| Project/Area Number |
23590923
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Nagoya City University |
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Principal Investigator |
KATAOKA Hiromi 名古屋市立大学, 医学(系)研究科(研究院), 准教授 (40381785)
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| Co-Investigator(Kenkyū-buntansha) |
YANO Shigenobu 奈良先端科学技術大学院大学, 物質創成科・学研究科, 教授 (60011186)
JOH Takashi 名古屋市立大学, 大学院医学研究科, 教授 (30231369)
TANAKA Mamoru 名古屋市立大学, 大学院医学研究科, 臨床研究医 (80617861)
SUZUKI Shuugo 名古屋市立大学, 大学院医学研究科, 研究員 (60363933)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | PDT / 胃癌 / GIST / 光線力学的治療法 |
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| Research Abstract |
Except for surgical resection, no effective treatment strategies have been established for gastrointestinal stromal tumors (GISTs). Photodynamic therapy (PDT) consists of intravenous administration of a photosensitizer, activated by a specific wavelength of light, which produces reactive oxygen species that directly kill tumor cells. We analyzed the efficacy of PDT using a newly developed photosensitizer, glucose-conjugated chlorin (G-chlorin) for the GIST treatment. In vitro, the expression of the glucose transporters GLUT1, GLUT3, and GLUT4, the cellular uptake of G-chlorin, and apoptosis mediated by PDT with G-chlorin were significantly higher in GIST-T1 than in WI-38 cells. In vivo, G-chlorin accumulation was higher in xenograft tumors of GIST-T1 cells than in the adjacent normal tissue, and tumor growth was significantly suppressed following PDT.
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