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Association between Helicobacter pylori infection and bronchial asthma

Research Project

Project/Area Number 23590924
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Gastroenterology
Research InstitutionOsaka City University

Principal Investigator

ARAKAWA Tetsuo  大阪市立大学, 医学(系)研究科(研究院), 教授 (60145779)

Co-Investigator(Kenkyū-buntansha) FUJIWARA Yasuhiro  大阪市立大学, 大学院医学研究科, 准教授 (40285292)
TOMINAGA Kazunari  大阪市立大学, 大学院医学研究科, 准教授 (80336768)
WATANABE Toshio  大阪市立大学, 大学院医学研究科, 准教授 (50336773)
TANIGAWA Tetsuya  大阪市立大学, 大学院医学研究科, 講師 (70423879)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywordsヘリコバクター・ピロリ / 気管支喘息 / 喘息 / ヘリコバクター / ヘリコバクターピロリ
Research Abstract

Helicobacter pylori infection is pathogens associated with gastritis, peptic ulcers, and gastric cancer. However, epidemiological studies showed a negative association between H. pylori infection and development of bronchial asthma. The aim of the present project was to determine whether H. pylori infection affects development of bronchial asthma in an animal model. We examined effect of H. pylori infection on severity of ovalbumin- induced asthma in Mongolian gerbil. Ovalbumin induced similar severity of asthma, infiltration of inflammatory cells, cytokines, histological changes in both H. pylori infected and non-infected mice. H. pylori infection might not be associated with development of bronchial asthma.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (27 results)

All 2014 2013 2012 2011 Other

All Journal Article (18 results) (of which Peer Reviewed: 18 results) Presentation (5 results) Book (3 results) Remarks (1 results)

  • [Journal Article] Anti-tumour necrosis factor agents reduce non-steroidal anti-inflammatory drug-induced small bowel injury in rheumatoid arthritis patients.2014

    • Author(s)
      Watanabe T, Tanigawa T, Shiba M, Nadatani Y, Nagami Y, Sugimori S, Yamagami H, Watanabe K, Tominaga K, Fujiwara Y, Koike T, Arakawa T.
    • Journal Title

      Gut

      Volume: 63 Issue: 3 Pages: 409-414

    • DOI

      10.1136/gutjnl-2013-304713

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Role of small intestinal bacterial overgrowth in severe small intestinal damage in chronic non-steroidal anti-inflammatory drug users.2014

    • Author(s)
      Muraki M, Fujiwara Y, Machida H, Okazaki H, Sogawa M, Yamagami H, Tanigawa T, Shiba M, Watanabe K, Tominaga K, Watanabe T, Arakawa T.
    • Journal Title

      Scand J Gastroenterol

      Volume: 49 Pages: 267-273

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Infliximab and/or immunomodulators inhibit immune responses to trivalent influenza vaccination in adults with inflammatory bowel disease.2014

    • Author(s)
      Hagihara Y, Ohfuji S, Watanabe K, Yamagami H, Fukushima W, Maeda K, Kamata N, Sogawa M, Shiba M, Tanigawa T, Tominaga K, Watanabe T, Fujiwara Y, Hirota Y, Arakawa
    • Journal Title

      J Crohns Colitis.

      Volume: 8 Issue: 3 Pages: 223-233

    • DOI

      10.1016/j.crohns.2013.08.008

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Rebamipide inhibits indomethacin-induced small intestinal injury : possible involvement of intestinal microbiota modulation by upregulation ofα-defensin 52013

    • Author(s)
      Tanigawa T, Watanabe T, Otani K, Nadatani Y, Ohkawa F, Sogawa M, Yamagami H, Shiba M, Watanabe K, Tominaga K, Fujiwara Y, Takeuchi K, Arakawa T
    • Journal Title

      Eur J Pharmacol

      Volume: 704 Issue: 1-3 Pages: 64-9

    • DOI

      10.1016/j.ejphar.2013.02.010

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] High-mobility group box 1 inhibits gastric ulcer healing through Toll-like receptor 4 and receptor for advanced glycation end products.2013

    • Author(s)
      Nadatani Y, Watanabe T, Tanigawa T, Ohkawa F, Takeda S, Higashimori A, Sogawa M, Yamagami H, Shiba M, Watanabe K, Tominaga K, Fujiwara Y, Takeuchi K, Arakawa T.
    • Journal Title

      PLoS One

      Volume: 8 Issue: 11 Pages: e80130-e80130

    • DOI

      10.1371/journal.pone.0080130

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mesenchymal stem cells administered in the early phase of tumorigenesis inhibit colorectal tumor development in rats2013

    • Author(s)
      Katsuno T, Ochi M, Tominaga K, Tanaka F, Sogawa M, Tanigawa T, Yamagami H, Shiba M, Watanabe K, Watanabe T, Fujiwara Y, Arakawa T.
    • Journal Title

      Journal of Clinical Biochemistry and Nutrition

      Volume: 53 Issue: 3 Pages: 170-175

    • DOI

      10.3164/jcbn.13-68

    • NAID

      130004466728

    • ISSN
      0912-0009, 1880-5086
    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A multicenter study on the prevalence of Eosinophilic Esophagitis and PPI-responsive esophageal eosinophilic infiltration2012

    • Author(s)
      Fujiwara Y, Sugawa T, Tanaka F, Tatsuwaki H, Okuyama M, Hayakawa T, Yamamori K, Wada R, Ohtani K, Uno H, Tanigawa T, Watanabe Y, Tominaga K, Watanabe T, Takaishi O, Saeki Y, Nebiki H, Oshitani N, Sato H, Arakawa T
    • Journal Title

      Intern Med

      Volume: 51 Pages: 3235-9

    • NAID

      130003308153

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Toll-like receptor 9 signaling has anti-inflammatory effects on the early phase of Helicobacter pylori-induced gastritis.2012

    • Author(s)
      Otani K, Tanigawa T, Watanabe T, Nadatani Y, Sogawa M, Yamagami H, Shiba M, Watanabe K, Tominaga K, Fujiwara Y, Arakawa T.
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 426 Issue: 3 Pages: 342-9

    • DOI

      10.1016/j.bbrc.2012.08.080

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Activation of the MyD88 signaling pathway inhibits ischemia-reperfusion injury in the small intestine2012

    • Author(s)
      Watanabe T, Kobata A, Tanigawa T, Nadatani Y, Yamagami H, Watanabe K, Tominaga K, Fujiwara Y, Takeuchi K, Arakawa T
    • Journal Title

      Am J Physiol Gastrointest Liver Physiol

      Volume: 303 Issue: 3 Pages: G324-G334

    • DOI

      10.1152/ajpgi.00075.2012

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] High mobility group box 1 promotes small intestinal damage induced by nonsteroidal anti-inflammatory drugs through Toll-like receptor 4.2012

    • Author(s)
      Nadatani Y, Watanabe T, Tanigawa T, Machida H, Okazaki H, Yamagami H, Watanabe K, Tominaga K, Fujiwara Y, Arakawa T
    • Journal Title

      Am J Pathol.

      Volume: 181 Issue: 1 Pages: 98-110

    • DOI

      10.1016/j.ajpath.2012.03.039

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Small intestinal injury caused by NSAIDs/aspirin : finding new from old2012

    • Author(s)
      Arakawa T, Watanabe T, Tanigawa T, Tominaga K, Otani K, Nadatani Y, Fujiwara Y
    • Journal Title

      Curr Med Chem

      Volume: 19 Issue: 1 Pages: 77-81

    • DOI

      10.2174/092986712803414105

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Activation of the MyD88 signaling pathway inhibits ischemia-reperfusion injury in the small intestine.2012

    • Author(s)
      Watanabe T, Kobata A, Tanigawa T, Nadatani Y, Yamagami H, Watanabe K, Tominaga K, Fujiwara Y, Takeuchi K, Arakawa T
    • Journal Title

      Am J Physiol Gastrointest Liver Physiol.

      Volume: 303

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Small intestinal injury caused by NSAIDs/aspirin: finding new from old.2012

    • Author(s)
      Arakawa T, Watanabe T, Tanigawa T, Tominaga K, Otani K, Nadatani Y, Fujiwara Y.
    • Journal Title

      Curr Med Chem.

      Volume: 19 Pages: 77-81

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Role of Th-2 cytokines in the development of Barrett's esophagus in rats2011

    • Author(s)
      Kohata Y, Fujiwara Y, Machida H, Okazaki H, Yamagami H, Tanigawa T, Watanabe K, Watanabe T, Tominaga K, Wei M, Wanibuchi H, Arakawa T
    • Journal Title

      J Gastroenterol

      Volume: 46 Issue: 7 Pages: 883-93

    • DOI

      10.1007/s00535-011-0405-y

    • NAID

      10029313176

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Dysregulated upregulation of T-cell immunoglobulin and mucin domain-3 on mucosal T helper 1 cells in patients with Crohn's disease2011

    • Author(s)
      Morimoto K, Hosomi S, Yamagami H, Watanabe K, Kamata N, Sogawa M, Machida H, Okazaki H, Tanigawa T, Nagahara H, Noda E, Tominaga K, Watanabe T, Fujiwara Y, Maeda K, Hirakawa K, Arakawa T
    • Journal Title

      Scand J Gastroenterol

      Volume: 46 Issue: 6 Pages: 701-9

    • DOI

      10.3109/00365521.2011.568518

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Dysregulated upregulation of T-cell immunoglobulin and mucin domain-3 on mucosal T helper 1 cells in patients with Crohn's disease.2011

    • Author(s)
      Morimoto K, Hosomi S, Yamagami H, Watanabe K, Kamata N, Sogawa M, Machida H, Okazaki H, Tanigawa T, Nagahara H, Noda E, Tominaga K, Watanabe T, Fujiwara Y, Maeda K, Hirakawa K, Arakawa T.
    • Journal Title

      Scand J Gastroenterol

      Volume: 46 Pages: 701-9

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Association between left-handedness and gastrointestinal symptoms.2011

    • Author(s)
      Fujiwara Y, Kubo M, Kohata Y, Yamagami H, Tanigawa T, Watanabe K, Watanabe T, Tominaga K, Arakawa T.
    • Journal Title

      Digestion

      Volume: 84 Pages: 114-8

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Role of Th-2 cytokines in the development of Barrett's esophagus in rats.2011

    • Author(s)
      Kohata Y, Fujiwara Y, Machida H, Okazaki H, Yamagami H, Tanigawa T, Watanabe K, Watanabe T, Tominaga K, Wei M, Wanibuchi H, Arakawa T.
    • Journal Title

      J Gastroenterol.

      Volume: 46 Pages: 883-93

    • NAID

      10029313176

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] 多チャンネル食道インピーダンス-pHモニタリングを用いたPPI抵抗性NERDの分類とbaseline impedanceの関連2013

    • Author(s)
      木幡幸恵、藤原靖弘、荒川哲男
    • Organizer
      第99回日本消化器病学会総会
    • Place of Presentation
      鹿児島
    • Year and Date
      2013-03-23
    • Related Report
      2013 Final Research Report
  • [Presentation] 酸逆流が関連する好酸球性食道炎の臨床的基礎的研究2012

    • Author(s)
      藤原靖弘、須川貴史、荒川哲男
    • Organizer
      第98回日本消化器病学会総会
    • Place of Presentation
      東京
    • Year and Date
      2012-04-20
    • Related Report
      2013 Final Research Report
  • [Presentation] Klotho, an Aging Suppressor, and Fibroblast Growth Factor 23 is Involved in Gastric Ulcer Healing2012

    • Author(s)
      Tanigwa T, Watanabe T, Nadatani Y, Otani K, Machida H, Okazaki H, Yamagami H, Watanabe K, Tominaga K, Fujiwara Y, Arakawa T.
    • Organizer
      AGA
    • Place of Presentation
      アメリカ合衆国カリフォルニア州サンディエゴ、San Diego Convention Center
    • Related Report
      2012 Research-status Report
  • [Presentation] High-Mobility Group Box1 Promotes Small Intestinal Damage Induced by Non-Steroidal Antiinflammatory Drugs Through Toll-Like Receptor 42011

    • Author(s)
      Nadatani Y, Watanabe T, Tanigawa T, Otani K, MAchida H, Okazaki H, Yamagami H, Watanabe K, Tominaga K, Fujiwara Y, Arakawa T.
    • Organizer
      米国消化器病学会
    • Place of Presentation
      シカゴ
    • Related Report
      2011 Research-status Report
  • [Presentation] Toll-Like Receptor 9 Signaling Has Anti-Inflammatory Effects on the Early Phase of Helicobacter pylori-Induced Gastritis2011

    • Author(s)
      Otani K, Watanabe T, Tanigawa T, Nadatani Y, Machida H, Okazaki H, Yamagami H, Watanabe K, Tominaga K, Fujiwara Y, Arakawa T.
    • Organizer
      米国消化器病学会
    • Place of Presentation
      シカゴ
    • Related Report
      2011 Research-status Report
  • [Book] カラー版消化器病学基礎と臨床機能性ディスペプシア2013

    • Author(s)
      藤川佳子、富永和作、荒川哲男
    • Total Pages
      1541
    • Publisher
      西村書店
    • Related Report
      2013 Final Research Report
  • [Book] 新しい診断と治療のABC77:機能性食道疾患―GERDと機能性食道障害2013

    • Author(s)
      藤原靖弘、谷川徹也、山上博一、斯波将次、渡辺憲治、富永和作、渡辺俊雄、荒川哲男
    • Total Pages
      215
    • Publisher
      最新医学社
    • Related Report
      2013 Final Research Report
  • [Book] 今日の治療指針急性胃炎・急性胃潰瘍2012

    • Author(s)
      荒川哲男
    • Total Pages
      2064
    • Publisher
      医学書院
    • Related Report
      2013 Final Research Report
  • [Remarks]

    • URL

      http://www.med.osaka-cu.ac.jp/syoukaki/

    • Related Report
      2013 Final Research Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

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