| Project/Area Number |
23590941
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Osaka University |
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Principal Investigator |
IIJIMA Hideki 大阪大学, 医学(系)研究科(研究院), 講師 (90444520)
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| Co-Investigator(Kenkyū-buntansha) |
MASAHIKO Tsujii 大阪大学, 医学系研究科, 准教授 (40303937)
TSUTOMU Nishida 大阪大学, 医学系研究科, 助教 (20467575)
SHINICHIRO Shinzaki 大阪大学, 医学系研究科, 助教 (60546860)
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| Co-Investigator(Renkei-kenkyūsha) |
HIROSHI Kiyono 東京大学, 医科学研究所, 教授 (10271032)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 小腸粘膜傷害 / NSAID / 粘膜免疫 / パイエル板 / 樹状細胞 / ＮＳＡＩＤ / 小腸粘膜障害 / ＮＳＡＩＤｓ / CD103陽性樹状細胞 / NSAIDｓ |
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| Research Abstract |
We investigated the role of Peyer's patches (PPs) in mouse model of non-steroidal anti-inflammatory drug (NSAID)-induced enteropathy. We found PP-null mice showed greater indomethacin-induced enteropathy than the wild type mice. The proportion of CD103+ DCs and IL-10 expressing CD4+ T cells of PPs increased after indomethacin treatment. Protective effect was not associated with commensal bacteria. These results indicate that PPs play a protective role in NSAID-induced enteropathy, and this protection is associated with an increase in CD103+ DCs and IL-10 producing CD4+ T cells in the intestine. PPs are considered to be a target for digestive inflammatory diseases.
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