| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Research Abstract |
We investigated to see how single nucleotide polymorphism (SNP) of cyclooxygenase(COX)-2 and IL-1 beta genes is involved in the progression of Helicobacter pylori(Hp) gastritis to strophic gastritis, comparing SNP (COX-2SNP rs689466, IL-1 betaSNP rs16944) and atrophic scores determined by histrolgy. Activity, inflammation, atrophy and intestinal metaplasma in Hp-gastritis mucosa were histologideally scored as 0-3 according to Updated Sydney system. 1L-1betaSNP-511T/T was shown to be correlated with the progression of strophic gastritis as previously reported. However, COX-2 gene SNP -1195 was not found to be correlated with strophic gastritis in the present study.
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