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Identification of a histone modifier regulating hepatocarcinogenesis

Research Project

Project/Area Number 23590962
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Gastroenterology
Research InstitutionThe University of Tokyo

Principal Investigator

SHIINA Shuichiro  東京大学, 医学部附属病院, 臨床登録医 (70251238)

Co-Investigator(Kenkyū-buntansha) TATEISHI Keisuke  東京大学, 医学部附属病院, 講師 (20396948)
ASAOKA Yoshinari  東京大学, 医学部附属病院, 助教 (90431858)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords肝がん / ヒストン修飾 / 肝癌
Research Abstract

We established the Alb-Cre/PIK3CA-TG mice that showed hepatic fat deposition at 12w after birth and developed liver tumors including hepatocellular carcinoma by 52w. The PI3K activity was enhanced and tumor suppressor genes including PTEN, ARID3B, XPO4 and DLC1 were downregulated in the tumors. The tumors included a high amount of fatty acids, especially oleic acids. We showed that oleic acids exacerbate the colony formation of immortalized liver cells and reduce the expression of tumor suppressors described above. Furthermore, we have found a chromatin regulator that regulates the tumor formation of Alb-Cre/PIK3CA-TG mice.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (52 results)

All 2014 2013 2012 2011

All Journal Article (33 results) (of which Peer Reviewed: 21 results) Presentation (19 results)

  • [Journal Article] IL28B minor allele is associated with a younger age of onset of hepatocellular carcinoma in patients with chronic hepatitis C virus infection2014

    • Author(s)
      Sato M, Kato N, Tateishi R, Muroyama R, Kowatari N, Li W, Goto K, Otsuka M, Shiina S, Yoshida H, Omata M, Koike K
    • Journal Title

      J Gastroenterol

      Volume: 49(4) Issue: 4 Pages: 748-54

    • DOI

      10.1007/s00535-013-0826-x

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Impact of PNPLA3 polymorphisms on the development of hepatocellular carcinoma in patients with chronic hepatitis C virus infection.2013

    • Author(s)
      Sato M, Kato N, Tateishi R, Muroyama R, Kowatari N, Li W, Goto K, Otsuka M, Shiina S, Yoshida H, Omata M, Koike K.
    • Journal Title

      Hepatol Res.

      Volume: : Issue: 10

    • DOI

      10.1111/hepr.12258

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Changes in Risk of Immediate Adverse Reactions to Iodinated Contrast Media by Repeated Administrations in Patients with Hepatocellular Carcinoma2013

    • Author(s)
      Fujiwara N, Tateishi R, Akahane M, Taguri M, Minami T, Mikami S, Sato M, Uchino K, Enooku K, Kondo Y, Asaoka Y, Yamashiki N, Goto T, Shiina S, Yoshida H, Ohtomo K, Koike K.
    • Journal Title

      PLoS One

      Volume: 8 Issue: 10 Pages: e76018-e76018

    • DOI

      10.1371/journal.pone.0076018

    • URL

      https://pure.teikyo.jp/en/publications/66474794-4ea2-4654-902d-8135db1d42a4

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Spontaneous clearance of serum hepatitis C virus RNA during the clinical course of hepatocellular carcinoma in patients with chronic hepatitis C.2013

    • Author(s)
      Minami T, Tateishi R, Shiina S, Fujiwara N, Mikami S, Sato M, Uchino K, Enooku K, Asaoka Y, Kondo Y, Yoshida H, Koike K.
    • Journal Title

      Hepatol Res.

      Volume: : Issue: 10

    • DOI

      10.1111/hepr.12203

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] CT with hepatic arterioportography as a pretreatment examination for hepatocellular carcinoma patients : a randomized controlled trial2013

    • Author(s)
      Ohki T, Tateishi R, Akahane M, Mikami S, Sato M, Uchino K, Arano T, Enooku K, Kondo Y, Yamashiki N, Goto T, Shiina S, Yoshida H, Matsuyama Y, Omata M, Ohtomo K, Koike K
    • Journal Title

      Am JGastroenterol

      Volume: 108(8) Issue: 8 Pages: 1305-13

    • DOI

      10.1038/ajg.2013.109

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Radiofrequency ablation for colorectal liver metastasis : 10-year outcome and future perspective2013

    • Author(s)
      Shiina S, Sato T, Kondo Y, Asaoka Y, Tateishi R, Koike K
    • Journal Title

      Nihon Geka Gakkai Zasshi

      Volume: 114(2) Pages: 107-11

    • NAID

      110009596725

    • Related Report
      2013 Final Research Report
  • [Journal Article] Frequency, Risk Factors and Survival Associated with an Intrasubsegmental Recurrence after Radiofrequency Ablation for Hepatocellular Carcinoma2013

    • Author(s)
      Tateishi R, Shiina S, Akahane M, Sato J, Kondo Y, Masuzaki R, Nakagawa H, Asaoka Y, Goto T, Otomo K, Omata M, Yoshida H, Koike K.
    • Journal Title

      PLoS One

      Volume: 8 Issue: 4 Pages: e59040-e59040

    • DOI

      10.1371/journal.pone.0059040

    • URL

      https://pure.teikyo.jp/en/publications/feac7d4b-6c70-4491-ae22-3a0e992e0837

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Clinical characteristics of patients who developed hepatocellular carcinoma after hepatitis C virus eradication with interferon therapy: current status in Japan.2013

    • Author(s)
      Sato A, Sata M, Ikeda K, Kumada T, Izumi N, Asahina Y, Osaki Y, Chayama K, Kaneko S, Sakai A, Onji M, Hiasa Y, Omura T, Ozeki I, Yokosuka O, Shiina S, Itsubo M, Nishiguchi S, Hirano K, Ide T, Sakisaka S, Yamasaki T, Hidaka I, Tanaka M, Kim SR, Ichida T.
    • Journal Title

      Intern Med

      Volume: 52 Pages: 2701-6

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] IL28B minor allele is associated with a younger age of onset of hepatocellular carcinoma in patients with chronic hepatitis C virus infection.2013

    • Author(s)
      Sato M, Kato N, Tateishi R, Muroyama R, Kowatari N, Li W, Goto K, Otsuka M, Shiina S, Yoshida H, Omata M, Koike K.
    • Journal Title

      J Gastroenterol.

      Volume: :

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] CT with hepatic arterioportography as a pretreatment examination for hepatocellular carcinoma patients: a randomized controlled trial.2013

    • Author(s)
      Ohki T, Tateishi R, Akahane M, Mikami S, Sato M, Uchino K, Arano T, Enooku K, Kondo Y, Yamashiki N, Goto T, Shiina S, Yoshida H, Matsuyama Y, Omata M, Ohtomo K, Koike K.
    • Journal Title

      Am J Gastroenterol.

      Volume: 108 Pages: 1305-13

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Radiofrequency ablation for colorectal liver metastasis: 10-year outcome and future perspective.2013

    • Author(s)
      Shiina S, Sato T, Kondo Y, Asaoka Y, Tateishi R, Koike K.
    • Journal Title

      Nihon Geka Gakkai Zasshi

      Volume: 114 Pages: 107-11

    • NAID

      110009596725

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] IGF-II producing hepatocellular carcinoma treated with sorafenib: Metabolic complications and a foresight to molecular targeting therapy to the IGF signal2012

    • Author(s)
      Okushin K, Asaoka Y, Fukuda I,Fujiwara N, Minami T, Sato M, Mikami S,Uchino K, Enooku K, Kondo Y, Tateishi R, Goto T, Shiina S, Yoshida H, Koike K.
    • Journal Title

      Case Rep Gastroenterol

      Volume: 6 Issue: 3 Pages: 784

    • DOI

      10.1159/000346462

    • URL

      https://pure.teikyo.jp/en/publications/5c9148c4-91ae-4e11-b87f-ee51b8626a51

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Computed tomography follow-up for the detection of hepatocellular carcinoma recurrence after initial radiofrequency ablation: A single-center experience2012

    • Author(s)
      Mikami S, Tateishi R, Akahane M, Asaoka Y, Kondo Y, Goto T, Shiina S, Yoshida H, Koike K
    • Journal Title

      J Vasc Interv Radiol

      Volume: 23 Issue: 10 Pages: 1269

    • DOI

      10.1016/j.jvir.2012.06.032

    • URL

      https://pure.teikyo.jp/en/publications/6617a165-90b4-4c4f-ab1d-b1cbe6ccbaa2

    • Related Report
      2013 Final Research Report
  • [Journal Article] Percutaneous ethanol injection for hepatocellular carcinoma: class FormattedString { value: 20-year outcome and prognostic factors }2012

    • Author(s)
      Shiina S, Tateishi R, Imamura M, Teratani T, Koike Y, Sato S, Obi S, Kanai F, Kato N, Yoshida H, Omata M, Koike K
    • Journal Title

      Liver Int

      Volume: 32 Issue: 9 Pages: 1434

    • DOI

      10.1111/j.1478-3231.2012.02838.x

    • URL

      https://localhost/en/publications/1184d6a6-b933-47dd-875f-affceded4f69

    • Related Report
      2013 Final Research Report
  • [Journal Article] Tumor markers for hepatocellular carcinoma2012

    • Author(s)
      Tateishi R, Enooku K, Shiina S, Koike K
    • Journal Title

      Nihon Rinsho

      Volume: 70(5) Pages: 821-7

    • NAID

      40019297771

    • Related Report
      2013 Final Research Report
  • [Journal Article] Increased activity of serum mitochondrial isoenzyme of creatine kinase in hepatocellular carcinoma patients predominantly with recurrence2012

    • Author(s)
      Soroida Y, Ohkawa R, Nakagawa H, Satoh Y, Yoshida H, Kinoshita H, Tateishi R, Masuzaki R, Enooku K, Shiina S, Sato T, Obi S, Hoshino T, Nagatomo R, Okubo S, Yokota H, Koike K, Yatomi Y, Ikeda H
    • Journal Title

      J Hepatol

      Volume: 57 Issue: 2 Pages: 330

    • DOI

      10.1016/j.jhep.2012.03.012

    • URL

      https://localhost/en/publications/e50e0b1d-a2f2-443b-a645-c1ce56b2e143

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Assessment of disease progression in patients with transfusion-associated chronic hepatitis C using transient elastography2012

    • Author(s)
      Masuzaki R, Tateishi R, Yoshida H, Arano T, Uchino K, Enooku K, Goto E, Nakagawa H, Asaoka Y, Kondo Y, Goto T, Ikeda H, Shiina S, Omata M, Koike K
    • Journal Title

      World J Gastroenterol

      Volume: 18 Issue: 12 Pages: 1385

    • DOI

      10.3748/wjg.v18.i12.1385

    • URL

      https://localhost/en/publications/70a14a29-f228-4b62-a358-ed235e5b682c

    • Related Report
      2013 Final Research Report
  • [Journal Article] Systemic combination therapy of intravenous continuous 5-fluorouracil and subcutaneous pegylated interferon alfa-2a for advanced hepatocellular carcinoma2012

    • Author(s)
      Kondo Y et al. (19人中13番目)
    • Journal Title

      J Gastroenterol.

      Volume: 47 Issue: 10 Pages: 1152

    • DOI

      10.1007/s00535-012-0574-3

    • NAID

      10031122104

    • URL

      https://pure.teikyo.jp/en/publications/44531dd1-23ee-4f24-b5cd-93274dc67a2d

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Value of post-vascular phase (Kupffer imaging) by contrast-enhanced ultrasonography using Sonazoid in the detection of hepatocellular carcinoma.2012

    • Author(s)
      Goto T et al. (12人中6番目)
    • Journal Title

      J Gastroenterol.

      Volume: 47 Issue: 4 Pages: 477-85

    • DOI

      10.1007/s00535-011-0512-9

    • NAID

      10030650324

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Radiofrequency ablation for hepatocellular carcinoma: 10-year outcome and prognostic factors.2012

    • Author(s)
      Kondo Y et al. (14人中10番目)
    • Journal Title

      Am J Gastroenterol.

      Volume: 107 Issue: 4 Pages: 569-77

    • DOI

      10.1038/ajg.2011.425

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of molecular targeted cancer drug by changes in tumor marker doubling times.2012

    • Author(s)
      Kondo Y et al. (10人中4番目)
    • Journal Title

      J Gastroenterol.

      Volume: 47 Issue: 1 Pages: 71-8

    • DOI

      10.1007/s00535-011-0462-2

    • NAID

      10030295766

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Percutaneous ethanol injection for hepatocellular carcinoma: 20-year outcome and prognostic factors.2012

    • Author(s)
      Shiina S, Tateishi R, Imamura M, Teratani T, Koike Y, Sato S, Obi S, Kanai F, Kato N, Yoshida H, Omata M, Koike K.
    • Journal Title

      Liver Int

      Volume: 32 Pages: 1434-42

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Radiofrequency ablation for hepatocellular carcinoma: 10-year outcome and prognostic factors.2012

    • Author(s)
      Shiina S, Tateishi R, Arano T, Uchino K, Enooku K, Nakagawa H, Asaoka Y, Sato T, Masuzaki R, Kondo Y, Goto T, Yoshida H, Omata M, Koike K.
    • Journal Title

      Am J Gastroenterol.

      Volume: 107 Pages: 569-77

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Characteristics of hepatocellular carcinoma nodules newly detected by computed tomography during arteriography and arterial portography : preliminary report of a randomized controlled trial2011

    • Author(s)
      Ohki T, Tateishi R, Akahane M, Shiina S, Yamashiki N, Mikami S, Enooku K, Goto E, Masuzaki R, Kondo Y, Goto T, Inoo S, Ohtomo K, Omata M, Yoshida H, Koike K
    • Journal Title

      Hepatol Int

    • Related Report
      2013 Final Research Report
  • [Journal Article] Prediction of hepatocellular carcinoma development by plasma ADAMTS 13 in chronic hepatitis B and C2011

    • Author(s)
      Ikeda H, Tateishi R, Enooku K, Yoshida H, nakagawa H, Masuzaki R, Kondo Y, Goto T, Shiina S, Kume Y, Tomiya T, Inoue Y, Nishikawa T, Ohtomo N, Tanoue Y, Ono T, Koike K, Yatomi Y
    • Journal Title

      Cancer Epidemiol Biomarkers Prev.

      Volume: 20 Issue: 10 Pages: 2204-11

    • DOI

      10.1158/1055-9965.epi-11-0464

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] HCC Expert Panel of Japan Society of Hepatology. Management of hepatocellular carcinoma in Japan : Consensus-Based Clinical Practice Guidelines proposed by the Japan Society of Hepatology (JSH) 2010 updated version2011

    • Author(s)
      Kudo M, Izumi N, Kokudo N, Matsui O, Sakamoto M, Nakashima O, Kojiro M, Makuuchi M
    • Journal Title

      Dig Dis

      Volume: 29(3) Issue: 3 Pages: 339-64

    • DOI

      10.1159/000327577

    • Related Report
      2013 Final Research Report
  • [Journal Article] Altered composition of fatty acids exacerbates hepatotumorigenesis during activation of the phosphatidylinositol 3-kinase pathway2011

    • Author(s)
      Kudo Y, Tanaka Y, Tateishi K, Yamamoto K, Yamamoto S, Mohri D, Isomura Y, Seto M, Nakagawa H, Asaoka Y, Tada M, Ohta M, Ijichi H, Hirata Y, Otsuka M, Ikenoue T, Maeda S, Shiina S, Yoshida H, Nakajima O, Kanai F, Omata M, Koike K
    • Journal Title

      J Hepatol

      Volume: 55(6) Pages: 1400-8

    • Related Report
      2013 Final Research Report
  • [Journal Article] Direct differentiation of hepatic cells from human induced pluripotent stem cells using a limited number of cytokines2011

    • Author(s)
      Takata A, Otsuka M, Kogiso T, Kojima K, Yoshikawa T, Tateishi R, Kato N, Shiina S, Yoshida H, Omata M, Koike K
    • Journal Title

      Hepatol Int

    • Related Report
      2013 Final Research Report
  • [Journal Article] Influence of serum HBV DNA load on recurrence of hepatocellular carcinoma after treatment with percutaneous radiofrequency ablation2011

    • Author(s)
      Goto T, Yoshida H, Tateishi R, Enooku K, Goto E, Sato T, Ohki T, Masuzaki R, Imamura J, Shiina S, Koike K, Omata M
    • Journal Title

      Hepatol Int

      Volume: 5 Issue: 3 Pages: 767

    • DOI

      10.1007/s12072-011-9255-1

    • URL

      https://pure.teikyo.jp/en/publications/08a6126a-c242-45cf-ae20-b155430cdc0f

    • Related Report
      2013 Final Research Report
  • [Journal Article] Hepatocellular carcinoma with extrahepatic metastasis : clinical features and prognostic factors2011

    • Author(s)
      Uchino K, Tateishi R, Shiina S, Kanda M, Masuzaki R, Kondo Y, Goto T, Omata M, Yoshida H, Koike K
    • Journal Title

      Cancer

      Volume: 117(19) Issue: 19 Pages: 4475-83

    • DOI

      10.1002/cncr.25960

    • Related Report
      2013 Final Research Report
  • [Journal Article] Serum level of adiponectin and the risk of liver cancer development in chronic hepatitis C patients.2011

    • Author(s)
      Arano T, Nakagawa H, Tateishi R, Ikeda H, Uchino K, Enooku K, Goto E, Masuzaki R, Asaoka Y, Kondo Y, Goto T, Shiina S, Omata M, Yoshida H, Koike K.
    • Journal Title

      Int J Cancer

      Volume: 129(9) Issue: 9 Pages: 2226-35

    • DOI

      10.1002/ijc.25861

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Intrahepatic bile duct dilatation after percutaneous radiofrequency ablation for hepatocellular carcinoma: class FormattedString { value: Impact on patient's prognosis }2011

    • Author(s)
      Kondo Y, Shiina S, Tateishi R, Arano T, Uchino K, Enooku K, Goto E, Nakagawa H, Masuzaki R, Asaoka Y, Fujie H, Goto T, Omata M, Yoshida H, Koike K.
    • Journal Title

      Liver Int

      Volume: 31 Issue: 2 Pages: 197

    • DOI

      10.1111/j.1478-3231.2010.02415.x

    • URL

      https://localhost/en/publications/365962d2-a2b7-4dc1-bba4-47ae5bfef167

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Utility of contrast-enhanced ultrasonography with Sonazoid in radiofrequency ablation for hepatocellular carcinoma2011

    • Author(s)
      Masuzaki R, Shiina S, Tateishi R, Yoshida H, Goto E, Sugioka Y, Kondo Y, Goto T, Ikeda H, Omata M, Koike K
    • Journal Title

      J Gastroenterol Hepatol

      Volume: 26(4) Issue: 4 Pages: 759-64

    • DOI

      10.1111/j.1440-1746.2010.06559.x

    • Related Report
      2013 Final Research Report
  • [Presentation] ヒストン修飾酵素JHDM3CはWnt-Notchシグナルのメデイエーターとして大腸腫瘍形成能を制御する2013

    • Author(s)
      山本信三、立石敬介、工藤洋太郎、山本恵介、砂河孝行、永江玄太、中塚拓馬、浅岡良成、伊地知秀明、小俣政男、油谷浩幸、小池和彦
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2013-10-04
    • Related Report
      2013 Final Research Report
  • [Presentation] KDM4C regulates sphere formation by mediating the crosstalk between Wnt and Notch pathways in colonic cancer cells2013

    • Author(s)
      山本信三、立石敬介、工藤洋太郎、山本恵介、砂河孝行、永江玄太、油谷浩幸、小池和彦
    • Organizer
      Cell symposia
    • Place of Presentation
      Spain
    • Related Report
      2013 Final Research Report
  • [Presentation] Contribution of TET1 to malignant characteristics in digestive cancer cells2013

    • Author(s)
      工藤洋太郎、立石敬介、池上恒雄、山本恵介、永江玄太、米澤理人、関元昭、白井、油谷浩幸、小池和彦
    • Organizer
      Cell symposia
    • Place of Presentation
      Spain
    • Related Report
      2013 Final Research Report
  • [Presentation] 膵発癌モデルマウスを用いたゲムシタビンとエルロチニブの効果・メカニズムの検討膵癌:基礎研究2012

    • Author(s)
      宮林弘至,伊地知秀明,毛利大,多田素久,山本恵介,浅岡良成,池上恒雄,立石敬介,中井陽介,伊佐山浩通,多田稔,小池和彦
    • Organizer
      第43回日本膵臓学会大会
    • Place of Presentation
      山形
    • Year and Date
      2012-06-29
    • Related Report
      2013 Final Research Report
  • [Presentation] 悪性形質転換におけるヒドロキシメチル化シトシンの低下2012

    • Author(s)
      工藤洋太郎,立石敬介,山本恵介,山本信三,浅岡良成,伊地知秀明,永江玄太,油谷浩幸,小池和彦
    • Organizer
      第6回日本エピジェネティクス研究会年会
    • Place of Presentation
      東京(ポスター討論)
    • Year and Date
      2012-05-15
    • Related Report
      2013 Final Research Report
  • [Presentation] 大腸癌肝転移に対するラジオ波焼灼術(RFA)10年間の成績と今後の展開2012

    • Author(s)
      椎名秀一朗
    • Organizer
      第67回日本大腸肛門病学会学術総会
    • Place of Presentation
      福岡
    • Related Report
      2013 Final Research Report
  • [Presentation] Multimodality fusing imagingを用いた経皮的ラジオ波焼灼術(RFA)2012

    • Author(s)
      椎名秀一朗、金井弓美子、南達也、佐藤雅哉、三神信太郎、内野康志、新野徹、榎奥健一郎、近藤祐嗣、浅岡良成、建石良介、後藤忠、吉田晴彦、佐藤隆久、小池和彦
    • Organizer
      第48回日本肝癌研究会
    • Place of Presentation
      金沢
    • Related Report
      2013 Final Research Report
  • [Presentation] 大腸癌肝転移に対するラジオ波焼灼術(RFA)10年間の成績と今後の展開2012

    • Author(s)
      椎名秀一朗
    • Organizer
      第48回日本肝癌研究会
    • Place of Presentation
      福岡
    • Related Report
      2013 Final Research Report
  • [Presentation] Pancreatic ductal adenocarcinoma can arise from Nestin- positive progenitor cells in the adult pancreas2012

    • Author(s)
      伊地知秀明、宮林功至、多田素久、浅岡良成、池上恒雄、立石敬介、小俣政男、小池和彦
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      札幌
    • Related Report
      2013 Final Research Report
  • [Presentation] Loss of 5-hydroxymethylcytosine is accompanied with malignant cellular transformation2012

    • Author(s)
      工藤洋太郎、立石敬介、山本恵介、山本信三、浅岡良成、伊地知秀明、永江玄太、油谷浩幸、小池和彦
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      札幌
    • Related Report
      2013 Final Research Report
  • [Presentation] multimodality fusion imagingを用いた経皮的ラジオ波焼灼術2012

    • Author(s)
      椎名秀一朗、小池和彦
    • Organizer
      第48回日本肝癌研究会
    • Place of Presentation
      金沢
    • Related Report
      2012 Research-status Report
  • [Presentation] 大腸癌肝転移に対するラジオ波焼灼術 10年間の成績と今後の展開2012

    • Author(s)
      椎名秀一朗、小池和彦
    • Organizer
      第48回日本肝臓学会総会
    • Place of Presentation
      金沢
    • Related Report
      2012 Research-status Report
  • [Presentation] Hippoシグナル異常を伴う肝細胞癌における受容体型チロシンキナーゼに関する検討2011

    • Author(s)
      浅岡良成,池上恒雄,多田素久,建石良介,伊地知秀明,立石敬介,金井文彦,椎名秀一朗,吉田晴彦,小俣政男,小池和彦
    • Organizer
      第19回JDDW/第15回日本肝臓学会大会
    • Place of Presentation
      福岡
    • Year and Date
      2011-10-20
    • Related Report
      2013 Final Research Report
  • [Presentation] 膵癌微小環境におけるCXCケモカイン/CXCR2 Axis阻害の重要性Intercellular Interaction and Tumor Microenvironment2011

    • Author(s)
      伊地知秀明,多田素久,宮林弘至,浅岡良成,立石敬介,池上恒雄,小俣政男,小池和彦
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-10-03
    • Related Report
      2013 Final Research Report
  • [Presentation] 肝細胞癌におけるHippoシグナルの異常に関する検討肝発癌研究の新展開2011

    • Author(s)
      浅岡良成,池上恒雄,多田素久,後藤絵理子,建石良介,伊地知秀明,立石敬介,金井文彦,椎名秀一朗,吉田晴彦,小俣政男,小池和彦
    • Organizer
      第47回日本肝臓学会総会
    • Place of Presentation
      東京
    • Year and Date
      2011-06-03
    • Related Report
      2013 Final Research Report
  • [Presentation] 肝細胞癌(HCC)に対するラジオ波焼灼術(RFA)10年間の成績2011

    • Author(s)
      椎名秀一朗、建石良介、小池和彦
    • Organizer
      第47回日本肝癌研究会
    • Place of Presentation
      静岡
    • Related Report
      2013 Final Research Report
  • [Presentation] 大腸癌肝転移に対するラジオ波焼灼術(RFA)10年間の治療成績と今後の展望2011

    • Author(s)
      椎名秀一朗、建石良介、小池和彦
    • Organizer
      第47回日本肝臓学会総会
    • Place of Presentation
      東京
    • Related Report
      2013 Final Research Report
  • [Presentation] 大腸癌肝転移に対するラジオ波焼灼術(RFA)10年の成績2011

    • Author(s)
      椎名秀一朗、建石良介、小池和
    • Organizer
      第19回日本消化器病関連学会週間
    • Place of Presentation
      東京
    • Related Report
      2013 Final Research Report
  • [Presentation] ヒストン脱メチル化酵素JMJD3の発現低下は膵癌の進展を促進するエピジェネティクスと消化器癌2011

    • Author(s)
      山本恵介,立石敬介,宮林弘至,山本信三,工藤洋太郎,浅岡良成,伊地知秀明,小俣政男,小池和彦
    • Organizer
      第19回JDDW
    • Place of Presentation
      福岡
    • Related Report
      2013 Final Research Report

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Published: 2011-08-05   Modified: 2019-07-29  

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