| Project/Area Number |
23590892
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General internal medicine (including Psychosomatic medicine)
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| Research Institution | Osaka City University |
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Principal Investigator |
KOBAYASHI Hiromi 大阪市立大学, 医学(系)研究科(研究院), 准教授 (10221243)
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| Co-Investigator(Kenkyū-buntansha) |
TAMIYA Hisashi 大阪市立大学, 大学院医学研究科, 講師 (80464634)
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| Research Collaborator |
YANAGIHARA Shigeto 大阪市立大学, 大学院医学研究科, 後期研究医
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
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| Keywords | 補中益気湯 / 紫外線 / 皮膚 / 酸化ストレス / 漢方 |
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| Research Abstract |
Hochuekkito, a traditional Japanese herbal (Kampo) medicine composed of 10 kinds of crude drugs including Astragalus, Ginseng and Bupleurum, has been used for improvement of functional deterioration of the various organs. A randomized control trial has demonstrated its value in the treatment of atopic dermatitis. In this study, we evaluated the functional and histopathological effects of hochuekkito on ultraviolet B (UVB) irradiated mice skin to examine its protective ability against oxidative skin stress. Hochuekkito comprehensively offered a protective effect against UV-B induced skin damage.
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