Protective role of Reg protein on mucosal injury in the gastrointestinal tract

• Project/Area Number: 23590929
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Hyogo Medical University
• Principal Investigator: FUKUI Hirokazu 兵庫医科大学, 医学部, 講師 (60378742)
• Co-Investigator(Kenkyū-buntansha): MIWA Hiroto 兵庫医科大学, 医学部, 教授 (80190833) ; WATARI Jiro 兵庫医科大学, 医学部, 教授 (10311531) ; OSHIMA Tadayuki 兵庫医科大学, 医学部, 講師 (00381814)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2011: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
• Keywords: 遺伝子 / 再生医学 / 臨床 / 感染 / 癌

Research Abstract

Reg protein may function as an antimicrobial peptide and its expression is significantly regulated by IL-22 stimulation. Furthermore, Reg protein functions a trophic and/or anti-apoptotic factor on not only epithelial but also endothelial cells in the gastrointestinal mucosa. These effects are advantageous to protect the gastrointestinal mucosal injury. However, in gastric cancer tissues the anti-apoptotic effect of dysregulated Reg protein may confer resistance to chemotherapeutic drugs in gastric cancer cells.

Research Products

• [Journal Article] REG Iαis a biomarker for predicting response to chemotherapy with S-1 puls cisplatin in patients with unresectable stage IV gastric cancer (2013)
  • Author(s): Sekikawa A, Fukui H, Zhang X, Maruo T, Tsumura T, Okabe Y, Wakasa T, Osaki Y, Chiba T, Tomita T, Oshima T, Watari J, Miwa H
  • Journal Title: Br J Cancer Volume: 108 Pages: 395-401
  • Peer Reviewed
• [Journal Article] Acidic deoxycholic acid and chenodeoxycholic acid induce IL-8 production through p38 MAPK and PKA in a squamous epithelial model (2013)
  • Author(s): Shan J, Oshima T, Fukui H, Watari J, Miwa
  • Journal Title: J Gastroenterol Hepatol Volume: 28 Pages: 823-828
  • Peer Reviewed
• [Journal Article] Down-regulation of claudin-18 is associated with the proliferative and invasive potential of gastric cancer at the invasive front (2013)
  • Author(s): Oshima T, Shan J, Okugawa T, Chen X, Hori K, Tomita T, Fukui H, Watari J, Miwa H
  • Journal Title: PLoS One Volume: 8
  • Peer Reviewed
• [Journal Article] Overexpression of regenerating gene Iαappears to reflect aberration of crypt cell compartmentalization in sessile serrated adenoma/polyps of the colon (2013)
  • Author(s): Okamoto K, Fujimori T, Yamaguchi T, Ichikawa K, Tomita S, Imura J, Ohkura Y, Yao T, Fujii S, Kusaka T, Sekikawa A, Fukui H, Chiba T, Kato H, Mitomi H
  • Journal Title: Diagn Pathol Volume: 8 Pages: 187-187
  • Peer Reviewed
• [Journal Article] Overexpression of regenerating gene Iα appears to reflect aberration of crypt cell compartmentalization in sessile serrated adenoma/polyp of the colon (2013)
  • Author(s): Okamoto K, Fujimori T (16人中2番目)
  • Journal Title: Diagnostic Pathology Volume: 8 Issue: 1 Pages: 187-187
  • DOI: 10.1186/1746-1596-8-187
  • Peer Reviewed
• [Journal Article] REG Iα is a biomarker for predicting response to chemotherapy S-1 plus cisplatin in patients with unresectab le stage IV gastric cancer. (2013)
  • Author(s): Sekikawa A, Fukui H, Zhang X, Maruo T, Tsumura T, Okabe Y, Wakasa T, Osaki Y, Chiba T, Tomita T, Oshima T, Watari J, Miwa H.
  • Journal Title: Br J Cancer. Volume: 108(2) Issue: 2 Pages: 395-401
  • DOI: 10.1038/bjc.2012.572
  • Peer Reviewed / Open Access
• [Journal Article] Regenerating gene (REG) 1 alpha promotes pannus progression in patients with rheumatoid arthritis (2012)
  • Author(s): Fujishiro M, Nozawa K, Kawasaki M, Yamaguchi A, Iwabuchi K, Yanagida M, Suzuki F, Miyazawa K, Fukui H, Kaneko K, Ogawa H, Takamori K, Takasaki Y, Sekigawa I
  • Journal Title: Mod Rheumatol Volume: 22 Pages: 228-237
  • NAID: 10030615061
  • Peer Reviewed
• [Journal Article] Down-regulation of claudin-3 is associated with proliferative potential in early gastric cancers (2012)
  • Author(s): Okugawa T, Oshima T, Chen X, Hori K, Tomita T, Fukui H, Watari J, Miwa H
  • Journal Title: Dig Dis Sci Volume: 57 Pages: 1562-1567
  • Peer Reviewed
• [Journal Article] Bile salts disrupt human esophageal squamous epithelial barrier function by modulating tight junction proteins (2012)
  • Author(s): Chen X, Oshima T, Shan J, Fukui H, Watari J, Miwa H
  • Journal Title: Am J Physiol Volume: 303
  • Peer Reviewed
• [Journal Article] Trypsin impaired epithelial barrier function and induced IL-8 secretion through basolateral PAR-2: a lesson from a stratified squamous epithelial model (2012)
  • Author(s): Shan J, Oshima T, Chen X, Fukui H, Watari J, Miwa H
  • Journal Title: Am J Physiol Volume: 303
  • Peer Reviewed
• [Journal Article] Regenerating gene (REG) I alpha promotes pannus progression in patients with rheumatoid arthritis (2012)
  • Author(s): Fujishiro M
  • Journal Title: Mod Rheumatol Volume: 22 Issue: 2 Pages: 228-237
  • DOI: 10.1007/s10165-011-0564-y
  • Peer Reviewed
• [Journal Article] DMBT1 is a novel gene induced by IL-22 in ulcerative colitis (2011)
  • Author(s): Fukui H, Sekikawa A, Tanaka H, Fujimori Y, Katake Y, Fujii S, Ichikawa K, Tomita S, Imura J, Chiba T, Fujimori T
  • Journal Title: Inflam Bowel Dis Volume: 17 Pages: 1177-1188
  • Peer Reviewed
• [Journal Article] Acidic bile salts modulate the squamous epithelial barrier function by modulating tight junction proteins (2011)
  • Author(s): Chen X, Oshima T, Tomita T, Fukui H, Watari J, Matsumoto T, Miwa H
  • Journal Title: Am J Physiol Volume: 301
  • Peer Reviewed
• [Journal Article] Immunohistochemical analysis of REG Iα expression in ulcerative colitis-associated neoplastic lesions (2011)
  • Author(s): Tanaka H, Fukui H, Fujii S, Sekikawa A, Yamagishi H, Ichikawa K, Tomita S, Itnura J, Yasuda Y, Chiba T, Fujimori T
  • Journal Title: Digestion Volume: 83 Issue: 3 Pages: 204-209
  • DOI: 10.1159/000321808
  • Peer Reviewed
• [Presentation] 胃炎―胃癌相関におけるSTAT3シグナル活性の意義について (2014)
  • Author(s): 福井広一
  • Organizer: 第100回日本消化器病学会総会
  • Place of Presentation: 東京
  • Year and Date: 2014-04-24
• [Presentation] NSAID起因性消化管粘膜傷害におけるReg遺伝子の発現意義について (2013)
  • Author(s): 福井広一
  • Organizer: 第41回日本潰瘍学会
  • Place of Presentation: 吹田市
  • Year and Date: 2013-12-07
• [Presentation] Expression of Reg family genes in the gastrointestinal tract injured by indomethacin (2013)
  • Author(s): Sun C, Fukui H
  • Organizer: The Asian Pacific Digestive Week/World Congress of Gastroenterology
  • Place of Presentation: Shanghai, China
  • Year and Date: 2013-09-23
• [Presentation] GROαpromotes invasion of gastric cancer cells (2013)
  • Author(s): Fukui H
  • Organizer: Digestive Disease Week 2013
  • Place of Presentation: Orland, USA
  • Year and Date: 2013-05-18
• [Presentation] REG Iαplays a role in resistance to chemotherapy in gastric cancer (2012)
  • Author(s): Fukui H
  • Organizer: United European Gastroenterology Week
  • Place of Presentation: Amsterdam, Netherland
  • Year and Date: 2012-10-23
• [Presentation] 腸上皮化生と胃癌組織におけるREG蛋白発現の意義について (2012)
  • Author(s): 福井広一
  • Organizer: 第54回日本消化器病学会大会
  • Place of Presentation: 神戸
  • Year and Date: 2012-10-11
• [Presentation] Involvement of IL-22 signaling in gastric cancer cell invasion (2012)
  • Author(s): Fukui H
  • Organizer: Digestive Disease Week 2012
  • Place of Presentation: San Diego, USA
  • Year and Date: 2012-05-20
• [Presentation] 胃癌細胞の浸潤におけるインターロイキン22の役割について (2012)
  • Author(s): 福井広一
  • Organizer: 第98回日本消化器病学会総会
  • Place of Presentation: 東京
  • Year and Date: 2012-04-20
• [Presentation] 胃炎発癌におけるSTAT3/REGシグナルの役割 (2011)
  • Author(s): 福井広一
  • Organizer: 第53回日本消化器病学会大会
  • Place of Presentation: 福岡
  • Year and Date: 2011-10-21
• [Presentation] Involvement of IL-22/STAT3 signaling in the expression of antimicrobial molecules in gastrointestinal epithelial cells (2011)
  • Author(s): Fukui H
  • Organizer: Digestive Disease Week 2011
  • Place of Presentation: Chicago, USA
  • Year and Date: 2011-05-15
• [Presentation] 胃癌治療におけるREG蛋白の標的分子としての可能性について (2011)
  • Author(s): 福井広一
  • Organizer: 第97回日本消化器病学会総会
  • Place of Presentation: 東京
  • Year and Date: 2011-05-15
• [Presentation] 胃癌治療における REG 蛋白の標的分子としての可能性について (2011)
  • Author(s): 福井広一
  • Organizer: 第 97 回日本消化器病学会総会
  • Place of Presentation: 東京
• [Presentation] Involvement of IL-22/STAT3 Signaling in the Expression of Antimicrobial Molecules in Gastrointestinal Epithelial Cells (2011)
  • Author(s): Fukui H
  • Organizer: Digestive Disease Week 2011
  • Place of Presentation: Chicago, USA
• [Presentation] 胃炎発癌における STAT3/REG シグナルの役割 (2011)
  • Author(s): 福井広一
  • Organizer: 第 53 回日本消化器病学会大会
  • Place of Presentation: 福岡
• [Presentation] GROa promotes invasion of gastric cancer cells
  • Author(s): Fukui H
  • Organizer: Digestive Disease Week 2013
  • Place of Presentation: Orland, USA
• [Presentation] Expression of Reg family genes in the gastrointestinal tract injured by indomethacin
  • Author(s): Sun C, Fukui H, Shan Jin, Toshihiko Tomita, Tadayuki Oahima, Jiro Watari, Miwa H.
  • Organizer: The Asian Pacific Digestive Week/World Congress of Gastroenterology
  • Place of Presentation: Shanghai, China
• [Presentation] NSAID 起因性消化管粘膜傷害における Reg 遺伝子の発現意義について
  • Author(s): 福井広一
  • Organizer: 第 41 回日本潰瘍学会
  • Place of Presentation: 吹田市
• [Presentation] 胃炎―胃癌相関におけるSTAT3シグナル活性の意義につい
  • Author(s): 福井広一
  • Organizer: 第 100 回日本消化器病学会総会
  • Place of Presentation: 東京都千代田区
• [Presentation] 胃癌細胞の浸潤におけるインターロイキン 22 の役割について
  • Author(s): 福井広一
  • Organizer: 第98回日本消化器病学会総会
  • Place of Presentation: 東京
• [Presentation] 腸上皮化生と胃癌組織における REG 蛋白発現の意義について
  • Author(s): 福井広一
  • Organizer: 第54回日本消化器病学会大会
  • Place of Presentation: 神戸
• [Presentation] REG Ia plays a role in resistance to chemotherapy in gastric cancer
  • Author(s): Fukui H
  • Organizer: United European Gastroenterology Week
  • Place of Presentation: Amsterdam, Netherland