| Project/Area Number |
23590959
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Gunma University |
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Principal Investigator |
Sato Ken 群馬大学, 医学部附属病院, 助教 (40396619)
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| Co-Investigator(Kenkyū-buntansha) |
山崎 勇一 群馬大学, 医学(系)研究科(研究院), 助教 (00582404)
堀口 昇男 群馬大学, 医学部附属病院, 助教 (10550022)
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| Co-Investigator(Renkei-kenkyūsha) |
SATOH tetsurou 群馬大学, 医学部附属病院, 講師 (40302484)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 脂質 / 病理学 / 発現制御 / 遺伝子 / 動物 |
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| Outline of Final Research Achievements |
Methionine-choline-deficient diet (MCD diet) has been established to use to make an animal model of non-alchoholic steatohepatitis. In PPAR gamma DNA-binding domain-interacting protein1 (PDIP1) knockout mice, serum ALT and TG, and hepatic fatty deposition, inflammation, and fibrosis were significantly reduced compared to wild type mice. Besides, the expressions of hepatic lipid-related genes have changed and hepatic inflammatory cytokines and fibrogenic genes were significantly reduced compared to wild type mice. Thus, we showed that non-alchoholic steatohepatitis was ameliorated in PDIP1 knockout mice.
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