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Cross link between diabetes mellitus and bone metabolism in the aspect of renin angiotensin system

Research Project

Project/Area Number 23590879
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field General internal medicine (including Psychosomatic medicine)
Research InstitutionOsaka University

Principal Investigator

SHIMIZU Hideo  大阪大学, 医学(系)研究科(研究院), 特任准教授 (50388378)

Co-Investigator(Kenkyū-buntansha) RAKUGI Hiromi  大阪大学, 大学院医学系研究科・老年腎臓内科, 教授 (20252679)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords骨代謝 / 糖尿病 / レニン / アンジオテンシン / 降圧薬
Research Abstract

10 weeks-old rats were ovariectomised and fed with high-fructose diet for 1M to develop type 2 diabetes mellitus. These animals demonstrated high turnover in bone metabolisms, glucose- and insulin- tolerance accompanying activation of renin angiotensin system. They also revealed accumulation of advanced glycation-endo products with fragility of bone assessed by 3-ponit vending test. Angiotensin type 1 receptor blockers ameliorated these parameters with its beneficial pleiotropic effects.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (15 results)

All 2014 2013 2012 2011 Other

All Journal Article (3 results) (of which Peer Reviewed: 1 results) Presentation (10 results) Remarks (2 results)

  • [Journal Article] Olmesartan Reduces Pentosidine Production and Ameliorates Fragility of Bone in Ovariectomized Fructose-Fed Rats2013

    • Author(s)
      Shimizu H, Nakagami H, Yasumasa N, Osako MK, Morishita R
    • Journal Title

      Immun Endoc and Metab Agents in Med Chem

      Volume: 13(2) Pages: 150-158

    • Related Report
      2013 Final Research Report
  • [Journal Article] Olmesartan Reduces Pentosidine Production and Ameliorates Fragility of Bone in Ovariectomized Fructose-Fed Rats2013

    • Author(s)
      Shimizu H, Nakagami H, Yasumasa N, Mariana OK, Morishita R
    • Journal Title

      Immun., Endoc. & Metab. Agents in Med. Chem

      Volume: 13 Issue: 2 Pages: 150-158

    • DOI

      10.2174/1871522211313020010

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Screening of Antihypertensive Drugs for Osteoclastic Acid Secretion and Bone Resorption by Acridine Orange2012

    • Author(s)
      Shimizu H, Nakagami H, Yasumasa N, Osako MK, Kyutoku M, Koriyama H, Nakagami F, Shimamura M, Rakugi H, Morishita R
    • Journal Title

      Immun Endoc and Metab Agents in Med Chem

      Volume: 12(3) Issue: 3 Pages: 161-167

    • DOI

      10.2174/187152212802001857

    • Related Report
      2013 Final Research Report
  • [Presentation] 血管石灰化と骨代謝の共通分子基盤としてのレニンアンジオテンシン系2014

    • Author(s)
      志水秀郎、中神啓徳、森下竜一
    • Organizer
      第19回アンジオテンシンカンファレンス
    • Place of Presentation
      豊中市千里ライフサイエンスセンター
    • Year and Date
      2014-02-01
    • Related Report
      2013 Final Research Report
  • [Presentation] 血管石灰化と骨代謝の共通分子基盤としてのレニンアンジオテンシン系2014

    • Author(s)
      志水秀郎、中神啓徳、森下竜一
    • Organizer
      第19回アンジオテンシンカンファレンス
    • Place of Presentation
      大阪府豊中市 千里ライフサイエンスセンター
    • Related Report
      2013 Annual Research Report
  • [Presentation] 糖代謝におけるレニン・アンジオテンシン系の役割2013

    • Author(s)
      志水秀郎、中神啓徳、森下竜一
    • Organizer
      脳心血管抗加齢研究会2013
    • Place of Presentation
      大阪市梅田スカイビル
    • Year and Date
      2013-12-14
    • Related Report
      2013 Final Research Report
  • [Presentation] アクリジン・オレンジを用いた破骨細胞酸産生能評価による各種降圧剤のスクリーニング2013

    • Author(s)
      志水秀郎、中神啓徳、尾崎和成、楠博、森下竜一
    • Organizer
      第13回抗加齢医学会総会
    • Place of Presentation
      横浜市
    • Year and Date
      2013-06-28
    • Related Report
      2013 Final Research Report
  • [Presentation] 糖代謝におけるレニン・アンジオテンシン系の役割2013

    • Author(s)
      志水秀郎、中神啓徳、森下竜一
    • Organizer
      脳心血管抗加齢研究会2013
    • Place of Presentation
      大阪市北区 梅田スカイビル
    • Related Report
      2013 Annual Research Report
  • [Presentation] アクリジン・オレンジを用いた破骨細胞酸産生能評価による各種降圧剤のスクリーニング2013

    • Author(s)
      志水秀郎、中神啓徳、尾崎和成、楠博、森下竜一
    • Organizer
      第13回日本抗加齢医学会総会
    • Place of Presentation
      横浜市 パシフィコ横浜
    • Related Report
      2013 Annual Research Report
  • [Presentation] 降圧薬の多面的効果、骨代謝改善作用について2012

    • Author(s)
      志水秀郎、中神啓徳、楽木宏実、森下隆一
    • Organizer
      アンチエイジングフェスタ2012
    • Place of Presentation
      大阪市
    • Year and Date
      2012-11-17
    • Related Report
      2013 Final Research Report
  • [Presentation] 降圧薬の多面的効果、骨代謝改善作用について2012

    • Author(s)
      志水秀郎、中神啓徳、楽木宏実、森下隆一
    • Organizer
      アンチエイジングフェスタ(脳心血管加齢研究会)
    • Place of Presentation
      大阪(ハービスホール)
    • Related Report
      2012 Research-status Report
  • [Presentation] 低用量の利尿剤とARB併用によるRAS活性の抑制と骨代謝改善効果2011

    • Author(s)
      志水秀郎、中神啓徳、森下竜一
    • Organizer
      第11回日本抗加齢医学会総会
    • Place of Presentation
      京都国際会館
    • Related Report
      2011 Research-status Report
  • [Presentation] 骨代謝に対するアンジオテンシン受容体拮抗薬の効果2011

    • Author(s)
      志水秀郎、中神啓徳、大石充、楽木宏実、森下竜一
    • Organizer
      第22回日本老年病学会近畿地方会
    • Place of Presentation
      兵庫医科大学
    • Related Report
      2011 Research-status Report
  • [Remarks]

    • URL

      http://www.cgt.med.osaka-u.ac.jp/vme/research_06.html

    • Related Report
      2013 Final Research Report
  • [Remarks]

    • URL

      http://www.cgt.med.osaka-u.ac.jp/vme/research_03.html

    • Related Report
      2013 Final Research Report

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Published: 2011-08-05   Modified: 2019-07-29  

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