| Project/Area Number |
23590914
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Nagoya University |
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Principal Investigator |
MAEDA Osamu 名古屋大学, 医学(系)研究科(研究院), 特任助教 (20378053)
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| Co-Investigator(Kenkyū-buntansha) |
ANDO Takafumi 名古屋大学, 医学系研究科, 准教授 (80378041)
ISHIGURO Kazuhiro 名古屋大学, 医学系研究科, 特任准教授 (60432275)
WATANABE Osamu 名古屋大学, 医学部附属病院, 病院講師 (80378059)
OHMIYA Naoki 名古屋大学, 医学部, 准教授 (00335035)
MIYAHARA Ryoji 名古屋大学, 医学部附属病院, 助教 (50378056)
GOTO Hidemi 名古屋大学, 医学系研究科, 教授 (10215501)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 消化器癌 / 薬剤耐性 / 遺伝子発現 / ＤＮＡメチル化 / マイクロアレイ / DNAメチル化 / 化学療法 |
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| Research Abstract |
The aim of this study is to establish a method to optimal choice of treatment by analyzing correlation between biological features of tumor including DNA methylation and gene expression and clinical courses of gastrointestinal cancer. We established drug-resistant cancer cell line by exposure with anticancer drugs, and obtained endoscopic biopsy specimens before and after chemotherapy. We performed genome-wide analysis with microarray. We analyzed DNA methylation and gene expression profiles related with drug-resistant of gastrointestinal cancer. And we extracted genes that were considered to be important for drug-resistant mechanisms using quantitative methods.
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