Evaluation of the functional role of Notch signaling in the development of Barrett's esophagus: interaction with Cdx2 pathway
Project/Area Number |
23590917
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Gastroenterology
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Research Institution | Shimane University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
AMANO Yuji 国際医療福祉大学, 保健医療学部, 教授 (80284032)
|
Project Period (FY) |
2011 – 2013
|
Project Status |
Completed (Fiscal Year 2013)
|
Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
Keywords | バレット食道 / シグナル伝達 / Notchシグナル / Cdx2 / Notch / Dll-1 |
Research Abstract |
The relationship between the Notch signaling pathway and Cdx2 expression in the development of Barrett's esophagus has not been explored. The aim of this study was to investigate the interrelationship between Notch signaling and Cdx2 in esophageal epithelial cells. Forced expression of Cdx2 in cells suppressed Hes1, and enhanced ATOH1, Dll-1 and MUC2 expressions, whereas bile acids suppressed Hes1, and enhanced ATOH1, Dll-1, Cdx2, and MUC2 expressions. On the other hand, these effects were blocked by siRNA-based Cdx2 downregulation. We also found that both ATOH1 and Cdx2 expression were enhanced during development of Barrett's esophagus in rat model. Collectively, enhanced expression of Cdx2 by stimulation with bile acids may induce intestinal differentiation of esophageal columnar cells by interaction with the Notch signaling pathway including ATOH1 and Dll-1.
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Report
(4 results)
Research Products
(90 results)
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[Journal Article] Clinical characteristics of Japanese patients with eosinophilic esophagitis and eosinophilic gastroenteritis2013
Author(s)
Kinoshita Y, Furuta K, Ishimura N, Ishihara S, Sato S, Maruyama R, Ohara S, Matsumoto T, Sakamoto C, Matsui T, Ishikawa S, Chiba T
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Journal Title
J Gastroenterol
Volume: 43
Pages: 333-339
URL
Related Report
Peer Reviewed
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[Journal Article] Capnographic monitoring for carbon dioxide insufflation during endoscopic submucosal dissection : comparison of transcutaneous and end-tidal capnometers2012
Author(s)
Kusunoki R, Amano Y, Yuki T, Oka A, Okada M, Tada Y, Uno G, Moriyama I, Ishimura N, Ishihara S, Kinoshita Y
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Journal Title
Surg Endosc
Volume: 26
Issue: 2
Pages: 501-506
DOI
Related Report
Peer Reviewed
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[Journal Article] Barrett's esophagus : proton pump inhibitors and chemoprevention I2011
Author(s)
Triadafilopoulos G, Taddei A, Bechi P, Freschi G, Ringressi MN, Degli'Innocenti DR, Castiglione F, Masini E, Majewski M, Wallner G, Sarosiek J, Dillon JF, McCallum RC, Dvorak K, Goldman A, Woodland P, Sifrim D, Richter JE, Vieth M, Neumann H, Langner C, Ishimura N, Amano Y, Felix VN
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Journal Title
Ann N Y Acad Sci
Volume: 1232
Issue: 1
Pages: 93-113
DOI
Related Report
Peer Reviewed
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[Journal Article] Fatty acid synthase expression in Barrett's esophagus : implications for carcinogenesis2011
Author(s)
Ishimura N, Amano Y, Sanchez-Siles AA, Fukuhara H, Takahashi Y, Uno G, Tamagawa Y, Mishima Y, Yuki T, Ishihara S, Kinoshita Y
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Journal Title
J Clin Gastroenterology
Volume: 45
Issue: 8
Pages: 665-672
DOI
Related Report
Peer Reviewed
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