Elucidation of activation mechanism of insulin-like growth factor and development of therapy using neutralizing antibody in the gastrointestinal cancers
Project/Area Number |
23590939
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Gastroenterology
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Research Institution | Kyoto University |
Principal Investigator |
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Project Period (FY) |
2011 – 2013
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Project Status |
Completed (Fiscal Year 2013)
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Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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Keywords | がん / シグナル伝達 / 分子標的薬 / インスリン様増殖因子 / 中和抗体 / 分子標的治療 / 腫瘍微小環境 / バイオマーカー / 活性型インスリン様増殖因子 / 肝転移 |
Research Abstract |
It is necessary for the cancer cells to adapt to the tissue microenvironment for the metastasis formation in other ogans. Colon cancer cells highly metastasize to the liver and control of liver metastasis is most important issue in the therapeutic strategy of colon cancer. We clarified that liver-derived insulin-like growth factors (IGFs) activated by cancer-producing protease play an important role for the liver metastasis formation and could be a therapeutic target using neutralizing antibody. Furthermore, we developed the measurement system of activted (bioactive) IGF in the blood and demonstrated that bioactive IGF was increased with progressio of liver metastais and could be a biomarker of IGF neutralizing strategy in the mouse model.
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Report
(4 results)
Research Products
(28 results)
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[Journal Article] Long-term outcome of transoral organ-preserving pharyngeal endoscopic resection for superficial pharyngeal cancer.2011
Author(s)
Muto M, Satake H, Yano T, Minashi K, Hayashi R, Fujii S, Ochiai A, Ohtsu A, Morita S, Horimatsu T, Ezoe Y, Miyamoto S, Asato R, Tateya I, Yoshizawa A, Chiba T.
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Journal Title
Gastrointest Endosc.
Volume: 74
Issue: 3
Pages: 477-484
DOI
Related Report
Peer Reviewed
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