| Project/Area Number |
23590894
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General internal medicine (including Psychosomatic medicine)
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| Research Institution | Wakayama Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NAKAMURA Takeshi 和歌山県立医科大学, 医学部, 准教授 (80299635)
幸田 剣 和歌山県立医科大学, 医学部, 研究員 (20433352)
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| Co-Investigator(Renkei-kenkyūsha) |
KOUDA Ken 和歌山県立医科大学, 医学部, 博士研究員 (20433352)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 頚下浸水 / 温泉浴 / 中枢温 / 運動療法 / 温熱療法 / インターロイキン－６ / ＴＮＦ－α / サイトカイン / ＴＮＦα / インターロイキン６ / TNFα |
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| Research Abstract |
We hypothesized that head-out hot water immersion (heat stress) increases serum IL-6 in human. Each of 8 healthy adults performed 6 different tests of 30-min rest/20-min intervention/60-min recovery, including rest in air (RA, room temperature 28C), rest during thermoneutral (35.5C) water immersion (RIN), rest during hot (42.0C) water immersion (RIH), exercise in air (EA, ergometer exercise at 60% of VO2max), exercise during thermoneutral water immersion (EIN), and exercise during hot water immersion (EIH). RIH and EIH increased core temperature during and after the immersion and serum levels of IL-6 at recovery period, and the increase in IL-6 level was greater than in RA and RIN. Exercise did not significantly increase IL-6 in EA and EIN. EIH markedly increased IL-6, although the magnitude of the increase was not significantly higher than RIH. These findings demonstrated that hot water immersion increases serum IL-6 through increased body core temperature.
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