Novel roles of transporters and adherent molecules of epithelial membrane in the recognition of bacteria
Project/Area Number |
23590931
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Gastroenterology
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Research Institution | Asahikawa Medical College |
Principal Investigator |
|
Co-Investigator(Kenkyū-buntansha) |
OHTAKE Takaaki 旭川医科大学, 医学部, 講師 (10359490)
|
Project Period (FY) |
2011 – 2013
|
Project Status |
Completed (Fiscal Year 2013)
|
Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
Keywords | 下部消化管学(小腸、大腸) / 腸内細菌 / 炎症性腸疾患 / ポリリン酸 / トランスポーター / エンドサイトーシス / インテグリン / 接着分子 |
Research Abstract |
Competence and sporulation factor and polyphosphate were identified as bioactive molecules from the conditioned media of Bacillus subtilis and Lactobacillus brevis SB88, respectively. These molecules improved the intestinal injury through their transport by OCTN2 and binding to integrin 1, respectively. The novel communication systems between the host and bacteria are distinct from the mechanisms mediated by pattern-recognition receptors, such as Toll-like receptors and NODs. These results are therefore expected to positively contribute to the development of new drugs for the treatment of intestinal inflammation using bacteria-derived molecules.
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Report
(4 results)
Research Products
(105 results)
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[Journal Article] Up-regulation of iron regulatory hormone hepcidin by interferonα2014
Author(s)
Ichiki K, Ikuta K, Addo L, Tanaka H, Sasaki Y, Shimonaka Y, Sasaki K, Ito S, Shindo M, Ohtake T, Fujiya M, Torimoto Y, Kohgo Y
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Journal Title
J ournal of Gastroenterology and Hepatology
Volume: 29(2)
Pages: 387-94
Related Report
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[Journal Article] Up-regulation of iron regulatory hormone hepcidin by interferon α.2014
Author(s)
Ichiki K, Ikuta K, Addo L, Tanaka H, Sasaki Y, Shimonaka Y, Sasaki K, Ito S, Shindo M, Ohtake T, Fujiya M, Torimoto Y, Kohgo Y.
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Journal Title
Journal of Gastroenterology and Hepatology
Volume: 29
Issue: 2
Pages: 387-394
DOI
Related Report
Peer Reviewed
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[Journal Article] Decreased vessel networks and irregular vessel on narrow band imaging are useful findings to distinguish intestinal lymphoma from lymphoid hyperplasia.2014
Author(s)
Fujiya M, Kashima S, Ikuta K, Dokoshi T, Sakatani A, Tanaka K, Ando K, Ueno N, Tominaga M, Inaba Y, Ito T, Moriichi K, Tanabe H, Saitoh Y, Kohgo Y.
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Journal Title
Gastrointestinal Endoscopy
Volume: in press
Issue: 6
Pages: 1064-71
DOI
Related Report
Peer Reviewed
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[Journal Article] Endoplasmic reticulum stress suppresses lipin-1 expression in 3T3-L1 adipocytes2013
Author(s)
Takahashi N, Yoshizaki T, Hiranaka N, Suzuki T, Yui T, Akanuma M, Kanazawa K, Yoshida M, Naito S, Fujiya M, Kohgo Y, Ieko M
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Journal Title
BBRC
Volume: 431(1)
Pages: 25-30
NAID
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[Journal Article] Reduction of E-cadherin by Human Defensin-5 in Esophageal Squamous Cells.2013
Author(s)
Nomura Y, Tanabe H, Moriichi K, Igawa S, Ando K, Ueno N, Kashima S, Tominaga M, Goto T, Inaba Y, Ito T, Ishida-Yamamoto A, Fujiya M, Kohgo Y.
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Journal Title
Biochem Bioph Res Co
Volume: 439
Issue: 1
Pages: 71-77
DOI
Related Report
Peer Reviewed
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[Journal Article] Infliximab extends the duration until the first surgery in patients with Crohn’s disease.2013
Author(s)
Sakatani A, Fujiya M, Ito T, Inaba Y, Ueno N, Kashima S, Tominaga M, Moriichi K, Okamoto K, Tanabe H, Ikuta K, Ohtake T, Kono T, Furukawa H, Ashida T, Kohgo Y.
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Journal Title
Biomed Research International
Volume: 2013
Pages: 879491-879491
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] Isoleucine, an essential amino acid, induces the expression of human b-defensin 2 through the activation of the G-protein coupled receptor-ERK pathway in the intestinal epithelia2012
Author(s)
Konno Y, Ashida T, Inaba Y, Ito T, Tanabe H, Maemoto A, Ayabe T, Mizukami Y, Fujiya M, Kohgo Y
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Journal Title
Food and Nutrition Sciences
Volume: 3(4)
Pages: 548-555
Related Report
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[Journal Article] Effect of Lactobacillus brevis SBC8803 on Gamma-Glutamyl Transferase in Japanese Habitual Drinkers : A Double-Blind, Placebo-Controlled Study2012
Author(s)
Wakita Y, Shimizu C, Nakakita Y, Kaneda H, Kanda H, Segawa S, Shigyou T, Ohtake T, Fujiya M, Kohgo Y
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Journal Title
Food and Nutrition Sciences
Volume: 3(5)
Pages: 678-684
Related Report
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[Journal Article] Paneth Cells Regulate Both Chemotaxis of Immature Dendritic Cells and Cytokine Production from Epithelial Cells2012
Author(s)
Ito T, Ayabe T, Ishikawa C, Inaba Y, Tanabe H, Maemoto A, Kono T, Ashida T, Fujiya M, Kohgo Y.
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Journal Title
The Tohoku Journal of Experimental Medicine
Volume: 227
Issue: 1
Pages: 39-48
DOI
NAID
ISSN
0040-8727, 1349-3329
Related Report
Peer Reviewed
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[Journal Article] Isoleucine, an essential amino acid, induces the expression of human  defensin 2 through the activation of the G-protein coupled receptor-ERK pathway in the intestinal epithelia.2012
Author(s)
Konno Y, Ashida T, Inaba Y, Ito T, Tanabe H, Maemoto A, Ayabe T, Mizukami Y, Fujiya M, Kohgo Y.
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Journal Title
Food and Nutrition Sciences
Volume: 3
Issue: 04
Pages: 548-555
DOI
Related Report
Peer Reviewed
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[Journal Article] Pseudo-diverticular formation due to a cytomegalovirus infection in the colorectum.2012
Author(s)
Muto M, Sato R, Fujiya M, Tanaka K, Serikawa S, Hayashi A, Konno Y, Sakamoto J, Nishikawa T, Oikawa K, Ueno N, Ikuta K, Mizukami Y, Tanno S, Watari J, Kohgo Y.
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Journal Title
Digestive Endoscopy
Volume: 24
Issue: 3
Pages: 193-193
DOI
Related Report
Peer Reviewed
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[Journal Article] Back-to-Back Comparison of Auto-Fluorescence Imaging (AFI) versus High Resolution White Light Colonoscopy for Adenoma Detection.2012
Author(s)
Moriichi K, Fujiya M, Sato R, Watari J, Nomura Y, Nata T, Ueno N, Maeda S, Kashima S, Itabashi K, Ishikawa C, Inaba Y, Ito T, Okamoto K, Tanabe H, Mizukami Y, Saitoh Y, Kohgo Y.
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Journal Title
BMC Gastroenterology
Volume: 12
Issue: 1
Pages: 75-75
DOI
Related Report
Peer Reviewed
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[Journal Article] Competence and sporulation factor derived from Bacillus subtilis improves epithelial cell injury in intestinal inflammation via immunomodulation and cytoprotection2012
Author(s)
Okamoto K, Fujiya M, Nata T, Ueno N, Inaba Y, Ishikawa C, Ito T, Moriichi K, Tanabe H, Mizukami Y, Chang EB, Kohgo Y
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Journal Title
Int J Colorectal Diseases
Volume: (in press)
Issue: 8
Pages: 1039-46
DOI
Related Report
Peer Reviewed
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[Journal Article] Autofluorescence imaging and the quantitative intensity of fluorescence for evaluating the dysplastic grade of colonic neoplasms.2012
Author(s)
Moriichi K, Fujiya M, Sato R, Nata T, Nomura Y, Ueno N, Ishikawa C, Inaba Y, Ito T, Okamoto K, Tanabe H, Mizukami Y, Watari J, Saitoh Y, Kohgo Y.
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Journal Title
Int J Colorectal Diseases
Volume: 27 (3)
Pages: 325-330
Related Report
Peer Reviewed
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[Journal Article] Biomarkers predicting development of metachronous after endoscopic resection: an analysis of molecular pathology of Helicobactor pylori eradication.2012
Author(s)
Watari J, Moriichi K, Tanabe H, Kashima S, Nomura Y, Fujiya M, Tomita T, Oshima T, Fukui H, Miwa H, Das KM, Kohgo Y.
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Journal Title
Int J Cancer
Volume: 130(10)
Pages: 2349-58
Related Report
Peer Reviewed
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[Journal Article] Suppression of lipin-1 expression increases monocyte chemoattractant protein-1 expression in 3T3-L1 adipocytes2011
Author(s)
Takahashi N, Yoshizaki T, Hiranaka N, Suzuki T, Yui T, Akanuma M, Oka K, Kanazawa K, Yoshida M, Naito S, Fujiya M, Kohgo Y, Ieko M
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Journal Title
Biochem Biophys Res Commun
Volume: 11;415(1)
Pages: 200-5
NAID
Related Report
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[Journal Article] Suppression of lipin-1 expression increases monocyte chemoattractant protein-1 expression in 3T3-L1 adipocytes.2011
Author(s)
Takahashi N, Yoshizaki T, Hiranaka N, Suzuki T, Yui T, Akanuma M, Oka K, Kanazawa K, Yoshida M, Naito S, Fujiya M, Kohgo Y, Ieko M.
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Journal Title
Biochem Biophys Res Commun
Volume: 415(1)
Pages: 200-5
NAID
Related Report
Peer Reviewed
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[Journal Article] The diagnostic accuracy of high-resolution endoscopy, autofluorescence imaging and narrow-band imaging for differentially diagnosing colon adenoma.2011
Author(s)
Sato R, Fujiya M, Watari J, Ueno N, Moriichi K, Kashima S, Maeda S, Ando K, Kawabata H, Sugiyama R, Nomura Y, Nata T, Itabashi K, Inaba Y, Okamoto K, Mizukami Y, Saitoh Y, Kohgo Y.
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Journal Title
Endoscopy
Volume: 43(10)
Pages: 862-8
NAID
Related Report
Peer Reviewed
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[Journal Article] Endosopic auto-fluorescence imaging is useful for the differential diagnosis of intestinal lymphomas resembling lymphoid heyperplasia.2011
Author(s)
Ueno N, Fujiya M, Moriichi K, Ikuta K, Nata T, Konno Y, Ishikawa C, Inaba Y, Ito T, Sato R, Okamoto K, Tanabe H, Maemoto A, Sato K, Watari J, Ashida T, Saitoh Y, Kohgo Y.
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Journal Title
J Clin Gastroenterol
Volume: 45(6)
Pages: 507-13
Related Report
Peer Reviewed
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[Journal Article] a Japanese traditional medicine, blocks DSS-induced intestinal inflammation and damage
Author(s)
Ueno N, Hasebe T, Kaneko A, Yamamoto M, Wang Y, Fujiya M, Kohgo Y, Kono T, Musch MW, Chang EB. Daikenchuto
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Journal Title
PloS One
Volume: (in press)
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[Presentation] Long-term oral dietary administration of a new probiotic, Lactobacillus brevis SBC8803, alters gut the microbiota and ameliorates DSS-induced colitis in mice.2014
Author(s)
Ueno N, Fujiya M, Segawa S, Konishi H, Sakatani A, Tanaka K, Dokoshi T, Ando K, Kashima S, Inaba Y, Ito T, Moriichi K, Shigyo T, Kohgo Y.
Organizer
DDW 2014 (AGA)
Place of Presentation
Chicago
Related Report
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[Presentation] A bamboo-like appearance is a characteristic finding of the upper GI in patients with Crohn’s disease.2013
Author(s)
Sakatani A, Fujiya M, Kashima S, Tanabe H, Dokoshi T, Tanaka K, Ando K, Ueno N, Tominaga M, Inaba Y, Ito T, Moriichi K, Kohgo Y.
Organizer
DDW 2013 (ASGE)
Place of Presentation
Orland
Related Report
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[Presentation] Probiotic-derived polyphosphate inhibits colon cancer progression through the inactivation of the ERK pathway and the induction of cancer cell apoptosis.2013
Author(s)
Sakatani A, Fujiya M, Konishi H, Segawa S, Kashima S, Ueno N, Tanaka K, Dokoshi T, Ando K, Tominaga M, Inaba Y, Ito T, Tanabe H, Moriichi K, Kohgo Y.
Organizer
DDW 2013 (AGA)
Place of Presentation
Orland
Related Report
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[Presentation] A probiotic-derived polyphosphate improves chronic inflammation and fibrosis via caveolin-dependent endocytosis.2013
Author(s)
Konishi H, Fujiya M, Segawa S, Kashima S, Ueno N, Tanaka K, Sakatani A, Dokoshi T, Ando K, Tominaga M, Inaba Y, Ito T, Tanabe H, Moriichi K, Kohgo Y.
Organizer
DDW 2013 (AGA)
Place of Presentation
orland
Related Report
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[Presentation] Treatment with the heat-killed body of Lactobacillus brevis SBC8803 ameliorates intestinal injury in a dextran sulfate sodium-induced chronic colitis model by enhancing the intestinal barrier function.2013
Author(s)
Ueno N, Fujiya M, Segawa S, Dokoshi T, Ando K, Inaba Y, Moriichi K, Tanabe H, Kobayashi N, Shigyo T, Kohgo Y.
Organizer
1st annual meeting of Asian Organization for Crohn's & Colitis (AOCC)
Place of Presentation
Tokyo
Related Report
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[Presentation] The operative time for endoscopic submucosal dissection can be estimated based on the size and endoscopically described area of the lesion.2013
Author(s)
Fujiya M, Tominaga M, Moriichi K, Tanaka K, Dokoshi T, Sakatani A, Ando K, Ueno N, Kashima S, Inaba Y, Ito T, Tanabe H, Ikuta K, Kohgo Y.
Organizer
1st International Conference of Federation of Asian Clinical Oncology (FACO)
Place of Presentation
Xiamen
Related Report
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[Presentation] A probiotic-derived polyphosphate improves chronic inflammation and fibrosis via caveolin-dependent endocytosis.2013
Author(s)
Konishi H, Fujiya M, Segawa S, Kashima S, Ueno N, Tanaka K, Sakatani A, Dokoshi T, Ando K, Tominaga M, Inaba Y, Ito T, Tanabe H, Moriichi K, Kohgo Y
Organizer
DDW 2013 (AGA)
Place of Presentation
Orland
Related Report
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[Presentation] Polyphosphate is a novel active molecule derived from Lactobacillus brevis that contributes to the maintenance of intestinal homeostasis and the improvement of intestinal injury in acute and chronic experimental colitis.
Author(s)
Fujiya M, Ueno N, Sakatani A, Dokoshi T, Ando K, Nomura Y, Kashima S, Tominaga M, Inaba Y, Ito T, Moriichi K, Kikuchi Y, Okamoto K, Tanabe H, Segawa S, Kobayashi N, Shigyo T, Kohgo Y.
Organizer
DDW 2012 (AGA)
Place of Presentation
San Diego
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