Establishment of new strategy for preventing the prothrombotic tendency of metabolic syndrome
| Project/Area Number |
23590905
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General internal medicine (including Psychosomatic medicine)
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| Research Institution | Nakamura Gakuen College |
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Principal Investigator |
HIROKO Tsuda 中村学園大学, 栄養科学部, 教授 (30180003)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | メタボリックシンドローム / 向血栓症 / プロテインS / プロテインC / ApoCII / 向血栓性 / アポプロテイン / プロテインＳ / リポタンパク質 / 血栓症 / 食事因子 / アディポサイトカイン / 肝細胞 |
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| Research Abstract |
Protein S (PS) is an anticoagulant factor that plays an important role in the protein C (PC) anticoagulant pathway, and its dysfunction is a main thrombophilia among Japanese. The clinical studies on obese women and young adult women uncovered that total PS mass concentration in plasma is positively correlated with the amounts of PC and ApoCII. The PS mRNA expression in HepG2 cells, a human hepatoma cell line, is decreased by adding resveratrol, a polyphenol present in wine, and by lowering the glucose concentration in culture medium. These results suggest that PS in plasma may bind with lipoproteins, such as VLDL and IDL, and protect the prothrombotic tendency of metabolic syndrome.
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Report
(4 results)
Research Products
(66 results)
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[Journal Article] Discontinuation of leisure time impact-loading exercise is related to reduction of a calcaneus quantitative ultrasound parameter in young adult Japanese females: a 3-year follow-up study.2014
Author(s)
Nakazono E., Miyazaki H., Abe S., Imai K., Masuda T., Iwamoto M., Moriguchi R., Ueno H., Ono M., Yazumi K., Moriyama K., Nakano S., and Tsuda H.
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Journal Title
Osteoporos Int.
Volume: 25
Issue: 2
Pages: 485-495
DOI
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Peer Reviewed
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[Presentation] Discontinuation of impact-loading exercise is related to reduction of a calcaneus quantitative ultrasound parameter in young adult Japanese females: a 3-year follow-up study.
Author(s)
Nakazono E., Miyazaki H., Abe S., Imai K., Masuda T., Iwamoto M., Moriguchi R., Ueno H., Ono M., Yazumi K., Moriyama K., Nakano S., Tsuda H.
Organizer
2nd Joint Meeting of the Int. Bone & Mineral Soc. and the Japanese Soc. for Bone & Mineral Res.
Place of Presentation
Kobe (Kobe international conference center)
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[Presentation] Charting of daily weight pattern introduced into group therapy reinforces the synergistic effect on weight reduction in obese patients.
Author(s)
Ueno H., Miyazaki H., Abe S., Imai K., Masuda T., Koga R., Tsuda H., Iwamoto M., Nakazono E., Ono M., Yazumi K., Moriyama K., Oobe M., Aishima E., Nakano S., Sakata T.
Organizer
16th Int. Congr. Dietetics.
Place of Presentation
International Congress Center (Sydney, Australia)
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