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To determine a disease pathway related with NKX2.3 in inflammatory bowel disease

Research Project

Project/Area Number 23590932
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Gastroenterology
Research InstitutionTohoku University

Principal Investigator

KINOUCHI Yoshitaka  東北大学, 高等教育開発推進センター, 教授 (20250780)

Co-Investigator(Kenkyū-buntansha) KAKUTA Yoichi  東北大学, 大学病院, 助教 (50509205)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords炎症性腸疾患 / NKX2.3 / クローン病 / 潰瘍性大腸炎 / 感受性遺伝子
Research Abstract

NKX2.3 is expressed in endothelial cells and is considered to be one of the candidate susceptibility genes to inflammatory bowel diseases. In this study, to investigate how NKX2.3 influences disease susceptibilities to inflammatory bowel diseases, we determined the genes regulated by NKX2.3 in endothelial cells using expression analysis and ChIP on Chip. A total of 34 genes including MAdCAM-1 were determined in these analyses. Enriched GO terms were revealed to be inflammatory response and cell proliferation using DAVID. To determine the binding site in the promoter region of the MAdCAM-1, the promoter assay using pGL4 plasmid and electrophoretic mobility shift assay were performed. But we have not found the binding site in the promoter region of the MAdCAM-1.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (4 results)

All 2014 2013

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (2 results)

  • [Journal Article] Modulation of endoplasmic reticulum (ER) stress-induced autophagy by C/EBP homologous protein (CHOP) and inositol- requiring enzyme 1α(IRE1α) human colon cancer cells2014

    • Author(s)
      Shimodaira Y, Takahashi S, Kinouchi Y, et al
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 445 Issue: 2 Pages: 524-533

    • DOI

      10.1016/j.bbrc.2014.02.054

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Modulation of endoplasmic reticulum (ER) stress-induced autophagy by C/EBP homologous protein (CHOP) and inositol-requiring enzyme 1α (IRE1α) in human colon cancer cells.2014

    • Author(s)
      Shimodaira Y, Takahashi S, Kinouchi Y, et al.
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 445 Pages: 524-533

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Presentation] Autophagy is induced by ERstress mainly through IRE1alpha in human colon cancer cells and it plays a cytoprotective role2013

    • Author(s)
      Shimodaira Y, Takahashi S, Shiga H, Kakuta Y, Kinouchi Y, Shimosegawa T
    • Organizer
      21th United European Gastroenterology Week
    • Place of Presentation
      ドイツ・ベルリン
    • Year and Date
      2013-10-14
    • Related Report
      2013 Final Research Report
  • [Presentation] Autophagy is induced by ERstress mainly through IRE1alpha in human colon cancer cells and it plays a cytoprotective role.2013

    • Author(s)
      Shimodaira Y, Takahashi S, Shiga H, Kakuta Y, Kinouchi Y, Shimosegawa T.
    • Organizer
      21th United European Gastroenterology Week
    • Place of Presentation
      ドイツ ベルリン
    • Related Report
      2013 Annual Research Report

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Published: 2011-08-05   Modified: 2019-07-29  

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