Phenotypic alterations of brain microvascular endothelium in a model of Alzheimer disease
| Project/Area Number |
23590874
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General internal medicine (including Psychosomatic medicine)
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| Research Institution | National Cardiovascular Center Research Institute |
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Principal Investigator |
HAYASHI Shinichiro 独立行政法人国立循環器病研究センター, 病院, 医師 (20396740)
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| Co-Investigator(Kenkyū-buntansha) |
SATO Naoyuki 大阪大学, 医学系研究科, 寄付講座准教授 (70372612)
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| Co-Investigator(Renkei-kenkyūsha) |
YAMAMOTO Akitsugu 長浜バイオ大学, バイオサイエンス研究科, 教授 (30174775)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | アルツハイマー病 / オートファジー / 血管内皮 |
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| Research Abstract |
The cause and progression of Alzheimer disease (AD) still remains unclear. Our present findings indicate that the progression of AD might be in part driven by phenotypic alterations in neurovascular endothelium with induction of endothelial autophagy and impairment of neurovascular regeneration in diseased brain.
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Report
(4 results)
Research Products
(45 results)
