Regenerative therapy using autogenic adipocyte-derived progenitor cells for radiation colitis
| Project/Area Number |
23590946
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Fukushima Medical University |
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Principal Investigator |
OHTSURU Akira 福島県立医科大学, 医学部, 教授 (00233198)
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| Co-Investigator(Kenkyū-buntansha) |
ISOMOTO Hajime 長崎大学, 大学病院, 准教授 (90322304)
MAKASHIMA Masahiro 長崎大学, 原爆後障害医療研修所, 教授 (50284683)
YOSHIMOTO Hiroshi 長崎大学, 大学病院, 助教 (90513309)
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| Project Period (FY) |
2011-04-28 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2014: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 放射線晩発性障害 / スクリーニング / 多分化能 / 再生阻害局所環境 / 間葉系前駆細胞 / 放射線障害 / 放射線皮膚潰瘍 / 放射線腸炎 / 急性放射線症候群 / 緊急被ばく医療 |
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| Outline of Final Research Achievements |
Radiation-induced intestinal and skin injury is one of the most life-threatening diseases in acute radiation syndrome. Although there is no patient of acute radiation syndrome in Fukushima Daiichi Nuclear Power Plant (NPP) accident compared to past nuclear disaster, it is an important issue to discover how to reduce the radiation-induced skin and intestinal damage in preparation for accident medical responses in high dose circumstances for long-term reactor decommissioning. We have been developing a regenerative therapy system using non-cultured autologous adipose-derived stem cells. Furthermore, we have developed a novel system to generate multilineage progenitor cells from normal tissues. To establish a strategy for a rapid screening survey of surface contamination among a large number of people after NPP accidents, we analyzed the measured surface contamination of subjects. It is a strategy to screen a possible deterministic effect including radiation colitis.
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Report
(5 results)
Research Products
(17 results)
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[Journal Article] Systematic determination of thyroid volume by ultrasound examination from infancy to adolescence in Japan: The Fukushima Health Management Survey2015
Author(s)
Suzuki S, Midorikawa S, Fukushima T, Shimura H, Ohira T, Ohtsuru A, Abe M, Shibata Y, Yamashita S, Suzuki S.
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Journal Title
Endocrine Journal
Volume: 62
Issue: 3
Pages: 261-268
DOI
NAID
ISSN
0918-8959, 1348-4540
Related Report
Peer Reviewed / Open Access
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[Journal Article] One-stage, simultaneous skin grafting with artificial dermis and basic fibroblast growth factor successfully improves elasticity with maturation of scar formation.2013
Author(s)
Hamuy R, Kinoshita N, Yoshimoto H, Hayashida K, Houbara S, Nakashima M, Suzuki K, Mitsutake N, Mussazhanova Z, Kashiyama K, Hirano A, Akita
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Journal Title
Wound Repair and Regeneration
Volume: 21(1)
Issue: 1
Pages: 141-154
DOI
Related Report
Peer Reviewed
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[Journal Article] MiRNA-205 modulates cellular invasion and migration via regulating zinc finger E-box binding homeobox 2 expression in esophageal squamous cell carcinoma cells2011
Author(s)
K.Matsushima,H.Isomoto,N.Yamaguchi,N.Inoue H.Machida,T.Nakayama,T.Hayashi,M.Kunizaki, S. Hidaka, T. Nagayasu, M. Nakashima, K. Ujifuku, N. Mitsutake, A.Ohtsuru,S.Yamashita,et.al
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Journal Title
J Transl Med
Volume: 9
Pages: 1-30
Related Report
Peer Reviewed
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[Journal Article] Dedifferentiation of human primary thyrocytes into multilineage progenitor cells without gene introduction,2011
Author(s)
K. Suzuki, N. Mitsutake, V. Saenko, M. Matsuse, A. Ohtsuru, A. Kumagai, T. Uga, H. Yano, Y. Nagayama, S. Yamashita,
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Journal Title
NAID
Related Report
Peer Reviewed
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