| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2015: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2014: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2013: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Outline of Final Research Achievements |
We isolated novel Lactobacillus probiotic strains from "Funazushi" that is known to Japanese traditional fermented foods. Those strains showed strong anti-inflammatory effects on DSS-induced colitis than those of L.gasseri, conventional type of probiotics. Our data also suggest that a stronger anti-inflammatory effects of those strains on DSS-induced colitis are initiated by the phenotypic change in intestinal dendritic cells characterized high β8-integrin expression, leading to induce Tregs through induction of active-form of TGF-β mediated by those DCs.
Our results demonstrated that Japanese traditional fermented foods such as "Funazushi" are valuable source for probiotics that has strong anti-inflammatory effects compared to conventional type of probiotics.
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