| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Research Abstract |
To develop a possibly new medical treatment for anorexia nervosa, we aimed to investigate the effects of ghrelin on gastric function by using electrogastrography (EGG) as a non-invasive technique. Because Rikkunshito (TJ-43), a traditional Japanese medicine, stimulates ghrelin secretion, we studied the effects of TJ-43 on the gastric electrical activity of patients with anorexia nervosa. The % normal power and % arrhythmia of EGG in patients with anorexia nervosa were significantly lower and higher than those of healthy controls, respectively. Oral administration with 5g TJ-43 resolved in 50ml water significantly decreased % arrhythmia of EGG in patients with anorexia nervosa compared to the 50ml water load. TJ-43 may improve gastric myoelectrical rhythms in patients with anorexia nervosa, suggesting that the effect of ghrelin on appetite would be related to amelioration of gastric myoelectric activity.
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