Whole Exome Analysis of EpCAM-positive Hepatocellular Carcinoma Stem Cells
Project/Area Number |
23590967
|
Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Gastroenterology
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Research Institution | Kanazawa University |
Principal Investigator |
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Project Period (FY) |
2011 – 2013
|
Project Status |
Completed (Fiscal Year 2013)
|
Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
|
Keywords | 肝細胞癌 / 癌幹細胞 |
Research Abstract |
Recent evidences suggest that hepatocellular carcinoma possesses cancer stem cells that play a pivotal role on local recurrence and distant organ metastasis after radical treatment. In this study, we evaluated the genetic mutations observed in hepatocellular carcinoma containing EpCAM-positive cancer stem cells at whole exome level. We identified TP53, ARID, and CDKN mutations in EpCAM-positive hepatocellular carcinoma cells. These mutations may be responsible for the maintenance of EpCAM-positive cancer stem cells and therefore may be good targets for eradication of hepatocellular carcinoma.
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Report
(4 results)
Research Products
(27 results)
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[Journal Article] The transcription factor SALL4 regulates stemness of EpCAM-positive hepatocellular carcinoma2014
Author(s)
Zeng SS, Yamashita T, Kondo M, Nio K, Hayashi T, Hara Y, Nomura Y, Yoshida M, Hayashi T, Oishi N, Ikeda H, Honda M, and Kaneko S
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Journal Title
J Hepatol
Volume: (60)
Pages: 127-34
NAID
Related Report
Peer Reviewed
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[Journal Article] The transcription factor SALL4 regulates stemness of EpCAM-positive hepatocellular carcinoma.2014
Author(s)
Zeng SS, Yamashita T, Kondo M, Nio K, Hayashi T, Hara Y, Nomura Y, Yoshida M, Hayashi T, Oishi N, Ikeda H, Honda M, and Kaneko S.
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Journal Title
Journal of Hepatology
Volume: 60
Issue: 1
Pages: 127-134
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] Discrete Nature of EpCAM+ and CD90+ Cancer Stem Cells in Human Liver Cancer2013
Author(s)
Yamashita T, Honda M, Nakamoto Y, Baba M, Nio K, Hara Y, Zeng SS, Hayashi T, Kondo M, Takatori H, Yamashita T, Mizukoshi E, Ikeda H, Zen Y, Takamura H, Wang XW, and Kaneko S
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Journal Title
Hepatology
Volume: (57)
Pages: 1484-97
Related Report
Peer Reviewed
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[Journal Article] Transcriptomic profiling reveals hepatic stem-like gene signatures and interplay of miR-200c and epithelial-mesenchymal transition in intrahepatic cholangiocarcinoma2012
Author(s)
Oishi N, Kumar MR, Roessler S, Ji J, Forgues M, Budhu A, Zhao X, Andersen JB, Ye QH, Jia HL, Qin LX, Yamashita T, Woo HG, Kim YJ, Kaneko S, Tang ZY, Thorgeirsson SS, and Wang XW
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Journal Title
Hepatology
Volume: (56)
Pages: 1792-803
Related Report
Peer Reviewed
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[Journal Article] Nucleostemin in ijury induced liver regeneration2012
Author(s)
Shugo H, Ooshio T, Naito M, Naka K, Hoshii T, Tadokoro Y, Muraguchi T, Tamase A, Uema N, Yamashita T, Nakamoto Y, Suda T, Kaneko S, and Hirao A
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Journal Title
Stem Cells Dev
Volume: (21)
Pages: 3044-54
Related Report
Peer Reviewed
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[Presentation] Gd-EOB-DTPA-enhanced MRI and Serum AFP Predict the Prognosis of Early-stage Hepatocellular Carcinoma2013
Author(s)
Yamashita T, Kitao A, Matsui O, Hayashi T, Nio K, Kondo M, Okada H, Yamashita T, Mizukoshi E, Honda M, Nakanuma Y, Takamura H, Ohta T, Nakamoto Y, Yamamoto M, Takayama T, Arii S, Wang XW, and Kaneko S
Organizer
AASLD Annual Meeting
Place of Presentation
Washington DC
Year and Date
2013-11-05
Related Report
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[Presentation] The evolution of diverse cancer stem cells in human liver cancer2013
Author(s)
Yamashita T, Honda M, Nio K, Hara Y, Hayashi T, Oishi N, Sunakozaka H, Takatori H, Colombo F, Porretti L, Wang XW, and Kaneko S
Organizer
AACR Annual Meeting
Place of Presentation
Washington DC
Year and Date
2013-04-07
Related Report
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[Presentation] The evolution of diverse cancer stem cells in human liver cancer2012
Author(s)
Yamashita T, Honda M, Nakamoto Y, Nio K, Hara Y, Zeng SS, Hayashi T, Yamashita T, Mizukoshi E, Ikeda H, Zen Y, Takamura H, Colombo F, Porretti L, Wang XW, and Kaneko S
Organizer
AASLD Annual Meeting
Place of Presentation
Boston
Year and Date
2012-11-10
Related Report
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[Presentation] 肝細胞癌の分子分類2012
Author(s)
山下太郎、本多政夫、金子周一
Organizer
日本肝癌研究会、教育基調シンポジウム
Place of Presentation
金沢
Year and Date
2012-07-20
Related Report
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[Presentation] The evolution of diverse cancer stem cells in human liver cancer.2012
Author(s)
Yamashita T, Honda M, Nakamoto Y, Nio K, Hara Y, Zeng SS, Hayashi T, Yamashita T, Mizukoshi E, Ikeda H, Zen Y, Takamura H, Colombo F, Porretti L, Wang XW, and Kaneko S.
Organizer
American Association of Study of Liver Diseases Annual Meeting
Place of Presentation
Hynes Convention Center (U.S.A.)
Related Report
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[Presentation] Distinct liver cancer stem cells defined by EpCAM and CD90 in human hepatocellular carcinoma.2011
Author(s)
Yamashita T, Honda M, Nakamoto Y, Mizukoshi E, Yamashita T, Arai K, Nio K, Hara Y, Wang XW, and Kaneko S.
Organizer
American Association of Study of Liver Diseases (AASLD)Annual Meeting
Place of Presentation
Hynes Convention Center, Boston
Related Report
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[Presentation] The evolution of diverse cancer stem cells in human liver cancer.
Author(s)
Yamashita T, Honda M, Nio K, Hara Y, Hayashi T, Oishi N, Sunakozaka H, Takatori H, Colombo F, Porretti L, Wang XW, and Kaneko S.
Organizer
AACR Annual Meeting
Place of Presentation
Walter E. Washington Convention Center (Washington DC, U.S.A.)
Related Report
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[Presentation] Biomarkers of cancer stem cells in HCC.
Author(s)
Yamashita T, Honda M, Kaneko S.
Organizer
The 1st International Symposium of Catholic Liver Research Center
Place of Presentation
1002 hall, Institute of Biomedical Industry, The Catholic University (Seoul, Korea)
Related Report
Invited
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