| Project/Area Number |
23590925
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Osaka City University |
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Principal Investigator |
TANIGAWA Tetsuya 大阪市立大学, 医学(系)研究科(研究院), 講師 (70423879)
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| Co-Investigator(Kenkyū-buntansha) |
WATANABE Toshio 大阪市立大学, 大学院医学研究科, 准教授 (50336773)
TOMINAGA Kazunari 大阪市立大学, 大学院医学研究科, 准教授 (80336768)
FUJIWARA Yasuhiro 大阪市立大学, 大学院医学研究科, 准教授 (40285292)
MACHIDA Hirohisa 大阪市立大学, 大学院医学研究科, 医員 (00382078)
ARAKAWA Tetsuo 大阪市立大学, 大学院医学研究科, 教授 (60145779)
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| Research Collaborator |
OTANI Koji 大阪市立大学, 大学院医学研究科, 研究医
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
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| Keywords | Klotho / ヘリコバクター・ピロリ / 萎縮性胃炎 / 胃潰瘍 / TLR9 / 胃発がん / 炎症 / 老化 / Helicobacter pylori / 胃癌 / 細胞増殖 / 創傷治癒 / 消化管上皮 / 慢性胃炎 / klotho |
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| Research Abstract |
The klotho gene was originally identified as an aging suppressor gene. We investigated whether Klotho is involved in pathophysiology in the stomach diseases. (Study 1) Gastric ulcer is associated with Helicobacter pylori (Hp) infection. During gastric ulcer healing, expression of mRNA for Klotho in gastric epithelial cells at the ulcer margin was reduced compared with normal gastric tissue. Administration of recombinant Klotho accelerated gastric ulcer healing. (Study 2) We investigated the expression and role of TLR9 in H. pylori-induced gastritis in mice. Our findings suggest that TLR9 signaling plays important roles in the suppression of H. pylori-induced gastric mucosal inflammation in the early phase via downregulation of TNF-alpha modulated by IFN-alpha1. (Study 3) Expression of mRNA for Klotho was downregulated in Hp-infected mice compared uninfected mice, suggesting the promotion of atrophy and carcinogenesis of the stomach .
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