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Regenerative therapy using autogenic adipocyte-derived progenitor cells for radiation colitis

Research Project

Project/Area Number 23590946
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Gastroenterology
Research InstitutionFukushima Medical University

Principal Investigator

OHTSURU Akira  福島県立医科大学, 医学部, 教授 (00233198)

Co-Investigator(Kenkyū-buntansha) ISOMOTO Hajime  長崎大学, 大学病院, 准教授 (90322304)
MAKASHIMA Masahiro  長崎大学, 原爆後障害医療研修所, 教授 (50284683)
YOSHIMOTO Hiroshi  長崎大学, 大学病院, 助教 (90513309)
Project Period (FY) 2011-04-28 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2014: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords放射線晩発性障害 / スクリーニング / 多分化能 / 再生阻害局所環境 / 間葉系前駆細胞 / 放射線障害 / 放射線皮膚潰瘍 / 放射線腸炎 / 急性放射線症候群 / 緊急被ばく医療
Outline of Final Research Achievements

Radiation-induced intestinal and skin injury is one of the most life-threatening diseases in acute radiation syndrome. Although there is no patient of acute radiation syndrome in Fukushima Daiichi Nuclear Power Plant (NPP) accident compared to past nuclear disaster, it is an important issue to discover how to reduce the radiation-induced skin and intestinal damage in preparation for accident medical responses in high dose circumstances for long-term reactor decommissioning. We have been developing a regenerative therapy system using non-cultured autologous adipose-derived stem cells. Furthermore, we have developed a novel system to generate multilineage progenitor cells from normal tissues. To establish a strategy for a rapid screening survey of surface contamination among a large number of people after NPP accidents, we analyzed the measured surface contamination of subjects. It is a strategy to screen a possible deterministic effect including radiation colitis.

Report

(5 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (17 results)

All 2015 2014 2013 2012 2011

All Journal Article (11 results) (of which Peer Reviewed: 11 results,  Open Access: 5 results,  Acknowledgement Compliant: 1 results) Presentation (3 results) (of which Invited: 1 results) Book (3 results)

  • [Journal Article] Systematic determination of thyroid volume by ultrasound examination from infancy to adolescence in Japan: The Fukushima Health Management Survey2015

    • Author(s)
      Suzuki S, Midorikawa S, Fukushima T, Shimura H, Ohira T, Ohtsuru A, Abe M, Shibata Y, Yamashita S, Suzuki S.
    • Journal Title

      Endocrine Journal

      Volume: 62 Issue: 3 Pages: 261-268

    • DOI

      10.1507/endocrj.EJ14-0478

    • NAID

      130005060855

    • ISSN
      0918-8959, 1348-4540
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effect of age on the sensitivity of the rat thyroid gland to ionizing radiation.2015

    • Author(s)
      Matsuu-Matsuyama M, Shichijo K, Okaichi K, Kurashige T, Kondo H, Miura S, Nakashima M
    • Journal Title

      J Radiation Research

      Volume: 56 Issue: 3 Pages: 1-9

    • DOI

      10.1093/jrr/rrv003

    • NAID

      120006987061

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] AN OVERVIEW OF INTERNAL DOSE ESTIMATION USING WHOLE-BODY COUNTERS IN FUKUSHIMA PREFECTURE2014

    • Author(s)
      Miyazaki M, Ohtsuru A, Ishikawa T.
    • Journal Title

      FUKUSHIMA JOURNAL OF MEDICAL SCIENCE

      Volume: 60 Issue: 1 Pages: 95-100

    • DOI

      10.5387/fms.2014-10

    • NAID

      130004556149

    • ISSN
      0016-2590, 2185-4610
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A strategy for a rapid radiological screening survey in large scale radiation accidents: a lesson from our individual survey after the Fukushima Daiichi nuclear power plant accidents.2014

    • Author(s)
      T. Ohba, M. Miyazaki, H. Sato, A. Hasegawa, M. Sakuma, T. Yusa, F. Shishido, A Ohtsuru.
    • Journal Title

      Health Physics

      Volume: 107 Issue: 1 Pages: 10-17

    • DOI

      10.1097/hp.0000000000000044

    • Related Report
      2014 Annual Research Report 2013 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] EXTERNAL RADIATION DOSE ESTIMATION BY THE BASIC SURVEY2014

    • Author(s)
      Ishikawa T, Yasumura S, Ohtsuru A, Sakai A, Ohira T, Kamiya K, Abe M.
    • Journal Title

      FUKUSHIMA JOURNAL OF MEDICAL SCIENCE

      Volume: 60 Issue: 2 Pages: 207-207

    • DOI

      10.5387/fms.2014-22

    • NAID

      130004770607

    • ISSN
      0016-2590, 2185-4610
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] One-stage, simultaneous skin grafting with artificial dermis and basic fibroblast growth factor successfully improves elasticity with maturation of scar formation.2013

    • Author(s)
      Hamuy R, Kinoshita N, Yoshimoto H, Hayashida K, Houbara S, Nakashima M, Suzuki K, Mitsutake N, Mussazhanova Z, Kashiyama K, Hirano A, Akita
    • Journal Title

      Wound Repair and Regeneration

      Volume: 21(1) Issue: 1 Pages: 141-154

    • DOI

      10.1111/j.1524-475x.2012.00864.x

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Spatiotemporal characteristics of internal radiation exposure in evacuees and first responders after the radiological accident in fukushima.2013

    • Author(s)
      11. Morita N, Miura M, Yoshida M, Kumagai A, Ohtsuru A, Usa T, Kudo T, Takamura N, Yamashita S, Matsuda N.
    • Journal Title

      Radiation Research

      Volume: 80 Issue: 3 Pages: 299-306

    • DOI

      10.1667/rr3372.1

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Autologous adipose-derived regenerative cells are effective for chronic intractable radiation injuries.2012

    • Author(s)
      Akita S, Yoshimoto H, Hirano A, Ohtsuru A, Yamashita S.
    • Journal Title

      Radiat Protec Dpsimetry 151(4):656-660, 2012

      Volume: 151 Pages: 656-660

    • NAID

      120006985992

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Early experiences with stem cells in treating chronic wounds.2012

    • Author(s)
      Akita S, Yoshimoto H, Akino K, Ohtsuru A, Hayashida K, Hirano A, Suzuki K, Yamashita S.
    • Journal Title

      Clin Plast Surg 39(3):281-292, 2012.

      Volume: 39 Pages: 281-292

    • NAID

      120006985986

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] MiRNA-205 modulates cellular invasion and migration via regulating zinc finger E-box binding homeobox 2 expression in esophageal squamous cell carcinoma cells2011

    • Author(s)
      K.Matsushima,H.Isomoto,N.Yamaguchi,N.Inoue H.Machida,T.Nakayama,T.Hayashi,M.Kunizaki, S. Hidaka, T. Nagayasu, M. Nakashima, K. Ujifuku, N. Mitsutake, A.Ohtsuru,S.Yamashita,et.al
    • Journal Title

      J Transl Med

      Volume: 9 Pages: 1-30

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Dedifferentiation of human primary thyrocytes into multilineage progenitor cells without gene introduction,2011

    • Author(s)
      K. Suzuki, N. Mitsutake, V. Saenko, M. Matsuse, A. Ohtsuru, A. Kumagai, T. Uga, H. Yano, Y. Nagayama, S. Yamashita,
    • Journal Title

      PLoS ONE

      Volume: 27

    • NAID

      120006985082

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] Lecture on Radiation Disaster Preparedness2015

    • Author(s)
      A. Kumagai, T. Ohba, A. Ohtsuru
    • Organizer
      National Institute of Public Health Conference, Kingdom of Cambodia
    • Place of Presentation
      Phnom Penh, Cambodia
    • Year and Date
      2015-02-11 – 2015-02-15
    • Related Report
      2014 Annual Research Report
  • [Presentation] Fukushima Health Management Survey2014

    • Author(s)
      A. Ohtsuru
    • Organizer
      The 14th Coordination and Planning Meeting of the WHO REMPAN
    • Place of Presentation
      Wuerzburg, Germany
    • Year and Date
      2014-05-07 – 2014-05-09
    • Related Report
      2014 Annual Research Report
  • [Presentation] Radiation Exposure in Fukushima Residents after the Disaster. Fukushima Nuclear Power Plant Accident: Medical Emergency, Radiation Exposure in Residents and Workers, and Food Contamination and its Monitoring2013

    • Author(s)
      A. Ohtsuru
    • Organizer
      Society of Nuclear Medicine and Molecular Imaging Annual Meeting
    • Place of Presentation
      Vancouver, Canada
    • Related Report
      2013 Research-status Report
    • Invited
  • [Book] A New Challenge of Radiation Health Risk Management2012

    • Author(s)
      A. Ohtsuru, S. Akita, A. Kumagai, H. Isomoto, T. Usa, K. Suzuki, A.Hirano, S. Yamashita.
    • Total Pages
      276
    • Publisher
      Nagasaki Newspaper Publish
    • Related Report
      2012 Research-status Report
  • [Book] Development of novel treatments for radiation-related diseases in nuclear power plant acciden . ANew Challenge of Radiation Health Risk Management NAKASHIMA,M et.al.(eds)2012

    • Author(s)
      OHTSURU,A*:AKITA,S:KUMAGAI,A*:ISOMOTO,H:USA,T:SUZUKI,K:HIRANO,A:YAMASHITA,S*
    • Publisher
      Nagasaki Newspaper Publish
    • Related Report
      2011 Research-status Report
  • [Book] Fukushima daiichi nuclear power plant accicent and emergency medical response at Fukushima Medical University Hospital. A New Challenge of Radiation Health Risk Management. NAKASHIMA,M et.al.(eds)2012

    • Author(s)
      HASEGAWA,A*:MIYAZAKI,M*:TASE,C*:KUMAGAI,A*:OHTSURU,A*
    • Publisher
      Nagasaki Newspaper Publish
    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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