| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
|
|---|
| Research Abstract |
The purpose of the present study was to examine possible relationship between kidney function and membrane fluidity of red blood cells (RBCs) in hypertensive and normotensive subjects using an electron spin resonance and spin-labeling method. Membrane fluidity was significantly decreased in hypertensive subjects. The decreased eGFR value might be associated with reduced membrane fluidity of RBCs, suggesting that CKD might have a close correlation with microcirculatory disorders. The reduced levels of both membrane fluidity of RBCs and eGFR were associated with increased plasma 8-iso-prostaglandin F2alpha (an index of oxidative stress) and decreased plasma nitric oxide-metabolites. On the other hand, bone mineral density was significantly lower in hypertensive elderly women than in normotensive elderly women. We propose that CKD-related changes in membrane function and bone-metabolism might have a crucial role in the pathophysiology of hypertension and the metabolic syndrome.
|
