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Elucidation of activation mechanism of insulin-like growth factor and development of therapy using neutralizing antibody in the gastrointestinal cancers

Research Project

Project/Area Number 23590939
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Gastroenterology
Research InstitutionKyoto University

Principal Investigator

MIYAMOTO Shin'ichi  京都大学, 医学(系)研究科(研究院), 助教 (90378761)

Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywordsがん / シグナル伝達 / 分子標的薬 / インスリン様増殖因子 / 中和抗体 / 分子標的治療 / 腫瘍微小環境 / バイオマーカー / 活性型インスリン様増殖因子 / 肝転移
Research Abstract

It is necessary for the cancer cells to adapt to the tissue microenvironment for the metastasis formation in other ogans. Colon cancer cells highly metastasize to the liver and control of liver metastasis is most important issue in the therapeutic strategy of colon cancer. We clarified that liver-derived insulin-like growth factors (IGFs) activated by cancer-producing protease play an important role for the liver metastasis formation and could be a therapeutic target using neutralizing antibody. Furthermore, we developed the measurement system of activted (bioactive) IGF in the blood and demonstrated that bioactive IGF was increased with progressio of liver metastais and could be a biomarker of IGF neutralizing strategy in the mouse model.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (28 results)

All 2014 2012 2011 Other

All Journal Article (19 results) (of which Peer Reviewed: 19 results) Presentation (2 results) Book (2 results) Remarks (5 results)

  • [Journal Article] Multimodal endoscopic treatment for delayed severe esophageal stricture caused by incomplete stent removal2014

    • Author(s)
      Setoyma T, Miyamoto S, Horimatsu T, Morita S, Ezoe Y, Muto M, Watanabe G, Tanaka E, Chiba T
    • Journal Title

      Dis Esophagus

      Volume: 2 Issue: 2 Pages: 7112-115

    • DOI

      10.1111/dote.12041

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Stability of acetaldehyde-derived DNA adduct in vitro.2012

    • Author(s)
      Hori K.
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 423 Issue: 4 Pages: 642-646

    • DOI

      10.1016/j.bbrc.2012.05.158

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] A case of long-term survival of metastatic desmoplastic small round cell tumor treated with multimodal therapy2012

    • Author(s)
      Watanabe T, Miyamoto S, Kitagori K, Horimatsu T, Morita S, Mashimo Y, Ezoe Y, Muto M, Chiba T
    • Journal Title

      Oncol Lett

      Volume: 3(1) Issue: 1 Pages: 30-34

    • DOI

      10.3892/ol.2011.457

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Hemosuccus pancreaticus diagnosed with concurrent endoscopic retrograde pancreatography and selective angiography.2012

    • Author(s)
      Setoyama T.
    • Journal Title

      Clin Gastroenterol Hepatol.

      Volume: 10 Issue: 4 Pages: A28-A28

    • DOI

      10.1016/j.cgh.2011.10.024

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Education and gastrointestinal imaging: case of early-stage squamous cell carcinoma of the anal canal diagnosed using narrow-band imaging system with magnification.2012

    • Author(s)
      Horimatsu T.
    • Journal Title

      J Gastroenterol Hepatol.

      Volume: 27 Issue: 8 Pages: 1468-1468

    • DOI

      10.1111/j.1440-1746.2012.07182.x

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Cerebral air embolism caused by chemoradiotherapy for esophageal cancer.2012

    • Author(s)
      Miyamoto S.
    • Journal Title

      J Clin Oncol.

      Volume: 30 Issue: 25 Pages: e237-e238

    • DOI

      10.1200/jco.2012.41.6156

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Cancer risk and management in a woman with Peutz-Jeghers syndrome.2012

    • Author(s)
      Yasumoto K.
    • Journal Title

      Int Canc Conf J

      Volume: -

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] A case of long-term survival of metastatic desmoplastic small round cell tumor treated with multimodal therapy.2012

    • Author(s)
      Watanabe T.
    • Journal Title

      Oncol Lett.

      Volume: 3 Pages: 30-34

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Usefulness of endoscopic radial incision and cutting method for refractory esophagogastric anastomotic stricture (with video).2012

    • Author(s)
      Muto M.
    • Journal Title

      Gastrointest Endosc.

      Volume: 75 Issue: 5 Pages: 965-972

    • DOI

      10.1016/j.gie.2012.01.012

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Tissue damage in the canine normal esophagus by photoactivation with talaporfin sodium (laserphyrin): a preclinical study.2012

    • Author(s)
      Horimatsu T.
    • Journal Title

      PLoS One.

      Volume: 7 Issue: 6 Pages: e38308-e38308

    • DOI

      10.1371/journal.pone.0038308

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Acute Airway Obstruction in a Patient with Achalasia2011

    • Author(s)
      Miyamoto S, Konda Y, Matsui M, Sawada K, Ikeda K, Watanabe N, Kawanami C, Chiba T
    • Journal Title

      Internal Medicine

      Volume: 50 Issue: 20 Pages: 2333-2336

    • DOI

      10.2169/internalmedicine.50.5603

    • NAID

      130001087742

    • ISSN
      0918-2918, 1349-7235
    • Related Report
      2013 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] An unusual cause of dysphagia after endoscopic resection of an early esophageal cancer2011

    • Author(s)
      Nakanishi Y, Miyamoto S, Ishizu S, Seno H, Muto M, Chiba T
    • Journal Title

      Endoscopy

      Volume: 43 Suppl 2 Issue: S 02 Pages: E156-E157

    • DOI

      10.1055/s-0030-1256260

    • Related Report
      2013 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Pharmacokinetics of oxaliplatin in a hemodialytic patient treated with modified FOLFOX-6 plus bevacizumab therapy2011

    • Author(s)
      Horimatsu T, Miyamoto S, Morita S, Mashimo Y, Ezoe Y, Muto M, Chiba T
    • Journal Title

      Cancer Chemother Pharmacol

      Volume: 68(1) Issue: 1 Pages: 263-6

    • DOI

      10.1007/s00280-011-1633-9

    • Related Report
      2013 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Umbilical Metastasis (Sister Mary Joseph's Nodule) From Esophageal Squamous Cell Carcinoma2011

    • Author(s)
      Mashimo Y, Horimatsu T, Miyamoto S
    • Journal Title

      Clin Gastroenterol Hepatol

      Volume: 9(8) Issue: 8 Pages: A20-A20

    • DOI

      10.1016/j.cgh.2011.02.023

    • Related Report
      2013 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Early detection of 5-FU-induced acute leukoencephalopathy on diffusion-weighted MRI2011

    • Author(s)
      Akitake R, Miyamoto S, Nakamura F, Horimatsu T, Ezoe Y, Muto M, Chiba T
    • Journal Title

      Jpn J Clin Oncol

      Volume: 41(1) Issue: 1 Pages: 121-4

    • DOI

      10.1093/jjco/hyq157

    • Related Report
      2013 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Differences of image enhancement in image-enhanced endoscopy: narrow band imaging versus flexible spectral imaging color enhancement.2011

    • Author(s)
      Muto M, Higuchi H, Ezoe Y, Horimatsu T, Morita S, Miyamoto S, Chiba T.
    • Journal Title

      J Gastroenterol.

      Volume: 46 Issue: 8 Pages: 998-1002

    • DOI

      10.1007/s00535-011-0419-5

    • NAID

      10029563212

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Long-term outcome of transoral organ-preserving pharyngeal endoscopic resection for superficial pharyngeal cancer.2011

    • Author(s)
      Muto M, Satake H, Yano T, Minashi K, Hayashi R, Fujii S, Ochiai A, Ohtsu A, Morita S, Horimatsu T, Ezoe Y, Miyamoto S, Asato R, Tateya I, Yoshizawa A, Chiba T.
    • Journal Title

      Gastrointest Endosc.

      Volume: 74 Issue: 3 Pages: 477-484

    • DOI

      10.1016/j.gie.2011.04.027

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Endoscopic features of sessile serrated adenoma and other serrated colorectal polyps.2011

    • Author(s)
      Yamada A, Notohara K, Aoyama I, Miyoshi M, Miyamoto S, Fujii S, Yamamoto H.
    • Journal Title

      Hepatogastroenterology

      Volume: 58 Pages: 45-51

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Efficacy of preventive endoscopic balloon dilation for esophageal stricture after endoscopic resection.2011

    • Author(s)
      Ezoe Y, Muto M, Horimatsu T, Morita S, Miyamoto S, Mochizuki S, Minashi K, Yano T, Ohtsu A, Chiba T.
    • Journal Title

      J Clin Gastroenterol.

      Volume: 45 Issue: 3 Pages: 222-227

    • DOI

      10.1097/mcg.0b013e3181f39f4e

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] 食道癌化学放射線療法後の表在性局所遺残・再発病変に対する内視鏡的salvage EMR/ESDの成績2012

    • Author(s)
      菊池理.
    • Organizer
      日本消化器内視鏡学会近畿支部第89回支部例会
    • Place of Presentation
      大阪国際会議場(大阪)
    • Related Report
      2012 Research-status Report
  • [Presentation] ワークショップ7-2大腸がんに対するインスリン様増殖因子の治療標的としての有用性-発がんから肝転移まで-2011

    • Author(s)
      宮本心一
    • Organizer
      第7回日本消化管学会総会学術集会
    • Place of Presentation
      京都
    • Year and Date
      2011-02-18
    • Related Report
      2013 Final Research Report
  • [Book] Multiple early-stage malignant melanoma of the esophagus with a long follow-up period after endoscopic treatment : report of a case and a literature review. Esophageal Cancer–Cell and Molecular Biology, Biomarkers, Nutrition and Treatment Croatia2012

    • Author(s)
      Miyamoto S, Morita S, Muto M
    • Publisher
      INTECH
    • Related Report
      2013 Final Research Report
  • [Book] ESOPHAGEAL CANCER CELL AND MOLECULAR BIOLOGY, BIOMARKERS, NUTRITION AND TREATMENT2012

    • Author(s)
      Miyamoto S.
    • Publisher
      INTECH(Croatia)
    • Related Report
      2012 Research-status Report
  • [Remarks]

    • URL

      http://www.kuhp.kyoto-u.ac.jp/~gastro/mmuto/

    • Related Report
      2013 Final Research Report
  • [Remarks] 京都大学医学部附属病院 武藤学研究室

    • URL

      http://www.kuhp.kyoto-u.ac.jp/~gastro/mmuto/

    • Related Report
      2013 Annual Research Report
  • [Remarks] 武藤学研究室

    • URL

      http://www.kuhp.kyoto-u.ac.jp/~gastro/mmuto/

    • Related Report
      2012 Research-status Report
  • [Remarks]

    • URL

      http://www.kuhp.kyoto-u.ac.jp/~gastro/mmuto/

    • Related Report
      2011 Research-status Report
  • [Remarks] 京都大学 武藤学 研究室

    • Related Report
      2011 Research-status Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

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