| Project/Area Number |
23590938
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | The Tazuke Kofukai (2013)
Kyoto University (2011-2012) |
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Principal Investigator |
NISHIMURA Takafumi 公益財団法人田附興風会, 医学研究所 第1研究部, 研究主幹 (40378732)
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| Co-Investigator(Renkei-kenkyūsha) |
NISHIDA Naoshi 近畿大学, 医学部, 准教授 (60281755)
OKABE Hiroshi 京都大学, 医学(系)研究科(研究院), 准教授 (10335250)
KAWAMURA Jun-ichirou 京都大学, 医学(系)研究科(研究院), 准教授 (90422948)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | 結腸直腸癌 / 化学療法 / 予後因子 / 染色体異常 / 遺伝子増幅 / SNPアレイ / 下部消化管学 |
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| Research Abstract |
FOLFOX (folic acid, 5-FU and oxaliplatin) therapy is widely used to treat patients with metastatic colorectal cancer. This study was conducted to elucidate the impact of gains or losses at specific regions of chromosomes on the outcome of FOLFOX therapy. DNA copy changes were analyzed on the genomic DNA extracted from tumor and non-tumor tissues obtained at the time of surgery who had synchronous liver metastases using single nucleotide polymorphism array. Tumors with retained long arm of chromosome 8 and lost long arm of chromosome 18 showed poorer survival. Tumors with 10 or more aberrant chromosomes also showed poor survival. In conclusion, patients with complex chromosomes showed poor outcome after FOLFOX therapy.
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