| Project/Area Number |
23590898
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General internal medicine (including Psychosomatic medicine)
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| Research Institution | Kumamoto University (2012-2013)
Kanazawa Medical University (2011) |
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Principal Investigator |
NAKAJIMA Hideo 熊本大学, エイズ学研究センター, 客員研究員 (00333394)
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| Co-Investigator(Kenkyū-buntansha) |
MOTOO Yoshiharu 金沢医科大学, 医学部, 教授 (80210095)
KOIZUMI Keita 金沢大学, 子どものこころ発達研究センター, 准教授 (70377406)
MINAMOTO Toshinari 金沢大学, がん進展制御研究所, 教授 (50239323)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 熱ショック蛋白質 / 癌 / ストレス応答 / 発達障害 / FAM107B (HITS) / がん抑制遺伝子 / FAM107 |
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| Research Abstract |
We have identified a unique molecule FAM107B, a novel heat-shock-inducible protein, and designated it HITS. The other FAM107 family protein, FAM107A (TU3A/DRR1), has attracted oncologists as a candidate tumor suppressor gene. Similar to FAM107A, loss of HITS expression is commonly observed in cancers of multiple organs and involved in tumor growth, which contrasts with oncogenic activities of other heat-shock proteins (HSPs) such as HSP70 and HSP90. Because downregulation of HITS expression was marked by histopathological-type and clinical-stage-specific manners in distinct organs, HITS can be a useful marker for diagnosis in various cancers.
Since both HITS and FAM107A expressed strongly in neuronal tissues, we also investigated to elucidate neuronal functions. HITS significantly inhibits neurite outgrowth and cell migration, while FAM107A does not so much.
These results suggest FAM107 family proteins are involved both in oncogenesis and neurogenesis with distinctive functions.
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