A study on protective ability of a traditional Japanese herbal medicine against oxidative skin stress

• Project/Area Number: 23590892
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: General internal medicine (including Psychosomatic medicine)
• Research Institution: Osaka City University
• Principal Investigator: KOBAYASHI Hiromi 大阪市立大学, 医学(系)研究科(研究院), 准教授 (10221243)
• Co-Investigator(Kenkyū-buntansha): TAMIYA Hisashi 大阪市立大学, 大学院医学研究科, 講師 (80464634)
• Research Collaborator: YANAGIHARA Shigeto 大阪市立大学, 大学院医学研究科, 後期研究医
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2011: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
• Keywords: 補中益気湯 / 紫外線 / 皮膚 / 酸化ストレス / 漢方

Research Abstract

Hochuekkito, a traditional Japanese herbal (Kampo) medicine composed of 10 kinds of crude drugs including Astragalus, Ginseng and Bupleurum, has been used for improvement of functional deterioration of the various organs. A randomized control trial has demonstrated its value in the treatment of atopic dermatitis. In this study, we evaluated the functional and histopathological effects of hochuekkito on ultraviolet B (UVB) irradiated mice skin to examine its protective ability against oxidative skin stress. Hochuekkito comprehensively offered a protective effect against UV-B induced skin damage.

Research Products

• [Journal Article] Protective effect of hochuekkito, a Kampo prescription, against ultraviolet B irradiation-induced skin damage in hairless mice. (2013)
  • Author(s): Yanagihara S, Kobayashi H, Tamiya H, Tsuruta D, Okano Y, Takahashi K, Masaki H, Yamada T, Hasegawa S, Akamatsu H, Ishii M
  • Journal Title: J Dermatol Volume: 40 Issue: 3 Pages: 201-206
  • DOI: 10.1111/1346-8138.12050
  • Peer Reviewed
• [Presentation] Histopathological study of the effect of Astragalus, Bupleurum and ginseng combination formula, Hochuekkito, a traditional Japanese herbal medicine, against ultraviolet irradiated skin damage in hairless mice (2013)
  • Author(s): Kobayashi H, Yanagihara S, Tamiya H, Tsuruta D, Okano Y, Takahashi K, Masaki H, Yamada T, Hasegawa S, Akamatsu H, Ishii M
  • Organizer: XXXIV Symposium of the International Society of Dermatopathology
  • Place of Presentation: Italy, Florence (Convitto della Calza)
• [Presentation] 紫外線照射による皮膚酸化ストレスと形態学的変化に対する補中益気湯の抑制効果 (2013)
  • Author(s): 柳原茂人、小林裕美、田宮久詩、岡野由利、鶴田大輔、高橋邦明、森亮太、正木仁、山田貴亮、長谷川靖司、赤松浩彦、石井正光
  • Organizer: 第30回和漢医薬学会学術大会
  • Place of Presentation: 金沢市(金沢大学自然科学棟他角間キャンパス)
• [Presentation] 紫外線照射による皮膚酸化ストレスと形態学的変化に対する補中益気湯の抑制効果 (2013)
  • Author(s): 柳原茂人、小林裕美、田宮久詩、岡野由利、 鶴田大輔、高橋邦明、 森亮太、正木仁、 山田貴亮、長谷川靖司、赤松浩彦、 石井正光
  • Organizer: 第30回和漢医薬学会学術大会
  • Place of Presentation: 金沢大学自然科学棟他角間キャンパス、金沢市
• [Presentation] Histopathological study of the effects of Astragalus, Bupleurum and Ginseng combination formula, Hochuekkito, a traditional Japanese herbal medicine, on ultraviolet-irradiated skin damage in hairless mice (2013)
  • Author(s): Hiromi Kobayashi, Shigeto Yanagihara, Hisashi Tamiya, Daisuke Tsuruta, Yuri Okano, Kuniaki Takahashi, Hitoshi Masaki, Takaaki Yamada, Seiji Hasegawa, Hirohiko Akamatsu, Masamitsu Ishii
  • Organizer: XXXIV Symposium of the International Soceity of Dermatopathology
  • Place of Presentation: Convitto della Calza, Florence, Italy
• [Presentation] A"healthy, low-calorie diet"session for the treatment of recalcitrant atopic dermatitis (2012)
  • Author(s): Kobayashi H, Tamiya H, Yanagihara S, Aoki S, Hoshi K, Naruse A, Tateishi C, Nakanishi T, Tsuruta D, Ishii M
  • Organizer: 42^<nd> Annual Meeting of the European Society for Dermatological Research
  • Place of Presentation: Italy, Venice (Palazzo del Casino, Venice Lido Congress Centre)
• [Presentation] A “healthy, low-calorie diet” session for the treatment of recalcitrant atopic dermatitis (2012)
  • Author(s): Kobayashi H, Tamiya H, Yanagihara S, Aoki A, Hoshi K, Naruse A, Tateishi C, Nakanishi T, Tsuruta D, Ishii M
  • Organizer: 42nd Annual Meeting of the European Society for Dermatological Research
  • Place of Presentation: イタリア、ベニス (Palazzo del Casino, Venice Lido Congress Centre)
• [Presentation] Hochuekkito, a Kampo prescription reduced skin oxidative stress indirectly in ultraviolet B-irradiated mice skin. (2012)
  • Author(s): Yanagihara S, Kobayashi H, Tamiya H, Tsuruta D, Nakanishi T, Okano Y, Masaki H, Yamada T, Hasegawa S, Ishii M
  • Organizer: 第37回日本研究皮膚科学会年次学術大会・総会
  • Place of Presentation: 沖縄 (ロワジールホテル＆スパタワー那覇、パシフィックホテル 沖縄)
• [Presentation] Protective effects of a Kampo prescription, hochuekkito, against ultraviolet B-induced oxidative stress in hairless mice skin (2011)
  • Author(s): Kobayashi H, Yanagihara S, Tamiya H, Tsuruta D, Okano Y, Takahashi K, Masaki H, Yamada T, Hasegawa S, Akamatsu H, Ishii M
  • Organizer: 41^<st> Annual Meeting of the European Society for Dermatological Research
  • Place of Presentation: Spain, Barcelona (Barcelona International Convention Centre)
• [Presentation] Protective effects of a Kampo prescription, hochuekkito, against ultraviolet B-induced oxidative stress in hairless mice skin (2011)
  • Author(s): 小林裕美ほか
  • Organizer: 第41回欧州研究皮膚科学会
  • Place of Presentation: バルセロナ
• [Presentation] Hochuekkito, a Kampo prescription reduced skin oxidative stress indirectly in ultraviolet B-irradiated mice skin
  • Author(s): Yanagihara S, Kobayashi H, Tamiya H, Tsuruta S, Nakanishi T, Okano Y, Masaki H, Yamada T, Hasegawa S, Ishii M
  • Organizer: 第37回日本研究皮膚科学会年次学術大会・総会
  • Place of Presentation: 沖縄(ロワジールホテル&スパタワー那覇、パシフィックホテル沖縄)