The mechanism of action of strong anti-inflammatory effects in novel Lactobacillus probiotic strains isolated from Japanese "Funazushi"
| Project/Area Number |
23590954
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | National Defense Medical College |
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Principal Investigator |
Okada Yoshikiyo 防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究, 内科学, 助教 (90531137)
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| Co-Investigator(Renkei-kenkyūsha) |
Hokari Ryota 防衛医科大学, 内科学講座, 教授 (90255464)
Miura Soichiro 防衛医科大学, 学校長 (50138012)
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| Research Collaborator |
Tsuzuki Yoshikazu 埼玉医科大学, 消化管内科 (10236929)
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| Project Period (FY) |
2011-04-28 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2015: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2014: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2013: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 発酵食品 / プロバイオティクス / 抗炎症作用 / 炎症性腸疾患 / 樹状細胞 / 制御性T細胞 / Treg細胞 / 乳酸菌 / 活性化型TGF-b / av/b8インテグリン / 消化器内科 / 炎症性サイトカイン / Th17細胞 / 抗炎症性サイトカイン |
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| Outline of Final Research Achievements |
We isolated novel Lactobacillus probiotic strains from "Funazushi" that is known to Japanese traditional fermented foods. Those strains showed strong anti-inflammatory effects on DSS-induced colitis than those of L.gasseri, conventional type of probiotics. Our data also suggest that a stronger anti-inflammatory effects of those strains on DSS-induced colitis are initiated by the phenotypic change in intestinal dendritic cells characterized high β8-integrin expression, leading to induce Tregs through induction of active-form of TGF-β mediated by those DCs.
Our results demonstrated that Japanese traditional fermented foods such as "Funazushi" are valuable source for probiotics that has strong anti-inflammatory effects compared to conventional type of probiotics.
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Report
(7 results)
Research Products
(9 results)
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[Presentation] A novel probiotics isolated from Japanese "Funazushi" potently exerts a therapeutic effect on DSS-induced colitis2014
Author(s)
Yoshikiyo Okada, Yoshikazu Tsuzuki, Hirokazu Sato, Kazuyuki Narimatsu, Yuichi Yasutake, Koji Maruta, Kengo Tomita, Chikako Watanabe, Shunsuke Komoto, Chie Kurihara, Shingo Usui, Shigeaki Nagao, Soichiro Miura and Ryota Hokari
Organizer
第56回 日本消化器病学会大会(JDDW2014)
Place of Presentation
神戸
Year and Date
2014-10-23 – 2014-10-26
Related Report
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[Presentation] Probiotics isolated from Funazushi modulates NK-1R expression in colonic epithelial cells in vitro and attenuated DSS-induced colitis.2013
Author(s)
Yoshikiyo Okada, Yoshikazu Tsuzuki, Hirokazu Sato, Kazuyuki Narimatsu, Yuichi Yasutake, Ryota Hokari, Kengo Tomita, Chie Kurihara, Shunsuke Komoto, Chikako Watanabe, Atsushi Kawaguchi, Shigeaki Nagao, Soichiro Miura
Organizer
Falk Symposium 188
Place of Presentation
ドイツ、シュツットガルト
Related Report
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