| Project/Area Number |
23590864
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Legal medicine
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| Research Institution | Kawasaki University of Medical Welfare |
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Principal Investigator |
MORIYA Fumio 川崎医療福祉大学, 医療福祉学部, 教授 (40182274)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2012: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
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| Keywords | 社会医学 / 法中毒学 / 静脈内投与薬物 / 塩基性薬物 / メタンフェタミン / 胃内分泌 / ガスクロマトグラフィー / ガスクロマトグラフ-質量分析法 / ガスクロマトブラフ‐質量分析法 / 薬物分析 / 静脈内投与 / 医療処置 / ガスクロマトグラフ-質量分析 |
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| Research Abstract |
I demonstrated that: (1) in both basic therapeutic agents that were intravenously administered during the course of unsuccessful medical treatments and intravenously self-administered methamphetamine, a relatively good positive correlation was observed between the levels of those substances in the blood and stomach contents; (2) the average stomach content-to-blood ratio was 9.59 for basic agents, 0.38 for acidic agents and 16.1 for methamphetamine; (3) up to 10 mg of methamphetamine can accumulate in the stomach; and (4) the stomach-to-blood methamphetamine ratio is significantly affected by the particular mechanism of death. The stomach content-to-blood ratio for basic drugs may serve as a criterion for discriminating whether a drug was administered orally or intravenously.
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