| Project/Area Number |
23590924
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Osaka City University |
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Principal Investigator |
ARAKAWA Tetsuo 大阪市立大学, 医学(系)研究科(研究院), 教授 (60145779)
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| Co-Investigator(Kenkyū-buntansha) |
FUJIWARA Yasuhiro 大阪市立大学, 大学院医学研究科, 准教授 (40285292)
TOMINAGA Kazunari 大阪市立大学, 大学院医学研究科, 准教授 (80336768)
WATANABE Toshio 大阪市立大学, 大学院医学研究科, 准教授 (50336773)
TANIGAWA Tetsuya 大阪市立大学, 大学院医学研究科, 講師 (70423879)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | ヘリコバクター・ピロリ / 気管支喘息 / 喘息 / ヘリコバクター / ヘリコバクターピロリ |
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| Research Abstract |
Helicobacter pylori infection is pathogens associated with gastritis, peptic ulcers, and gastric cancer. However, epidemiological studies showed a negative association between H. pylori infection and development of bronchial asthma. The aim of the present project was to determine whether H. pylori infection affects development of bronchial asthma in an animal model. We examined effect of H. pylori infection on severity of ovalbumin- induced asthma in Mongolian gerbil. Ovalbumin induced similar severity of asthma, infiltration of inflammatory cells, cytokines, histological changes in both H. pylori infected and non-infected mice. H. pylori infection might not be associated with development of bronchial asthma.
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