• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Development of novel combined cancer immunotherapy using adoptive naive T cell transfer.

Research Project

Project/Area Number 23590891
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field General internal medicine (including Psychosomatic medicine)
Research InstitutionKyoto Prefectural University of Medicine

Principal Investigator

ISHIKAWA Takeshi  京都府立医科大学, 医学(系)研究科(研究院), 講師 (90372846)

Co-Investigator(Kenkyū-buntansha) KOKURA Satoshi  (財)ルイ・パストゥール医学研究センター, 研究員 (80347442)
ADACHI Satoko  京都府立医科大学, 医学部, 研究員 (90546615)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywordsがん免疫療法 / ナイーブTリンパ球 / CTLA-4 / 細胞療法 / 細胞移入療法 / ナイーブTリンパ球 / CTLA4阻害 / NK細胞療法
Research Abstract

In adoptive cell therapy(ACT), the intrinsic properties of the transferred cell population, particularly its state of differentiation, are considered to be crucial to the success of ACT based approaches, and naive T cells are ideal for ACT because of their in vivo persistence and high proliferative potential.In this study, we evaluated the synergic anti-tumor effect of CTLA-4 blockade combined with ACT considering the state of differentiation of transferred cells in mouse colon cancer model.CTLA-4 blockade combined with naive T-cell transfer showed the strongest antitumor effect among all groups. Moreover, CTLA-4 blockade can drive polarization of tumor-infiltrating T cells toward the T helper 1 lineage and suppress the frequency of Tregs within tumor especially in combination with naive T-cell transfer.These data support the notion that the combination of CTLA-4 blockade and ACT containing a lot of naive cells could expert powerful antitumor effects in clinical setting.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (24 results)

All 2014 2013 2011 Other

All Journal Article (8 results) (of which Peer Reviewed: 6 results,  Open Access: 1 results) Presentation (16 results)

  • [Journal Article] Phase I clinical trial of fibronectin CH296-stimulated T cell therapy in patients2014

    • Author(s)
      Ishikawa T, Kokura S, Enoki T, et al.
    • Journal Title

      PLoS One

      Volume: 9(1) Issue: 1 Pages: 1-9

    • DOI

      10.1371/journal.pone.0083786

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The inhibitory effect of heat treatment against Epithelial-Mesenchymal Transition (EMT) in human pancreatic adenocarcinoma cell lines2014

    • Author(s)
      Kimura R, Ishikawa T, Kokura S, et al
    • Journal Title

      J Clin Biochem Nutr

      Volume: -

    • NAID

      130004466768

    • Related Report
      2013 Annual Research Report
  • [Journal Article] Whole blood interferon-γ levels predict the therapeutic effects of adoptive T-cell therapy in patients with advanced pancreatic cancer2013

    • Author(s)
      Ishiakwa T, Kokura S, Sakamoto N, et al
    • Journal Title

      Int J Cancer

      Volume: 未定 Issue: 5 Pages: 1119-25

    • DOI

      10.1002/ijc.28117

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Anoxia/reoxygenation induces epithelial-mesenchymal transition in human colon cancer cell lines2013

    • Author(s)
      Okajima M, Kokura S, Ishikawa T, et al
    • Journal Title

      Oncol Rep

      Volume: 29(6) Issue: 6 Pages: 2311-2317

    • DOI

      10.3892/or.2013.2401

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effects of anticancer agents on cell viability, proliferative activity and cytokine production of peripheral blood mononuclear cells2013

    • Author(s)
      Sakai H, Kokura S, Ishikawa T, et al
    • Journal Title

      Journal of Clinical Biochemistry and Nutrition

      Volume: 52 Issue: 1 Pages: 64-71

    • DOI

      10.3164/jcbn.12-60

    • NAID

      130004879315

    • ISSN
      0912-0009, 1880-5086
    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Adoptive cellular therapy enhances the helper T cell response and reduces the number of regulatory T cells2011

    • Author(s)
      Ishikawa T, Kokura S, Sakamoto N, et al
    • Journal Title

      Exp Ther Med

      Volume: 2(4)(Epub) Pages: 737-743

    • Related Report
      2013 Final Research Report
  • [Journal Article] Adoptive cellular therapy enhances the helper T cell response and reduces the number of regulatory T cells2011

    • Author(s)
      Ishikawa T, Kokura S, et al
    • Journal Title

      EXPERIMENTAL AND THERAPEUTIC MEDICINE

      Volume: 2 Pages: 737-743

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Decrease of the regulatory T-cell population by adoptive T-cell transfer in a mouse colorectal cancer transplant model.2011

    • Author(s)
      Ishikawa T, Kokura S, et al
    • Journal Title

      Oncol Res.

      Volume: 19 Pages: 543-554

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] 未分化型Tリンパ球移入療法の抗腫瘍効果に対する抗CTLA-4抗体の増強効果について2013

    • Author(s)
      石川剛、足立聡子、岡山哲也、他
    • Organizer
      第26回日本バイオセラピィ学会学術集会
    • Place of Presentation
      盛岡
    • Year and Date
      2013-12-05
    • Related Report
      2013 Final Research Report
  • [Presentation] 疫細胞移入療法における低分化型リンパ球移入の意義-レトロネクチン誘導Tリンパ球療法の第I相臨床試験における解析結果からの検討-2013

    • Author(s)
      石川剛、古倉聡、坂元直行、他
    • Organizer
      第26回日本バイオセラピィ学会学術集会
    • Place of Presentation
      盛岡
    • Year and Date
      2013-12-05
    • Related Report
      2013 Final Research Report
  • [Presentation] 皮下腫瘍モデルマウスにおける抗-CTLA-4抗体の効果について2013

    • Author(s)
      足立聡子、古倉聡、岡要、他
    • Organizer
      第72回日本癌学会
    • Place of Presentation
      横浜
    • Year and Date
      2013-10-03
    • Related Report
      2013 Final Research Report
  • [Presentation] 末梢血サイトカインプロファイルからみた膵癌患者のQOL2011

    • Author(s)
      石川剛、古倉聡、坂元直行、他
    • Organizer
      第49回日本癌治療学会学術集会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-10-28
    • Related Report
      2013 Final Research Report
  • [Presentation] Relationship between plasma cytokine levels and physical or psychological functioning in patients with advanced cancer2011

    • Author(s)
      Ishikawa T, Kokura S, Sakamoto N, et al
    • Organizer
      The 2011 European Multidisciplinary Cancer Congress
    • Place of Presentation
      Stockholm, Sweden
    • Year and Date
      2011-09-26
    • Related Report
      2013 Final Research Report
  • [Presentation] Relationship between plasma cytokine levels and physical or psychological functioning in patients with advanced cancer2011

    • Author(s)
      Ishikawa T, Kokura S, et al
    • Organizer
      The 2011 European Multidisciplinary Cancer
    • Place of Presentation
      Stockholm, Sweden
    • Related Report
      2011 Research-status Report
  • [Presentation] Adoptive T cell therapy enhances the secretion ability of cytokines to Th1 and reduces the number of Tregs.2011

    • Author(s)
      Ishikawa T, Kokura S, et al
    • Organizer
      The 2011 European Multidisciplinary Cancer
    • Place of Presentation
      Stockholm, Sweden
    • Related Report
      2011 Research-status Report
  • [Presentation] 未分化型Tリンパ球移入療法の抗腫瘍効果に対する抗CTLA-4抗体の増強効果について

    • Author(s)
      石川剛、足立聡子、岡山哲也、他
    • Organizer
      第26回日本バイオセラピィ学会学術集会総会
    • Place of Presentation
      盛岡
    • Related Report
      2013 Annual Research Report
  • [Presentation] 免疫細胞移入療法における低分化型

    • Author(s)
      石川剛、古倉聡、坂元直行、他
    • Organizer
      第26回日本バイオセラピィ学会学術集会総会
    • Place of Presentation
      盛岡
    • Related Report
      2013 Annual Research Report
  • [Presentation] The efficacy of anti-CTLA-4 antibody in a subcutaneous tumor model mouse

    • Author(s)
      Adachi S, Kokura S, Oka K, et al
    • Organizer
      第72回日本癌学会
    • Place of Presentation
      横浜
    • Related Report
      2013 Annual Research Report
  • [Presentation] Advantages and clinical application of fibronectin CH296-stimulated T cells in cancer immunotherapy

    • Author(s)
      Ishikawa T, Kokura S, Sakamoto N, et al
    • Organizer
      105th AACR Annual Meeting 2014
    • Place of Presentation
      San Diego, CA
    • Related Report
      2013 Annual Research Report
  • [Presentation] Heat treatment inhibits TGF-b-induced Epithelial-Mesenchymal Transition (EMT) in cancer cells

    • Author(s)
      Ishikawa T, kokura S, Sakamoto N, et al
    • Organizer
      Asian Pacific Digestive Week 2012
    • Place of Presentation
      Bangkok, Thailand
    • Related Report
      2012 Research-status Report
  • [Presentation] TGF-beta-induced EMT is inhibited by heat treatment in human colon adenocarcinoma cell line

    • Author(s)
      足立聡子、古倉 聡、石川 剛
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      札幌
    • Related Report
      2012 Research-status Report
  • [Presentation] 進行癌患者に対する免疫細胞療法における末梢血サイトカン産生能、及び制御性T細胞解析による効果予測に関する検討

    • Author(s)
      岡山哲也、石川 剛、足立聡子
    • Organizer
      第25回日本バイオセラピィ学会学術集会総会
    • Place of Presentation
      倉敷
    • Related Report
      2012 Research-status Report
  • [Presentation] 末梢血サイトカイン産生能および制御性T細胞解析による細胞移入療法の効果予測に関する検討

    • Author(s)
      石川 剛、坂元直行、古倉 聡
    • Organizer
      第98回日本消化器病学会総会
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report
  • [Presentation] 新規免疫療法による進行胃癌に対する分子標的薬の抗腫瘍効果増強への試み

    • Author(s)
      岡山哲也、石川 剛、古倉 聡
    • Organizer
      第99回日本消化器病学会学術集会
    • Place of Presentation
      鹿児島
    • Related Report
      2012 Research-status Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi