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Effects of Daikenchuto and thermal therapy for the treatment of constipation in poststroke patients

Research Project

Project/Area Number 23590867
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field General internal medicine (including Psychosomatic medicine)
Research InstitutionTohoku University

Principal Investigator

TAKAYAMA Shin  東北大学, 医学(系)研究科(研究院), 准教授 (80579954)

Co-Investigator(Kenkyū-buntansha) IWASAKI Koh  国立病院機構西多賀病院, 漢方医学センター, センター長 (90396432)
SEKI Takashi  東北大学, 大学院医学系研究科, 講師 (90372292)
KIKUCHI Akiko  東北大学, 病院, 医員 (00400325)
Research Collaborator TOBITA Muneshige  国立病院機構, 米沢病院, 院長
ISHIDA Syuichi  石巻港湾病院, 院長
OIKAWA Takashi  国立病院機構, 八戸病院, 院長
AONUMA Takanori  , 涌谷町・町民医療福祉センター, センター長
KATAYOSE Dai  宮城利府掖済会病院, 副院長
SHINKAWA Mitsutoshi  光が丘スペルマン病院, 医長
NUMATA Takehiro  東北大学, 病院, 医員
KANEKO Soichiro  東北大学, 病院, 技術補佐員
Project Period (FY) 2011-04-28 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords漢方 / 東洋医学 / 脳血管障害後遺症 / 便秘 / 大建中湯 / 漢方薬 / 臨床研究 / 脳機能障害 / 腹部温熱刺激 / 脳血管障害 / 伝統医学 / 神経変性疾患
Outline of Final Research Achievements

Poststroke patients with functional constipation were recruited in a study on the effects of the traditional Japanese medicine Daikenchuto (DKT). Thirty-four patients (mean age: 78 years) were randomly assigned to 2 groups; all patients received conventional therapy for constipation, and patients in the DKT group received 15g/day of DKT for 4 weeks. Constipation scoring system (CSS) points and the gas volume score (GVS) were recorded before and after a 4-week observation period. The total score on the CSS improved significantly in the DKT group compared to the control (p < 0.01). The GVS was also significantly reduced in the DKT group compared to the control (p = 0.03). DKT in addition to conventional therapy is effective in treating functional constipation in poststroke patients.
Abdominal thermal stimulation (40 ℃, 15 minutes) tended to increase the superior mesenteric artery blood flow in poststroke patients (mean age: 79 years) with functional constipation (p = 0.065).

Report

(5 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (10 results)

All 2015 2014 Other

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 1 results,  Acknowledgement Compliant: 2 results) Presentation (6 results) (of which Invited: 2 results) Remarks (2 results)

  • [Journal Article] 脳血管障害後遺症患者の便秘症状に対する漢方薬大建中湯を用いた前向き比較試験2015

    • Author(s)
      沼田健裕, 高山真, 岩崎鋼, 石井正
    • Journal Title

      漢方と最新治療

      Volume: 印刷中

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Traditional Japanese medicine daikenchuto improves functional constipation in poststroke patients.2014

    • Author(s)
      Numata T, Takayama S, Tobita M, Ishida S, Katayose D, Shinkawa M, Oikawa T, Aonuma T, Kaneko S, Tanaka J, Kanemura S, Iwasaki K, Ishii T, Yaegashi N
    • Journal Title

      Evidence-based complementary and alternative medicine

      Volume: 2014 Issue: 1 Pages: 1-8

    • DOI

      10.1155/2014/231258

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] 東北大学における卒前、卒後漢方医学教育の現状2014

    • Author(s)
      高山真, 石井誠一, 高橋文恵, 沼田健裕, 武田卓, 石井正, 八重樫伸生
    • Organizer
      第46回日本医学教育学会
    • Place of Presentation
      和歌山県立医科大学(和歌山)
    • Year and Date
      2014-07-19
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 便秘症状のある脳血管障害患者に対する大建中湯内服効果の前向き研究2014

    • Author(s)
      沼田健裕, 高山真, 金子聡一郎, 岩崎 鋼, 石井 正, 及川隆司, 新川光俊, 片寄大, 八重樫伸生
    • Organizer
      第65回日本東洋医学会学術総会
    • Place of Presentation
      東京国際フォーラム(東京)
    • Year and Date
      2014-06-29
    • Related Report
      2014 Annual Research Report
  • [Presentation] 東北大学における鍼灸に関する教育・研究・診療の現状と東日本大震災に被災地で行った鍼灸マッサージ医療活動の報告2014

    • Author(s)
      高山真
    • Organizer
      第65回日本東洋医学会学術総会
    • Place of Presentation
      東京国際フォーラム(東京)
    • Year and Date
      2014-06-29
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] The effects of acupuncture and abdominal thermal stimulation on blood flow in humans2014

    • Author(s)
      Takayama Shin
    • Organizer
      39th World Congress of International Society of Medical Hydrology and Climatology
    • Place of Presentation
      国立京都国際会館(京都)
    • Year and Date
      2014-05-11
    • Related Report
      2014 Annual Research Report
  • [Presentation] 脳血管障害後の便秘症状に対する大建中湯の効果2014

    • Author(s)
      沼田健裕, 高山真, 岩崎鋼, 石井正
    • Organizer
      第111回日本内科学会総会
    • Place of Presentation
      東京国際フォーラム(東京)
    • Year and Date
      2014-04-11
    • Related Report
      2014 Annual Research Report
  • [Presentation] 便秘症状のある脳血管障害患者に対する大建中湯内服効果の前向き研究2014

    • Author(s)
      沼田 健裕、高山 真、金子 聡一郎、岩崎 鋼、石井 正、八重樫 伸生
    • Organizer
      第65回日本東洋医学会学術総会
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
  • [Remarks] 脳血管障害後遺症患者の便秘症に漢方薬が有効-便秘治療に新たな可能性-

    • URL

      http://www.hosp.tohoku.ac.jp/release/news/2959.html

    • Related Report
      2014 Annual Research Report
  • [Remarks] 東北大学病院 漢方内科 フェイスブック 最近の論文報告(8)

    • URL

      https://www.facebook.com/kampo.tohoku.med

    • Related Report
      2014 Annual Research Report

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Published: 2011-08-05   Modified: 2019-07-29  

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