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Associated factors for low dose aspirin induced gastrointestinal mucosal injury

Research Project

Project/Area Number 23590930
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Gastroenterology
Research InstitutionKawasaki Medical School

Principal Investigator

SHIOTANI Akiko  川崎医科大学, 医学部, 准教授 (80275354)

Co-Investigator(Kenkyū-buntansha) NISHIO Kazuto  近畿大学, 医学部 ゲノム生物学, 教授 (10208134)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords低用量アスピリン / 小腸粘膜傷害 / 網羅的SNP解析 / CYP2D6 / CYP4F11 / アスピリン小腸出血 / 網羅的遺伝子解析 / DMET plus / 小腸出血 / 網羅的遺伝子多型解析
Research Abstract

Genome-wide analysis of single nucleotide polymorphisms (SNPs) was performed using the Affymetrix DMET™ Plus Premier Pack. In the validation study in overall 37 patients with small bowel bleeding and 400 controls, 4 of 27 identified SNPs: CYP4F11 (rs1060463) GG (p=0.003), CYP2D6 (rs28360521) GG (p=0.02), CYP24A1 (rs4809957) T allele (p=0.04), and GSTP1 (rs1695) G allele (p=0.04) were significantly more frequent in the small bowel bleeding group compared to the controls. After adjustment for significant factors, CYP2D6 (rs28360521) GG (OR 4.11, 95% CI. 1.62 -10.4) was associated with small bowel bleeding. CYP4F11 and CYP2D6 SNPs may identify patients at increased risk for aspirin-induced small bowel bleeding.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (29 results)

All 2014 2013 2012 2011 Other

All Journal Article (12 results) (of which Peer Reviewed: 11 results) Presentation (14 results) (of which Invited: 3 results) Remarks (1 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] Novel single nucleotide polymorphism markers for low dose aspirin-associated small bowel bleeding2013

    • Author(s)
      Shiotani A, Murao T, Fujita Y, Sakakibara T, Nishio K, Haruma K
    • Journal Title

      PLoS One

      Volume: 18;8(12)

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Novel single nucleotide polymorphism markers for low dose aspirin-associated small bowel bleeding2013

    • Author(s)
      Shiotani A, Murao T, Fujita Y, Fujimura Y, Sakakibara T, Nishio K, Haruma K
    • Journal Title

      PLoS One

      Volume: 8

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association of SLCO1B1 1b with peptic ulcer amongst Japanese patients taking low-dose aspirin2012

    • Author(s)
      Shiotani A, Murao T, Sakakibara T, et al.(他5名)
    • Journal Title

      Dig Liver Dis

      Volume: 44 Pages: 201-205

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Risk and preventive factors of low-dose aspirin-induced gastroduodenal injuries : a comprehensive review2012

    • Author(s)
      Shiotani A, Manabe N, Kamada T, et al.(他3名)
    • Journal Title

      J Gastroenterol Hepatol

      Volume: 27 Suppl 3 Pages: 8-12

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Risk and preventive factors of low-dose aspirin-induced gastroduodenal injuries: a comprehensive review.2012

    • Author(s)
      Shiotani A, Manabe N, Kamada T, et al.
    • Journal Title

      J Gastroenterol Hepatol

      Volume: 27 Suppl 3 Pages: 8-12

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Association of SLCO1B1 1b with peptic ulcer amongst Japanese patients taking low-dose aspirin.2012

    • Author(s)
      Shiotani A, Murao T, Sakakibara T, et al.
    • Journal Title

      Dig Liver Dis

      Volume: 44(3) Issue: 3 Pages: 201-5

    • DOI

      10.1016/j.dld.2011.10.005

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] 当院における小腸カプセル内視鏡検査の5年間の集計2012

    • Author(s)
      塩谷昭子
    • Journal Title

      川崎医学会誌

      Volume: 38(3) Pages: 97-105

    • NAID

      110009486745

    • Related Report
      2012 Research-status Report
  • [Journal Article] Association of SLCO1B1 1b with peptic ulcer amongst Japanese patients taking low-dose aspirin.2012

    • Author(s)
      Shiotani Akiko
    • Journal Title

      Dig Liver Dis

      Volume: 44 Pages: 201-5

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Risk and preventive factors of low-dose aspirin-induced gastroduodenal injuries: A comprehensive review.2012

    • Author(s)
      Shiotani Akiko
    • Journal Title

      J Gastroenterol Hepatol

      Volume: 27 Suppl3 Pages: 8-12

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Renin-angiotensin system associated with risk of upper GI mucosal injury induced by low dose aspirin : renin angiotensin system genes' polymorphism2011

    • Author(s)
      Shiotani A, Nishi R, Yamanaka Y, et al.(他7名)
    • Journal Title

      Dig Dis Sci

      Volume: 56 Pages: 465-471

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Combination of low-dose aspirin and thienopyridine exacerbates small bowel injury2011

    • Author(s)
      Shiotani A, Honda K, Murao T, et al.(他7名)
    • Journal Title

      Scand J Gastroenterol

      Volume: 46 Pages: 281-286

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Combination of low-dose aspirin and thienopyridine exacerbates small bowel injury.2011

    • Author(s)
      Shiotani Akiko
    • Journal Title

      Scand J Gastroenterol

      Volume: 46 Pages: 281-6

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] Novel Single nucleotide polymorphism markers for low dose aspirin-associated small bowel bleeding : a DMET microarray profiling study2014

    • Author(s)
      Shiotani A, Murao T, Fujita Y, Fujimura Y, Sakakibara T, Nishio K, Haruma K
    • Organizer
      Digestive Disease Week 2014
    • Place of Presentation
      Chicago
    • Related Report
      2013 Final Research Report
  • [Presentation] 低用量腸溶剤アスピリン(LDA)による消化性潰瘍出血の実態とその対策2014

    • Author(s)
      塩谷昭子, 木村智成, 春間賢
    • Organizer
      第100回日本消化器病学会総会
    • Place of Presentation
      東京
    • Related Report
      2013 Final Research Report
  • [Presentation] 低用量アスピリン内服小腸出血患者における遺伝子多型の検討網羅的SNPs解析による検討2014

    • Author(s)
      塩谷昭子, 村尾高久, 木村智成, 藤村宜憲, 春間賢
    • Organizer
      第10回日本消化管学会総会学術集会
    • Place of Presentation
      福島
    • Related Report
      2013 Final Research Report
  • [Presentation] 低用量アスピリン内服小腸出血患者における遺伝子多型の検討網羅的SNPs解析による検討2014

    • Author(s)
      塩谷昭子, 村尾高久, 木村智成, 藤村宜憲, 春間賢
    • Organizer
      第10回日本消化管学会総会学術集会
    • Place of Presentation
      福島市(コラッセふくしま)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 低用量腸溶剤アスピリン(LDA)による消化性潰瘍出血の実態とその対策2014

    • Author(s)
      塩谷昭子、木村智成、春間 賢
    • Organizer
      第100回日本消化器病学会
    • Place of Presentation
      東京(東京国際フォーラム)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Novel Single nucleotide polymorphism markers for low dose aspirin-associated small bowel bleeding: a DMET microarray profiling study2014

    • Author(s)
      Akiko Shiotani, Takahisa Murao, Yoshihiko Fujita, Yoshinori Fujimura, Takashi Sakakibara, Kazuto Nishio, and Ken Haruma
    • Organizer
      DDW 2014
    • Place of Presentation
      米国シカゴ(McCormick Place)
    • Related Report
      2013 Annual Research Report
  • [Presentation] NSAIDs、LDAによる小腸粘膜傷害カプセル内視鏡を用いた低用量腸溶剤アスピリンおよびNSAIDsによる小腸粘膜病変に関する臨床的検討2012

    • Author(s)
      塩谷昭子, 本多啓介, 春間賢:
    • Organizer
      第83回日本消化器内視鏡学会総会
    • Place of Presentation
      東京
    • Related Report
      2013 Final Research Report
  • [Presentation] Slco1b1*1b haplotype is associated with risk of aspirin induced peptic ulcer and bleeding2011

    • Author(s)
      Shiotani A, Murao T , Tsutsui H , Imamura H, Tarumi K, Manabe N, Kamada T, Kusunoki H, Sakakibara T, Haruma K
    • Organizer
      Digestive Disease Week 2011
    • Place of Presentation
      Chicago
    • Related Report
      2013 Final Research Report
  • [Presentation] 抗血小板療法による消化管傷害低用量アスピリン上部消化管潰瘍病変と遺伝子多型からみた関連因子の検討2011

    • Author(s)
      塩谷昭子, 榊原敬, 春間賢
    • Organizer
      第97回日本消化器病学会総会
    • Place of Presentation
      東京
    • Related Report
      2013 Final Research Report
  • [Presentation] Slco1b1*1b haplotype is associated with risk of aspirin induced peptic ulcer and bleeding.2011

    • Author(s)
      Shiotani Akiko
    • Organizer
      Digestive Disease Week 2011
    • Place of Presentation
      Chicago
    • Related Report
      2011 Research-status Report
  • [Presentation] 多剤抗血小板・抗凝固療法と消化管出血対策

    • Author(s)
      塩谷昭子
    • Organizer
      第60回日本心臓病学会
    • Place of Presentation
      ホテル日航金沢(金沢市)
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] 抗血栓療法と消化管出血対策

    • Author(s)
      塩谷昭子
    • Organizer
      第26回日本消化器内視鏡学会近畿セミナー
    • Place of Presentation
      京都テルサ (京都市)
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] アスピリン小腸粘膜傷害の新たなる展開ーその危険因子を探るー

    • Author(s)
      塩谷昭子
    • Organizer
      第99回日本消化器病学会総会
    • Place of Presentation
      城山観光ホテル(鹿児島市)
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] 網羅的SNP解析による低用量アスピリン内服患者の小腸出血関連SNPsの検討

    • Author(s)
      村尾 高久、塩谷 昭子、春間 賢
    • Organizer
      第99回日本消化器病学会総会
    • Place of Presentation
      城山観光ホテル(鹿児島市)
    • Related Report
      2012 Research-status Report
  • [Remarks] 本研究のマイクロアレイの結果は、以下の データベースに登録 Gene Expression Omnibus (GEO) database

    • URL

      http://www.ncbi.nlm.nih.gov/geo/

    • Related Report
      2013 Final Research Report
  • [Patent(Industrial Property Rights)] 低用量腸溶剤アスピリンによる消化管 出血関連遺伝子多型の特定2013

    • Inventor(s)
      塩谷昭子
    • Industrial Property Rights Holder
      塩谷昭子
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2013-030473
    • Filing Date
      2013-02-19
    • Related Report
      2013 Final Research Report
  • [Patent(Industrial Property Rights)] 低用量腸溶剤アスピリンによる消化管出血関連遺伝子多型の特定2013

    • Inventor(s)
      塩谷昭子
    • Industrial Property Rights Holder
      塩谷昭子
    • Industrial Property Rights Type
      特許
    • Filing Date
      2013-02-19
    • Related Report
      2012 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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