Association between Helicobacter pylori infection and bronchial asthma

• Project/Area Number: 23590924
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Osaka City University
• Principal Investigator: ARAKAWA Tetsuo 大阪市立大学, 医学(系)研究科(研究院), 教授 (60145779)
• Co-Investigator(Kenkyū-buntansha): FUJIWARA Yasuhiro 大阪市立大学, 大学院医学研究科, 准教授 (40285292) ; TOMINAGA Kazunari 大阪市立大学, 大学院医学研究科, 准教授 (80336768) ; WATANABE Toshio 大阪市立大学, 大学院医学研究科, 准教授 (50336773) ; TANIGAWA Tetsuya 大阪市立大学, 大学院医学研究科, 講師 (70423879)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: ヘリコバクター・ピロリ / 気管支喘息 / 喘息 / ヘリコバクター / ヘリコバクターピロリ

Research Abstract

Helicobacter pylori infection is pathogens associated with gastritis, peptic ulcers, and gastric cancer. However, epidemiological studies showed a negative association between H. pylori infection and development of bronchial asthma. The aim of the present project was to determine whether H. pylori infection affects development of bronchial asthma in an animal model. We examined effect of H. pylori infection on severity of ovalbumin- induced asthma in Mongolian gerbil. Ovalbumin induced similar severity of asthma, infiltration of inflammatory cells, cytokines, histological changes in both H. pylori infected and non-infected mice. H. pylori infection might not be associated with development of bronchial asthma.

Research Products

• [Journal Article] Anti-tumour necrosis factor agents reduce non-steroidal anti-inflammatory drug-induced small bowel injury in rheumatoid arthritis patients. (2014)
  • Author(s): Watanabe T, Tanigawa T, Shiba M, Nadatani Y, Nagami Y, Sugimori S, Yamagami H, Watanabe K, Tominaga K, Fujiwara Y, Koike T, Arakawa T.
  • Journal Title: Gut Volume: 63 Issue: 3 Pages: 409-414
  • DOI: 10.1136/gutjnl-2013-304713
  • Peer Reviewed
• [Journal Article] Role of small intestinal bacterial overgrowth in severe small intestinal damage in chronic non-steroidal anti-inflammatory drug users. (2014)
  • Author(s): Muraki M, Fujiwara Y, Machida H, Okazaki H, Sogawa M, Yamagami H, Tanigawa T, Shiba M, Watanabe K, Tominaga K, Watanabe T, Arakawa T.
  • Journal Title: Scand J Gastroenterol Volume: 49 Pages: 267-273
  • Peer Reviewed
• [Journal Article] Infliximab and/or immunomodulators inhibit immune responses to trivalent influenza vaccination in adults with inflammatory bowel disease. (2014)
  • Author(s): Hagihara Y, Ohfuji S, Watanabe K, Yamagami H, Fukushima W, Maeda K, Kamata N, Sogawa M, Shiba M, Tanigawa T, Tominaga K, Watanabe T, Fujiwara Y, Hirota Y, Arakawa
  • Journal Title: J Crohns Colitis. Volume: 8 Issue: 3 Pages: 223-233
  • DOI: 10.1016/j.crohns.2013.08.008
  • Peer Reviewed
• [Journal Article] Rebamipide inhibits indomethacin-induced small intestinal injury : possible involvement of intestinal microbiota modulation by upregulation ofα-defensin 5 (2013)
  • Author(s): Tanigawa T, Watanabe T, Otani K, Nadatani Y, Ohkawa F, Sogawa M, Yamagami H, Shiba M, Watanabe K, Tominaga K, Fujiwara Y, Takeuchi K, Arakawa T
  • Journal Title: Eur J Pharmacol Volume: 704 Issue: 1-3 Pages: 64-9
  • DOI: 10.1016/j.ejphar.2013.02.010
  • Peer Reviewed
• [Journal Article] High-mobility group box 1 inhibits gastric ulcer healing through Toll-like receptor 4 and receptor for advanced glycation end products. (2013)
  • Author(s): Nadatani Y, Watanabe T, Tanigawa T, Ohkawa F, Takeda S, Higashimori A, Sogawa M, Yamagami H, Shiba M, Watanabe K, Tominaga K, Fujiwara Y, Takeuchi K, Arakawa T.
  • Journal Title: PLoS One Volume: 8 Issue: 11 Pages: e80130-e80130
  • DOI: 10.1371/journal.pone.0080130
  • Peer Reviewed
• [Journal Article] Mesenchymal stem cells administered in the early phase of tumorigenesis inhibit colorectal tumor development in rats (2013)
  • Author(s): Katsuno T, Ochi M, Tominaga K, Tanaka F, Sogawa M, Tanigawa T, Yamagami H, Shiba M, Watanabe K, Watanabe T, Fujiwara Y, Arakawa T.
  • Journal Title: Journal of Clinical Biochemistry and Nutrition Volume: 53 Issue: 3 Pages: 170-175
  • DOI: 10.3164/jcbn.13-68
  • NAID: 130004466728
  • ISSN: 0912-0009, 1880-5086
  • Peer Reviewed
• [Journal Article] A multicenter study on the prevalence of Eosinophilic Esophagitis and PPI-responsive esophageal eosinophilic infiltration (2012)
  • Author(s): Fujiwara Y, Sugawa T, Tanaka F, Tatsuwaki H, Okuyama M, Hayakawa T, Yamamori K, Wada R, Ohtani K, Uno H, Tanigawa T, Watanabe Y, Tominaga K, Watanabe T, Takaishi O, Saeki Y, Nebiki H, Oshitani N, Sato H, Arakawa T
  • Journal Title: Intern Med Volume: 51 Pages: 3235-9
  • NAID: 130003308153
  • Peer Reviewed
• [Journal Article] Toll-like receptor 9 signaling has anti-inflammatory effects on the early phase of Helicobacter pylori-induced gastritis. (2012)
  • Author(s): Otani K, Tanigawa T, Watanabe T, Nadatani Y, Sogawa M, Yamagami H, Shiba M, Watanabe K, Tominaga K, Fujiwara Y, Arakawa T.
  • Journal Title: Biochem Biophys Res Commun. Volume: 426 Issue: 3 Pages: 342-9
  • DOI: 10.1016/j.bbrc.2012.08.080
  • Peer Reviewed
• [Journal Article] Activation of the MyD88 signaling pathway inhibits ischemia-reperfusion injury in the small intestine (2012)
  • Author(s): Watanabe T, Kobata A, Tanigawa T, Nadatani Y, Yamagami H, Watanabe K, Tominaga K, Fujiwara Y, Takeuchi K, Arakawa T
  • Journal Title: Am J Physiol Gastrointest Liver Physiol Volume: 303 Issue: 3 Pages: G324-G334
  • DOI: 10.1152/ajpgi.00075.2012
  • Peer Reviewed
• [Journal Article] High mobility group box 1 promotes small intestinal damage induced by nonsteroidal anti-inflammatory drugs through Toll-like receptor 4. (2012)
  • Author(s): Nadatani Y, Watanabe T, Tanigawa T, Machida H, Okazaki H, Yamagami H, Watanabe K, Tominaga K, Fujiwara Y, Arakawa T
  • Journal Title: Am J Pathol. Volume: 181 Issue: 1 Pages: 98-110
  • DOI: 10.1016/j.ajpath.2012.03.039
  • Peer Reviewed
• [Journal Article] Small intestinal injury caused by NSAIDs/aspirin : finding new from old (2012)
  • Author(s): Arakawa T, Watanabe T, Tanigawa T, Tominaga K, Otani K, Nadatani Y, Fujiwara Y
  • Journal Title: Curr Med Chem Volume: 19 Issue: 1 Pages: 77-81
  • DOI: 10.2174/092986712803414105
  • Peer Reviewed
• [Journal Article] Activation of the MyD88 signaling pathway inhibits ischemia-reperfusion injury in the small intestine. (2012)
  • Author(s): Watanabe T, Kobata A, Tanigawa T, Nadatani Y, Yamagami H, Watanabe K, Tominaga K, Fujiwara Y, Takeuchi K, Arakawa T
  • Journal Title: Am J Physiol Gastrointest Liver Physiol. Volume: 303
  • Peer Reviewed
• [Journal Article] Small intestinal injury caused by NSAIDs/aspirin: finding new from old. (2012)
  • Author(s): Arakawa T, Watanabe T, Tanigawa T, Tominaga K, Otani K, Nadatani Y, Fujiwara Y.
  • Journal Title: Curr Med Chem. Volume: 19 Pages: 77-81
  • Peer Reviewed
• [Journal Article] Role of Th-2 cytokines in the development of Barrett's esophagus in rats (2011)
  • Author(s): Kohata Y, Fujiwara Y, Machida H, Okazaki H, Yamagami H, Tanigawa T, Watanabe K, Watanabe T, Tominaga K, Wei M, Wanibuchi H, Arakawa T
  • Journal Title: J Gastroenterol Volume: 46 Issue: 7 Pages: 883-93
  • DOI: 10.1007/s00535-011-0405-y
  • NAID: 10029313176
  • Peer Reviewed
• [Journal Article] Dysregulated upregulation of T-cell immunoglobulin and mucin domain-3 on mucosal T helper 1 cells in patients with Crohn's disease (2011)
  • Author(s): Morimoto K, Hosomi S, Yamagami H, Watanabe K, Kamata N, Sogawa M, Machida H, Okazaki H, Tanigawa T, Nagahara H, Noda E, Tominaga K, Watanabe T, Fujiwara Y, Maeda K, Hirakawa K, Arakawa T
  • Journal Title: Scand J Gastroenterol Volume: 46 Issue: 6 Pages: 701-9
  • DOI: 10.3109/00365521.2011.568518
  • Peer Reviewed
• [Journal Article] Dysregulated upregulation of T-cell immunoglobulin and mucin domain-3 on mucosal T helper 1 cells in patients with Crohn's disease. (2011)
  • Author(s): Morimoto K, Hosomi S, Yamagami H, Watanabe K, Kamata N, Sogawa M, Machida H, Okazaki H, Tanigawa T, Nagahara H, Noda E, Tominaga K, Watanabe T, Fujiwara Y, Maeda K, Hirakawa K, Arakawa T.
  • Journal Title: Scand J Gastroenterol Volume: 46 Pages: 701-9
  • Peer Reviewed
• [Journal Article] Association between left-handedness and gastrointestinal symptoms. (2011)
  • Author(s): Fujiwara Y, Kubo M, Kohata Y, Yamagami H, Tanigawa T, Watanabe K, Watanabe T, Tominaga K, Arakawa T.
  • Journal Title: Digestion Volume: 84 Pages: 114-8
  • Peer Reviewed
• [Journal Article] Role of Th-2 cytokines in the development of Barrett's esophagus in rats. (2011)
  • Author(s): Kohata Y, Fujiwara Y, Machida H, Okazaki H, Yamagami H, Tanigawa T, Watanabe K, Watanabe T, Tominaga K, Wei M, Wanibuchi H, Arakawa T.
  • Journal Title: J Gastroenterol. Volume: 46 Pages: 883-93
  • NAID: 10029313176
  • Peer Reviewed
• [Presentation] 多チャンネル食道インピーダンス-pHモニタリングを用いたPPI抵抗性NERDの分類とbaseline impedanceの関連 (2013)
  • Author(s): 木幡幸恵、藤原靖弘、荒川哲男
  • Organizer: 第99回日本消化器病学会総会
  • Place of Presentation: 鹿児島
  • Year and Date: 2013-03-23
• [Presentation] 酸逆流が関連する好酸球性食道炎の臨床的基礎的研究 (2012)
  • Author(s): 藤原靖弘、須川貴史、荒川哲男
  • Organizer: 第98回日本消化器病学会総会
  • Place of Presentation: 東京
  • Year and Date: 2012-04-20
• [Presentation] Klotho, an Aging Suppressor, and Fibroblast Growth Factor 23 is Involved in Gastric Ulcer Healing (2012)
  • Author(s): Tanigwa T, Watanabe T, Nadatani Y, Otani K, Machida H, Okazaki H, Yamagami H, Watanabe K, Tominaga K, Fujiwara Y, Arakawa T.
  • Organizer: AGA
  • Place of Presentation: アメリカ合衆国カリフォルニア州サンディエゴ、San Diego Convention Center
• [Presentation] High-Mobility Group Box1 Promotes Small Intestinal Damage Induced by Non-Steroidal Antiinflammatory Drugs Through Toll-Like Receptor 4 (2011)
  • Author(s): Nadatani Y, Watanabe T, Tanigawa T, Otani K, MAchida H, Okazaki H, Yamagami H, Watanabe K, Tominaga K, Fujiwara Y, Arakawa T.
  • Organizer: 米国消化器病学会
  • Place of Presentation: シカゴ
• [Presentation] Toll-Like Receptor 9 Signaling Has Anti-Inflammatory Effects on the Early Phase of Helicobacter pylori-Induced Gastritis (2011)
  • Author(s): Otani K, Watanabe T, Tanigawa T, Nadatani Y, Machida H, Okazaki H, Yamagami H, Watanabe K, Tominaga K, Fujiwara Y, Arakawa T.
  • Organizer: 米国消化器病学会
  • Place of Presentation: シカゴ
• [Book] カラー版消化器病学基礎と臨床機能性ディスペプシア (2013)
  • Author(s): 藤川佳子、富永和作、荒川哲男
  • Total Pages: 1541
  • Publisher: 西村書店
• [Book] 新しい診断と治療のABC77:機能性食道疾患―GERDと機能性食道障害 (2013)
  • Author(s): 藤原靖弘、谷川徹也、山上博一、斯波将次、渡辺憲治、富永和作、渡辺俊雄、荒川哲男
  • Total Pages: 215
  • Publisher: 最新医学社
• [Book] 今日の治療指針急性胃炎・急性胃潰瘍 (2012)
  • Author(s): 荒川哲男
  • Total Pages: 2064
  • Publisher: 医学書院
• [Remarks]
  • URL: http://www.med.osaka-cu.ac.jp/syoukaki/