• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Mild parkinsonian sings converting to dementia and/or parkinsonism

Research Project

Project/Area Number 23590881
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field General internal medicine (including Psychosomatic medicine)
Research InstitutionTottori University

Principal Investigator

NAKASHIMA Kenji  鳥取大学, 医学部, 教授 (70144673)

Co-Investigator(Renkei-kenkyūsha) WADA Kenji  鳥取大学, 医学部付属病院, 講師 (60346351)
NAKASHITA Satoko  鳥取大学, 医学部付属病院, 助教 (00569270)
TANAKA Kenichiro  鳥取大学, 医学部付属病院, 医員 (60625846)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords老年医学 / 臨床神経学 / 地域疫学 / 軽度パーキンソン徴候 / 認知症 / 高齢者 / パーキンソン症候群 / パーキンソン病 / 軽度認知障害 / うつ / 運動機能
Research Abstract

Mild parkinsonian signs (MPS) are reported to be associated with increased risks of dementia, Parkinson's disease, parkinsonism and vascular lesions of white matter. MPS subjects were converted more frequently to parkinsonism and/or dementia and showed higher mortality rate, when compared with control subjects. MPS should be paid more attention.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (41 results)

All 2013 2012 2011

All Journal Article (18 results) (of which Peer Reviewed: 15 results) Presentation (21 results) Book (2 results)

  • [Journal Article] Depression and cognitive impairment in patients with mild parkinsonian signs2013

    • Author(s)
      Uemura Y, Wada-Isoe K, Nakashita S, Nakashima K
    • Journal Title

      Acta Neurologica Scandinavica

      Volume: 128 Pages: 153-159

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Impulsive compulsive behaviors in Japanese Parkinson's disease patients and utility of the Japanese version of the Questionnaire for Impulsive-Compulsive Disorders in Parkinson's disease2013

    • Author(s)
      Tanaka K, Wada-Isoe K, Nakashita N, Yamamoto M, Nakashima K
    • Journal Title

      Journal of the Neurological Sciences

      Volume: 331 Pages: 76-80

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Depression and cognitive impairment in patients with mild parkinsonian signs.2013

    • Author(s)
      Uemura Y, Wada-Isoe K, Nakashita S, Nakashima K.
    • Journal Title

      Acta Neurologica Scandinavica

      Volume: 128 Issue: 3 Pages: 153-159

    • DOI

      10.1111/ane.12089

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Impulsive compulsive behaviors in Japanese Parkinson's disease patients and utility of the Japanese version of the Questionnaire for Impulsive–Compulsive Disorders in Parkinson's disease2013

    • Author(s)
      Tanaka K, Wada-Isoe K, Nakashita N, Yamamoto M, Nakashima K.
    • Journal Title

      Journal of the Neurological Sciences

      Volume: 331 Issue: 1-2 Pages: 76-80

    • DOI

      10.1016/j.jns.2011.02.013

    • Related Report
      2013 Annual Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Characteristics of obstructive sleep apnea in patients with Parkinson's disease2013

    • Author(s)
      Nomura T, Inoue Y, Kobayashi M, Namba K, Nakashima K
    • Journal Title

      Jounal of Neurological Sciences

      Volume: 327 Pages: 22-24

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Dopamine-mediated oxidation of methionine 127 in α-synuclein causes cytotoxicity and oligomerization of α-synuclein.2013

    • Author(s)
      Nakaso K, Tajima N, Ito S, Teraoka M, Yamashita A, Horikoshi Y, Kikuchi D, Mochida S, Nakashima K and Matsura T
    • Journal Title

      PLOS ONE

      Volume: 8 Issue: 2 Pages: 1-9

    • DOI

      10.1371/journal.pone.0055068

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Clinical significance of REM sleep behavior disorder in Parkinson's disease2013

    • Author(s)
      Nomura T, Inoue Y, Kagimura T, Nakashima K
    • Journal Title

      Sleep Medicine

      Volume: 14 Pages: 131-135

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Comparison of REM sleep behaviour disorder variables between patients with progressive supranuclear palsy and those with Parkinson’s disease2012

    • Author(s)
      Nomura T, Inoue Y, Takigawa H, Nakashima K
    • Journal Title

      Parkinsonism and Related Disorders

      Volume: 18 Pages: 394-396

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Multicentre population-based dementia prevalence survey in Japan:a preliminary report2012

    • Author(s)
      Ikejima C, Hisanaga A, Meguro K, Yamada T, Ouma S, Kawamuro Y, Hyouki K, Nakashima K, Wada K,Ymada S, Watanabe I, Kakuma T, Aoyama Y, Mizukami K, Asada T
    • Journal Title

      Psychogeriatrics

      Volume: 12 Issue: 2 Pages: 120-123

    • DOI

      10.1111/j.1479-8301.2012.00415.x

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Epidemiological Survey of Frontotemporal Lobar Degeneration in Tottori Prefecture, Japan2012

    • Author(s)
      Wada-Isoe K, Ito S, Adachi T, Yamawaki M, Nakashita S, Kusumi M, Hiroe Y, Takada T, Watanabe K, Hikasa C, Nakashima K
    • Journal Title

      Dementia Geriatric Cognitive Disorders Extra

      Volume: 2 Issue: 1 Pages: 381-386

    • DOI

      10.1159/000342972

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Leber’s Hereditary Optic Neuropathy with Olivocerebellar Degeneration due to G11778A and T3394C Mutations in the Mitochondrial DNA2012

    • Author(s)
      Nakaso K, Adachi Y, Fusayasu E, Doi K, Imamura K, Yasui K, Nakashima K
    • Journal Title

      Journal of Clinical Neurology

      Volume: 8 Issue: 3 Pages: 230-234

    • DOI

      10.3988/jcn.2012.8.3.230

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Heparin-induced thrombocytopenia in essential thrombocytosis2012

    • Author(s)
      Murawaki A, Nakayasu H, Doi M, Suzuki-Kinoshita K, Asai Y, Omura H, Nakashima K
    • Journal Title

      Journal of Stroke Cerebrovascular Diseases

      Volume: 21

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Prevalence of dementia and mild cognitive impairment in the rural island town of Ama-cho, Japan2012

    • Author(s)
      Wada-Isoe K, Uemura Y, Nakashita S, Yamawaki M, Tanaka K, Yamamoto M, Shimokata H, Nakashima K
    • Journal Title

      Dementia Geriatric Cognitive Disorders Extra

      Volume: 2巻 Issue: 1 Pages: 190-199

    • DOI

      10.1159/000338244

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] 認知症ガイドライン2010のポイント2012

    • Author(s)
      中島健二、和田健二
    • Journal Title

      内科

      Volume: 109巻 Pages: 763-767

    • Related Report
      2011 Research-status Report
  • [Journal Article] Utility of the REM sleep behavior disorder screening questionnaire (RBDSQ) in Parkinson’s disease patients2011

    • Author(s)
      Nomura T, Inoue Y, Kagimura T, Uemura Y, Nakashima K
    • Journal Title

      Sleep Medicine

      Volume: 12巻 Issue: 7 Pages: 711-713

    • DOI

      10.1016/j.sleep.2011.01.015

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] 大山町研究と海士町研究2011

    • Author(s)
      和田健二、山脇美香、中島健二
    • Journal Title

      日本臨牀

      Volume: 69巻 Pages: 61-620

    • Related Report
      2011 Research-status Report
  • [Journal Article] 認知症のガイドラインをめぐって2011

    • Author(s)
      中島健二、和田健二
    • Journal Title

      神経内科

      Volume: 75巻 Pages: 24-32

    • Related Report
      2011 Research-status Report
  • [Journal Article] 多発性の大脳微小出血を認めたパーキンソニズム2011

    • Author(s)
      中下聡子、和田健二、足立芳樹、渡辺保裕、中島健二
    • Journal Title

      神経内科

      Volume: 74巻 Pages: 324-326

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] Mild parkisonian signs in a community-dwelling elderly population : a prospective mortality study2013

    • Author(s)
      Tanaka K, Wada-Isoe K, Nakashita S, Yamamoto M, Tagashira S, Tajiri Y, Nakashima K
    • Organizer
      第54回日本神経学会学術集会
    • Place of Presentation
      東京国際フォーラム(東京)
    • Related Report
      2013 Final Research Report
  • [Presentation] 地域住民における主観的認知障害と脳灰白質萎縮の検討2013

    • Author(s)
      山本幹枝,和田健二,田中健一郎,中下聡子,山脇美香,山下典生,中島健二
    • Organizer
      第54回日本神経学会学術集会
    • Place of Presentation
      東京国際フォーラム(東京)
    • Related Report
      2013 Final Research Report
  • [Presentation] 地域住民におけるamnesticMCIと脳灰白質萎縮関連因子の検討2013

    • Author(s)
      山本幹枝,和田健二,田中健一郎,中下聡子,山脇美香,山下典生,川口淳,中島健二
    • Organizer
      第32回日本認知症学会学術集会
    • Place of Presentation
      松本市総合体育館(松本)
    • Related Report
      2013 Final Research Report
  • [Presentation] 地域高齢住民における認知機能,運動機能,精神機能の縦断的検討2013

    • Author(s)
      田中健一郎,和田健二,植村佑介,中下聡子,山本幹枝,田頭秀悟,田尻佑喜,中島健二
    • Organizer
      第32回日本認知症学会学術集会
    • Place of Presentation
      松本市総合体育館(松本)
    • Related Report
      2013 Final Research Report
  • [Presentation] Mild parkisonian signs in a community-dwelling elderly population: a prospective mortality study2013

    • Author(s)
      Tanaka K, Wada-Isoe K, Nakashita S, Yamamoto M, Tagashira S, Tajiri Y, Nakashima K.
    • Organizer
      第54回 日本神経学会学術集会
    • Place of Presentation
      東京国際フォーラム(東京)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 地域住民における主観的認知障害と脳灰白質萎縮の検討2013

    • Author(s)
      山本幹枝,和田健二,田中健一郎 ,中下聡子,山脇美香,山下典生,中島健二
    • Organizer
      第54回 日本神経学会学術集会
    • Place of Presentation
      東京国際フォーラム(東京)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 地域住民におけるamnestic MCI と脳灰白質萎縮関連因子の検討2013

    • Author(s)
      山本幹枝,和田健二,田中健一郎,中下聡子,山脇美香,山下典生,川口淳,中島健二
    • Organizer
      第32回日本認知症学会学術集会
    • Place of Presentation
      松本市総合体育館(松本)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 地域高齢住民における認知機能,運動機能,精神機能の縦断的検討2013

    • Author(s)
      田中健一郎,和田健二,植村佑介,中下聡子,山本幹枝,田頭秀悟,田尻佑喜,中島健二
    • Organizer
      第32回日本認知症学会学術集会
    • Place of Presentation
      松本市総合体育館(松本)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 地域疫学調査による大脳白質病変と運動機能、認知機能および精神機能の検討2012

    • Author(s)
      山脇美香、山本幹枝、中下聡子、植村佑介、和田健二、中島健二
    • Organizer
      第53回日本神経学会学術大会
    • Place of Presentation
      東京国際フォーラム(東京)
    • Related Report
      2012 Research-status Report
  • [Presentation] レビー小体型認知症の血清バイオマーカーの検討2012

    • Author(s)
      中下聡子、和田健二、中島健二
    • Organizer
      第53回日本神経学会学術大会
    • Place of Presentation
      東京国際フォーラム(東京)
    • Related Report
      2012 Research-status Report
  • [Presentation] パーキンソン病における衝動制御障害のスクリーニングアンケートの有用性の検討2012

    • Author(s)
      田中健一郎、和田健二、中下聡子、山本幹枝、中島健二
    • Organizer
      第53回日本神経学会学術大会
    • Place of Presentation
      東京国際フォーラム(東京)
    • Related Report
      2012 Research-status Report
  • [Presentation] パーキンソン病における嗅覚障害とレム睡眠行動異常症の関連2012

    • Author(s)
      野村哲志、井上雄一、中島健二
    • Organizer
      第6回パーキンソン病・運動障害疾患コングレス(MDSJ)
    • Place of Presentation
      京都ホテルオークラ(京都)
    • Related Report
      2012 Research-status Report
  • [Presentation] 地域疫学調査における認知症スクリーニング検査の検討2012

    • Author(s)
      和田健二、植村佑介、中下聡子、田中健一郎、山本幹枝、田頭秀悟、中島健二
    • Organizer
      第31回日本認知症学会学術集会
    • Place of Presentation
      つくば国際会議場(筑波)
    • Related Report
      2012 Research-status Report
  • [Presentation] Difference in RBD manifestation between tauopathy and alpha-synucleinopathy2011

    • Author(s)
      Nomura T, Inoue Y, Nakashima K
    • Organizer
      The 5th International REM Sleep Behavior Disorder Symposium
    • Place of Presentation
      琵琶湖ホテル(大津)
    • Related Report
      2011 Research-status Report
  • [Presentation] Prevalence of dementia and mild cognitive impairment in the rural island town of Ama-cho, Japan2011

    • Author(s)
      Wada-Isoe, Uemura Y, Nakashita S, Yamawaki M, Tanaka K, Nakashima K
    • Organizer
      15the EFNS Congress
    • Place of Presentation
      Hungexpo(Budapest)
    • Related Report
      2011 Research-status Report
  • [Presentation] 神経内科治療ガイドライン:認知症2011

    • Author(s)
      中島健二
    • Organizer
      第52回日本神経学会学術大会(招待講演)
    • Place of Presentation
      名古屋国際会議場(名古屋)
    • Related Report
      2011 Research-status Report
  • [Presentation] 地域疫学調査による大脳白質病変の検討2011

    • Author(s)
      山脇美香、中下聡子、植村佑介、和田健二、中島健二
    • Organizer
      第52回日本神経学会学術大会
    • Place of Presentation
      名古屋国際会議場(名古屋)
    • Related Report
      2011 Research-status Report
  • [Presentation] ALSモデルマウス脊髄不溶性分画の2次元電気泳動プロテオミクス解析2011

    • Author(s)
      渡辺保裕、河瀬真也、安井建一、北山通朗、中野俊也、中島健二
    • Organizer
      第52回日本神経学会学術大会
    • Place of Presentation
      名古屋国際会議場(名古屋)
    • Related Report
      2011 Research-status Report
  • [Presentation] 地域におけるパーキンソニズムの原因疾患についての検討2011

    • Author(s)
      中下聡子、和田健二、植村佑介、山脇美香、中島健二
    • Organizer
      第52回日本神経学会学術大会
    • Place of Presentation
      名古屋国際会議場(名古屋)
    • Related Report
      2011 Research-status Report
  • [Presentation] 鳥取県米子市における進行性核上性麻痺(PSP)の疫学的検討 第2報2011

    • Author(s)
      瀧川洋史、北山通朗、和田健二、古和久典、中島健二
    • Organizer
      第52回日本神経学会学術大会
    • Place of Presentation
      名古屋国際会議場(名古屋)
    • Related Report
      2011 Research-status Report
  • [Presentation] パーキンソン病とコリン作動性障害-認知障害-2011

    • Author(s)
      中島健二
    • Organizer
      第5回パーキンソン病・運動障害疾患コングレス(招待講演)
    • Place of Presentation
      品川プリンスホテル(東京)
    • Related Report
      2011 Research-status Report
  • [Book] 認知症診療Q&A 922012

    • Author(s)
      中島健二、和田健二 編
    • Total Pages
      309
    • Publisher
      中外医学社
    • Related Report
      2012 Research-status Report
  • [Book] "認知症疾患治療ガイドライン2010"コンパクト版20122012

    • Author(s)
      "認知症疾患治療ガイドライン"作成合同委員会
    • Total Pages
      234
    • Publisher
      医学書院
    • Related Report
      2011 Research-status Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi