| Project/Area Number |
23590867
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General internal medicine (including Psychosomatic medicine)
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| Research Institution | Tohoku University |
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Principal Investigator |
TAKAYAMA Shin 東北大学, 医学(系)研究科(研究院), 准教授 (80579954)
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| Co-Investigator(Kenkyū-buntansha) |
IWASAKI Koh 国立病院機構西多賀病院, 漢方医学センター, センター長 (90396432)
SEKI Takashi 東北大学, 大学院医学系研究科, 講師 (90372292)
KIKUCHI Akiko 東北大学, 病院, 医員 (00400325)
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| Research Collaborator |
TOBITA Muneshige 国立病院機構, 米沢病院, 院長
ISHIDA Syuichi 石巻港湾病院, 院長
OIKAWA Takashi 国立病院機構, 八戸病院, 院長
AONUMA Takanori , 涌谷町・町民医療福祉センター, センター長
KATAYOSE Dai 宮城利府掖済会病院, 副院長
SHINKAWA Mitsutoshi 光が丘スペルマン病院, 医長
NUMATA Takehiro 東北大学, 病院, 医員
KANEKO Soichiro 東北大学, 病院, 技術補佐員
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| Project Period (FY) |
2011-04-28 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 漢方 / 東洋医学 / 脳血管障害後遺症 / 便秘 / 大建中湯 / 漢方薬 / 臨床研究 / 脳機能障害 / 腹部温熱刺激 / 脳血管障害 / 伝統医学 / 神経変性疾患 |
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| Outline of Final Research Achievements |
Poststroke patients with functional constipation were recruited in a study on the effects of the traditional Japanese medicine Daikenchuto (DKT). Thirty-four patients (mean age: 78 years) were randomly assigned to 2 groups; all patients received conventional therapy for constipation, and patients in the DKT group received 15g/day of DKT for 4 weeks. Constipation scoring system (CSS) points and the gas volume score (GVS) were recorded before and after a 4-week observation period. The total score on the CSS improved significantly in the DKT group compared to the control (p < 0.01). The GVS was also significantly reduced in the DKT group compared to the control (p = 0.03). DKT in addition to conventional therapy is effective in treating functional constipation in poststroke patients.
Abdominal thermal stimulation (40 ℃, 15 minutes) tended to increase the superior mesenteric artery blood flow in poststroke patients (mean age: 79 years) with functional constipation (p = 0.065).
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