Research Report
  • [Presentation] Effect of alcohol on t he restoration of the heart beat by cardiopulmonary resuscitation in a d runken person with cardiac arrest af ter trauma2011

    • Author(s)
      Furumiya J, Nishimura H, Nakanishi A, Hashimoto Y
    • Organizer
      8^<th> International Symposiu m Advances in Legal Medicine
    • Place of Presentation
      Johann Wolfgang Goethe-University Campus Westend, Frankfurt, Germany
    • Year and Date
      2011-09-29
    • Related Report
      2013 Final Research Report
  • [Presentation] Effect of alcohol on the restoration of the heart beat by cardiopulmonary resuscitation in a drunken person with cardiac arrest after trauma2011

    • Author(s)
      Furumiya J, Nishimura H, Nakanishi A, Hashimoto Y
    • Organizer
      8th International Symposium Advances in Legal Medicine
    • Place of Presentation
      Johann Wolfgang Goethe-University, Campus Westend (Frankfurt, Germany)
    • Related Report
      2011 Research-status Report
  • [Presentation] ノルアドレナリンによるラット摘出心房収縮に及ぼすエタノールの影響2011

    • Author(s)
      古宮淳一、西村拡起、中西祥徳、橋本良明
    • Organizer
      第46回日本アルコール・薬物医学会
    • Place of Presentation
      愛知県産業労働センター (愛知県)
    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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