Development of novel PDT with glucose-conjugated chlorin for gastric cancer and GIST
| Project/Area Number |
23590923
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Nagoya City University |
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Principal Investigator |
KATAOKA Hiromi 名古屋市立大学, 医学(系)研究科(研究院), 准教授 (40381785)
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| Co-Investigator(Kenkyū-buntansha) |
YANO Shigenobu 奈良先端科学技術大学院大学, 物質創成科・学研究科, 教授 (60011186)
JOH Takashi 名古屋市立大学, 大学院医学研究科, 教授 (30231369)
TANAKA Mamoru 名古屋市立大学, 大学院医学研究科, 臨床研究医 (80617861)
SUZUKI Shuugo 名古屋市立大学, 大学院医学研究科, 研究員 (60363933)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | PDT / 胃癌 / GIST / 光線力学的治療法 |
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| Research Abstract |
Except for surgical resection, no effective treatment strategies have been established for gastrointestinal stromal tumors (GISTs). Photodynamic therapy (PDT) consists of intravenous administration of a photosensitizer, activated by a specific wavelength of light, which produces reactive oxygen species that directly kill tumor cells. We analyzed the efficacy of PDT using a newly developed photosensitizer, glucose-conjugated chlorin (G-chlorin) for the GIST treatment. In vitro, the expression of the glucose transporters GLUT1, GLUT3, and GLUT4, the cellular uptake of G-chlorin, and apoptosis mediated by PDT with G-chlorin were significantly higher in GIST-T1 than in WI-38 cells. In vivo, G-chlorin accumulation was higher in xenograft tumors of GIST-T1 cells than in the adjacent normal tissue, and tumor growth was significantly suppressed following PDT.
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Report
(4 results)
Research Products
(31 results)
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[Journal Article] Antitumor effects in gastrointestinal stromal tumors using photodynamic therapy with a novel glucose-conjugated chlorin2014
Author(s)
Tanaka M, Kataoka H, Yano S, Ohi H, Moriwaki K, Akashi H, Taguchi T, Hayashi N, Hamano S, Mori Y, Kubota E, Tanida S, Joh T
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Journal Title
Mol Cancer Ther
Pages: 767-75
Related Report
Peer Reviewed
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[Journal Article] Management of systolic blood pressure after endoscopic submucosal dissection is crucial for prevention of postgastric bleeding.2014
Author(s)
Ebi M, Shimura T, Nishiwaki H, Tanaka M, Tsukamoto H, Ozeki K, Sawada T, Mizoshita T, Mori Y, Kubota E, Tanida S, Kataoka H, Joh T.
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Journal Title
Eur J Gastroenterol Hepatol
Volume: 26(5)
Issue: 5
Pages: 504-9
DOI
Related Report
Peer Reviewed
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[Journal Article] Antitumor effects in gastrointestinal stromal tumors using photodynamic therapy with a novel glucose-conjugated chlorin.2014
Author(s)
Tanaka M, Kataoka H, Yano S, Ohi H, Moriwaki K, Akashi H, Taguchi T, Hayashi N, Hamano S, Mori Y, Kubota E, Tanida S, Joh T.
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Journal Title
Mol Cancer Ther.
Volume: Feb 19.
Pages: 767-75
Related Report
Peer Reviewed
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[Journal Article] Anti-cancer effects of newly developed chemotherapeutic agent, glycoconjugated palladium (II) complex, against cisplatin-resistant gastric cancer cells.2013
Author(s)
Tanaka M, Kataoka H, Yano S, Ohi H, Kawamoto K, Shibahara T, Mizoshita T, Mori Y, Tanida S, Kamiya T, Joh T.
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Journal Title
BMC Cancer
Volume: May 14;13:237
Issue: 1
Pages: 41-47
DOI
Related Report
Peer Reviewed
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[Journal Article] Diagnostic utility of small-caliber and conventional endoscopes for gastric cancer and analysis of endoscopic false-negative gastric cancers.2013
Author(s)
Kataoka H, Mizuno K, Hayashi N, Tanaka M, Nishiwaki H, Ebi M, Mizoshita T, Mori Y, Kubota E, Tanida S, Kamiya T, Joh T.
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Journal Title
World J Gastrointest Endosc.
Volume: 16;5(9)
Issue: 9
Pages: 440-5
DOI
Related Report
Peer Reviewed
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