Relationship between longevity marker and serum dehydroepiandrosterone sulfate in epidemiological study

• Project/Area Number: 23590904
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: General internal medicine (including Psychosomatic medicine)
• Research Institution: Kurume University
• Principal Investigator: ENOMOTO Mika 久留米大学, 医学部, 助教 (10360281)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2011: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
• Keywords: 老年医学 / 認知機能 / 予防医学 / 前向き研究

Research Abstract

Dehydroepiandrosterone (DHEA) sulfate are secreted adrenal steroids. DHEAS concentrations decline with age. We investigated whether serum DHEAS levels could predict cognitive function in residents. The study was set as a prospective community-based cohort study. A total of 1940 subjects underwent a health examination in 2009. Serum DHEAS levels were measured by radioimmunoassay at baseline in all subjects, and they were periodically followed until 2014. Baseline DHEAS levels were higher in men than in women and decreased with age in both sexes.In multiple regression analyses adjusted for age and gender, the significance of inverse relationship between MMSE and DHEAS was still remained. This 5-year study in a community-based cohort indicated that DHEAS levels may be a predictor of cognitive function.

Research Products

• [Journal Article] Serum vaspin levels are positively associated with carotid atherosclerosis in a general population (2014)
  • Author(s): Esaki E, Adachi H, Hirai Y, Yamagishi S, Kakuma T, Enomoto M, Fukami A, Kumagai E, Ohbu K, Obuchi A, Yoshimura A, Nakamura S, Nohara Y, Fujiyama T, Fukumoto Y, and Imaizumi T
  • Journal Title: Atherosclerosis Volume: 233 Pages: 248-252
  • Peer Reviewed
• [Journal Article] Serum uric acid is associated with the left ventricular mass index in males of a general population (2014)
  • Author(s): Yoshimura A, Adachi H, Hirai Y, Enomoto M, Fukami A, Kumagai E, Ohbu K, Nakamura S, Obuchi A, Nohara Y, and Imaizumi T
  • Journal Title: International Heart Journal Volume: 55 Pages: 65-70
  • NAID: 130003392056
  • Peer Reviewed
• [Journal Article] New computer model for prediction of individual 10-year mortality on the basis of conventional atherosclerotic risk factors (2013)
  • Author(s): Ogata K, Miyamoto T, Adachi H, Hirai Y, Enomoto M, Fukami A, Yokoi K, Kasahara A, Tsukagawa E, Yoshimura A, Obuchi A, Nakamura S, Imaizumi T
  • Journal Title: Atherosclerosis Volume: 227 Pages: 159-164
  • Peer Reviewed
• [Journal Article] High serum N-acetyl-s-d-glucosaminidase activity is a predictor of 28-year mortality in a population of community-dwelling Japanese-the Tanushimaru study (2013)
  • Author(s): Yoshikawa K, Adachi H, Hirai Y, Enomoto M, Fukami A, Ogata K, Tsukagawa E, Kasahara A, Yokoi K, Okina N, Obuchi A, Yoshimura A, Nakamura S, Imaizumi T
  • Journal Title: Journal of the American Geriatrics Society Volume: 61 Pages: 467-468
  • Peer Reviewed
• [Journal Article] High level of plasma remnant-like particle cholesterol may predispose to development of hypertension in normotensive subjects (2013)
  • Author(s): Kasahara A, Adachi H, Hirai Y, Enomoto M, Fukami A, Yoshikawa K, Esaki E, Yokoi K, Ogata K, Tsukagawa E, Obuchi A, Yoshimura A, Nakamura S, Imaizumi T
  • Journal Title: American Journal of Hypertension Volume: 26 Pages: 793-798
  • Peer Reviewed
• [Journal Article] Independent association of elevated serum hepatocyte growth factor levels with development of insulin resistance in a 10-year prospective study (2013)
  • Author(s): Tsukagawa E, Adachi H, Hirai Y, Enomoto M, Fukami A, Ogata K, Kasahara A, Yokoi K, Imaizumi T
  • Journal Title: Clinical Endocrinology Volume: 79 Pages: 43-48
  • Peer Reviewed
• [Journal Article] High serum N-acetyl-ß-d-glucosaminidase activity is a predictor of 28-year mortality in a population of community-dwelling Japanese-the Tanushimaru study (2013)
  • Author(s): K Yoshikawa, H Adachi, Y Hirai, M Enomoto, A Fukami, K Ogata, E Tsukagawa, A Kasahara, K Yokoi, N Okina, A Obuchi, A Yoshimura, S Nakamura, T Imaizumi
  • Journal Title: Journal of the American Geriatrics Society Volume: 61 Pages: 467-468
  • Peer Reviewed
• [Journal Article] Plasma endothelin-1 level is a predictor of 10-year mortality in a general population : the Tanushimaru study (2012)
  • Author(s): Yokoi K, Adachi H, Hirai Y, Enomoto M, Fukami A, Ogata K, Tsukagawa E, Kasahara A, Imaizumi T
  • Journal Title: Circulation Journal Volume: 76 Pages: 2779-2784
  • NAID: 10031126048
  • Peer Reviewed
• [Journal Article] Serum hepatocyte growth factor and cancer mortality in an apparently healthy Japanese population (2012)
  • Author(s): Otsuka M, Adachi H, Jacobs DR Jr, Hirai Y, Enomoto M, Fukami A, Kumagae S, Nanjo Y, Yoshikawa K, Esaki E, Kumagai E, Yokoi K, Ogata K, Tsukagawa E, Kasahara A, Ohbu K, Imaizumi T
  • Journal Title: Journal of Epidemiology Volume: 22 Pages: 395-401
  • NAID: 10031028775
  • Peer Reviewed
• [Journal Article] Plasma aldosterone levels and development of insulin resistance : prospective study in a general population (2011)
  • Author(s): Kumagai E, Adachi H, Jacobs DR Jr, Hirai Y, Enomoto M, Fukami A, Otsuka M, Kumagae S, Nanjo Y, Yoshikawa K, Esaki E, Yokoi K, Ogata K, Kasahara A, Tsukagawa E, Ohbu-Murayama K, Imaizumi T
  • Journal Title: Hypertension Volume: 58 Pages: 1043-1048
  • Peer Reviewed
• [Journal Article] LDL-C/HDL-C Ratio Predicts Carotid Intima-Media Thickness Progression Better Than HDL-C or LDL-C Alone (2011)
  • Author(s): Enomoto M, Adachi H, Hirai Y, Fukami A, Satoh A, Otsuka M, Kumagae S, Nanjo Y, Yoshikawa K, Esaki E, Kumagai E, Ogata K, Kasahara A, Tsukagawa E, Yokoi K, Ohbu-Murayama K, Imaizumi T.
  • Journal Title: Journal of Lipids Volume: 2011 Pages: 549137-549137
  • Peer Reviewed
• [Presentation] Plasma endothelin-1 level is a predictor of 10-year mortality in a general population : THE TANUSHIMARU STUDY (2013)
  • Author(s): Yokoi K, Adachi, Hirai Y, Enomoto M, Fukami A, Ogata K, Tsukagawa E, Kasahara A, Imaizumi T
  • Organizer: International Conference on Endothelin
  • Place of Presentation: Tokyo, Japan
• [Presentation] Combined Elevations of Asymmetric Dimethylarginine and Homocysteine have Big Impact on Carotid Atherosclerosis―The Tanushimaru Study― (2013)
  • Author(s): Nohara Y, Yoshida K, Adachi H, Hirai Y, Enomoto M, Fukami A, Kumagai E, Ohbu-Murayama K, Nakamura S, Obuchi A, Yoshimura A, Imaizumi T
  • Organizer: The American Heart Association, 86th Scientific Sessions
  • Place of Presentation: Dallas, USA
• [Presentation] 熱ショック蛋白は、多量喫煙者と高尿酸血症者において増加する～一般住民における疫学的検討～ (2013)
  • Author(s): 大部恭子、足達寿、平井祐治、榎本美佳、深水亜子、大塚麻樹、吉田久美子、熊谷英太、中村佐知子、大渕綾、吉村彩子、野原夢、福本義弘、今泉勉
  • Organizer: 第36回日本高血圧学会学術集会
  • Place of Presentation: 大阪
• [Presentation] 血清フェチュインA値とインスリン抵抗性との関連:一般住民検診における疫学的検討 (2013)
  • Author(s): 大渕綾、足達寿、平井祐治、榎本美佳、深水亜子、吉川邦子、緒方絹歌、笠原明子、塚川絵理、横井加奈子、大部恭子、吉村彩子、中村佐知子、野原夢、今泉勉
  • Organizer: 第49回日本循環器病予防学会
  • Place of Presentation: 金沢市
• [Presentation] 2013 Association of serum omega-3 to omega-6 polyunsaturated fatty acid ratio with microalbuminuria in a population of community-dwelling Japanese (2013)
  • Author(s): Fukami A, Adachi H, Hirai Y, Enomoto M, Obuchi A, Yoshimura A, Imaizumi T
  • Organizer: The 81^<st> European Atherosclerosis Society Congress
  • Place of Presentation: Lyon, France
• [Presentation] Urinary liver-type fatty acid binding protein is associated with microalbuminuria as well as insulin resistance in a general population (2013)
  • Author(s): Fukami A, Adachi H, Hirai Y, Enomoto M, Otsuka M, Kumagae S, Nanjo Y, Yoshikawa K, Esaki E, Yokoi K, Ogata K, Tsukagawa E, Kasahara A, Ohbu-Murayama K, Obuchi A, Yoshimura A, Imaizumi T
  • Organizer: 第78回日本循環器学会総会学術集会
  • Place of Presentation: 横浜
• [Presentation] Plasma fetuin-A levels is associated with insulin resistance in a population of community-dwelling Japanese (The second report in Uku-study) (2013)
  • Author(s): Obuchi A, Nohara Y, Adachi H, Hirai Y, Enomoto M, Fukami A, Yoshikawa K, Otsuka M, Esaki E, Tsukagawa EYokoi K, Ogata K, Kasahara A, Ohbu-Murayama K, Imaizumi T
  • Organizer: 第78回日本循環器学会総会学術集会
  • Place of Presentation: 横浜
• [Presentation] 一般住民における血清尿酸血と左室重量係数の関連 (2013)
  • Author(s): 吉村彩子、足達寿、平井祐治、榎本美佳、深水亜子、吉川邦子、緒方絹歌、笠原明子、塚川絵理、横井加奈子、大部恭子、大渕綾、中村佐知子、今泉勉
  • Organizer: 第23回日本疫学会学術総会
  • Place of Presentation: 大阪
• [Presentation] 血清フェチュインA値とインスリン抵抗性との関連-一般住民における疫学的検討- (2013)
  • Author(s): 大渕綾、足達寿、平井祐治、榎本美佳、深水亜子、吉川邦子、緒方絹歌、笠原明子、塚川絵理、横井加奈子、大部恭子、吉村彩子、中村佐知子、今泉勉
  • Organizer: 第23回日本疫学会学術総会
  • Place of Presentation: 大阪
• [Presentation] 一般住民検診における内臓脂肪測定の意義 (2012)
  • Author(s): 榎本美佳、足達寿、平井祐治、今泉勉
  • Organizer: 第4回福岡県医学会総会
  • Place of Presentation: 福岡
  • Year and Date: 2012-01-29
• [Presentation] Hepatocyte growth factor resistance may precede development of insulin resistance in adults : prospective study in a general population (2012)
  • Author(s): Tsukagawa Eri, Hisashi Adachi, Yuji Hirai, Mika Enomoto, Ako Fukami, Maki Otsuka, Kuniko Yoshikawa, Eishi Esaki, Kinuka Ogata, Akiko Kasahara, Kanako Yokoi, Kyouko Ohbu, Ayako Yoshimura, Aya Ohbuchi, Tsutomu Imaizumi
  • Organizer: The American Heart Association, 85th Scientific Sessions
  • Place of Presentation: Los Angeles, USA
• [Presentation] The ratio of serum eicosapentaenoic acid to arachidonic acid is inversely associated with microalbuminuria in a population of community-dwelling Japanese (2012)
  • Author(s): Fukami Ako, Hisashi Adachi, Yuji Hirai, Mika Enomoto, Kuniko Yoshikawa, Eishi Esaki, Kinuka Ogata, Akiko Kasahara, Eri Tsukagawa, Kanako Yokoi, Takanobu Miyamoto, Aya Obuchi, Ayako Yoshimura, Sachiko Nakamura, Tsutomu Imaizumi
  • Organizer: The American Heart Association, 85th Scientific Sessions
  • Place of Presentation: Los Angeles, USA
• [Presentation] A new measurement system of visceral fat area by bioelectrical impedance analysis in a population of community-dwelling Japanese (2012)
  • Author(s): Mika Enomoto, Hisashi Adachi, Yuji Hirai, Ako Fukami, Kuniko Yoshikawa, Eishi Esaki, Kinuka Ogata, Akiko Kasahara, Eri Tsukagawa, Kanako Yokoi, Sachiko Nakamura, Aya Obuchi, Ayako Yoshimura, Tsutomu Imaizumi
  • Organizer: The American Heart Association, 85th Scientific Sessions
  • Place of Presentation: Los Angeles, USA
• [Presentation] 一般住民検診における内臓脂肪面積測定の意義 (2012)
  • Author(s): 榎本美佳、足達寿、平井祐治、深水亜子、大塚麻樹、吉川邦子、熊谷英太、江崎英司、緒方絹歌、笠原明子、塚川絵理、横井加奈子、大部恭子、今泉勉
  • Organizer: 第35回日本高血圧学会学術集会
  • Place of Presentation: 名古屋
• [Presentation] Serum fetuin-A levels are inversely associated with carotid plaque in a population of community-dwelling Japanese (2012)
  • Author(s): Obuchi A, Adachi H, Hirai Y, Enomoto M, Fukami A, Yoshimura A, Nakamura S, Tsukagawa E, Yokoi K, Ogata K, Kasahara A, Ohbu-Murayama K, Imaizumi T
  • Organizer: The Asia Pacific Stroke Conference
  • Place of Presentation: Tokyo, Japan
• [Presentation] Combined elevations of asymmetric dimethylarginine and homocysteine have big impact on carotid atherosclerosis : The Tanushimaru Study (2012)
  • Author(s): Adachi H, Yoshida K, Hirai Y, Enomoto M, Fukami A, Obuchi A, Yoshimura A, Nakamura S, Imaizumi T
  • Organizer: The Asia Pacific Stroke Conference
  • Place of Presentation: Tokyo, Japan
• [Presentation] 一般住民検診における内臓脂肪面積測定の意義 (2012)
  • Author(s): 榎本美佳、平井祐治、足達寿
  • Organizer: 第48回日本循環器病予防学会
  • Place of Presentation: 東京
• [Presentation] A new measurement system of visceral fat area by bioelectrical impedance analysis in a general population (2012)
  • Author(s): Enomoto M, Adachi H, Hirai Y, Fukami A, Otsuka M, Kumagai E, Esaki E, Yoshikawa K, Ogata K, Tsukagawa E, Kasahara A, Yokoi K, Ohbu-Murayama K, Ohbuchi A, Yoshimura A, Imaizumi T
  • Organizer: 22^<st> European meeting on hypertension and cardiovascular prevention
  • Place of Presentation: London, England
• [Presentation] Serum uric acid is strongly associated with the left ventricular mass index in a general population (2012)
  • Author(s): Yoshimura A, Adachi H, Hirai Y, Enomoto M, Fukami A, Yoshikawa K, Otsuka M, Kumagai E, Esaki E, Ogata K, Kasahara A, Yokoi K, Ohbu-Murayama K, Ohbuchi A, Miyamoto T, Imaizumi T
  • Organizer: 22^<st> European meeting on hypertension and cardiovascular prevention
  • Place of Presentation: London, England
• [Presentation] Plasma fetuin-A levels is associated with insulin resistance in a general population (2012)
  • Author(s): Obuchi A, Adachi H, Hirai Y, Enomoto M, Fukami A, Yoshikawa K, Otsuka M, Kumagai E, Esaki E, Tsukagawa E, Yokoi K, Ogata K, Kasahara A, Ohbu-Murayama K, Imaizumi T
  • Organizer: 22^<st> European meeting on hypertension and cardiovascular prevention
  • Place of Presentation: London, England
• [Presentation] New Measurement System of Visceral Fat Area by Bioelectrical Impedance Analysis in a General Population (2012)
  • Author(s): Mika Enomoto
  • Organizer: 欧州高血圧学会
  • Place of Presentation: ロンドン
• [Presentation] A New Measurement System of Visceral Fat Area by Bioelectrical Impedance Analysis in a Population of community-Dwelling (2012)
  • Author(s): Mika Enomoto
  • Organizer: 米国心臓病学会
  • Place of Presentation: ロサンゼルス