Interaction of cognitive function and glucose metabolism -angiotenisn IV and IRAP system as a new therapeutic target-
| Project/Area Number |
23590877
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General internal medicine (including Psychosomatic medicine)
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| Research Institution | Kagoshima University (2012-2013)
Osaka University (2011) |
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Principal Investigator |
OHISHI Mitsuru 鹿児島大学, 医歯(薬)学総合研究科, 教授 (50335345)
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| Co-Investigator(Kenkyū-buntansha) |
YAMAMOTO Koichi 大阪大学, 老年・腎臓内科学, 講師 (00528424)
楽木 宏実 (樂木 宏実) 大阪大学, 老年・腎臓内科学, 教授 (20252679)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | アンジオテンシン IV / アンジオテンシン 1-7 / 認知機能 / 耐糖能異常 / IRAP / angiotensin IV / angiotensin 1-7 / ACE2 / AngIV / 実験動物 / 組織学的検査 |
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| Research Abstract |
The Australian laboratory which I investigated before cloned the insulin-regulated aminopeptidase (IRAP) as a receptor for angiotensin IV, sub-component of renin-angiotensin system. It is a member of the family of zinc- dependent membrane aminopeptidases, which is mainly located in hippocampus and plays an important role for translocation to membrane of GLUT4. We reported another sub-component, angiotensin (1-7) improved glucose intolerance via increased MEF1 and GLUT4 production. We planned angiotensin IV and IRAP as a new therapeutic target for cognitive impairment using amyloid beta 1-40 intra-ventricular infusion model with IRAP knockout mice donated from the Australian laboratory. The cognitive function of this model is too unstable to evaluate angiotensin IV and IRAP function for cognitive impairment, we are now planning to make double knockout mice with IRAP and APP.
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Report
(4 results)
Research Products
(17 results)
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[Journal Article] Tissue inhibitor of metalloproteinase-3 knockout mice exhibit enhanced energy expenditure through thermogenesis2014
Author(s)
Hanaoka Y, Yasuda O, Soejima H, Miyata K, Yamamoto E, Izumiya Y, Maeda N, Ohishi M, Rakugi H, Oike Y, Kim-Mitsuyama S, Ogawa H
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] Loss of Angiotensin-converting enzyme 2 exaggerates high-calorie diet-induced insulin resistance by reduction of GLUT4 in mice2013
Author(s)
Takeda M, Yamamoto K, Takemura Y, Takeshita H, Hongyo K, Kawai T, Hanasaki-Yamamoto H, Oguro R, Takami Y, Tatara Y, Takeya Y, Sugimoto K, Kamide K, Ohishi M, Rakugi H
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Journal Title
Diabetes
Volume: 62(1)
Pages: 223-233
Related Report
Peer Reviewed
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[Journal Article] Loss of Angiotensin-converting enzyme 2 exaggerates high-calorie diet-induced insulin resistance by reduction of GLUT4 in mice2013
Author(s)
4. Takeda M, Yamamoto K, Takemura Y, Takeshita H, Hongyo K, Kawai T, Hanasaki-Yamamoto H, Oguro R, Takami Y, Tatara Y, Takeya Y, Sugimoto K, Kamide K, Ohishi M, Rakugi H.
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Journal Title
Diabetes
Volume: 62
Pages: 223-233
Related Report
Peer Reviewed
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[Journal Article] Genetic Variants at the 9q21 locus contribute to atherosclerosis through modulation of ANRIL and CDKN2A/B2012
Author(s)
Congrains CA, Kamide K, Oguro R, Yasuda O, Miyata K, Yamamoto E, Kawai T, Kusunoki H, Yamamoto H, Takeya Y, Yamamoto K, Onishi M, Sugimoto K, Katsuya T, Awata N, Ikebe K, Gondo Y, Oike Y, Ohishi M, Rakugi H
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Journal Title
Atherosclerosis
Volume: 220
Pages: 449-455
Related Report
Peer Reviewed
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