| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Research Abstract |
We investigated HLA class I A, B, and C and HLA class II DRB1 and DQB1 alleles and haplotypes in Japanese patients with autoimmune hepatitis (AIH) and primary biliary cirrhosis (PBC). HLA-DRB1 DRB1*04:05-DQB1*04:01 haplotype was significantly associated with AIH susceptibility. Conversely, the DRB1*15:01-DQB1*06:02 haplotype was associated with protection from both disease onset. Significant associations were found with PBC susceptibility for the DRB1*08:03-DQB1*06:01. There were significant protective associations with the DRB1*13:02-DQB1*06:04 and DRB1*11:01-DQB1*03:01 haplotypes. The frequency of the DRB1*08:03-DQB1*06:01 haplotype was significantly higher in AIH patients who developed hepatic failure. The frequency of the DRB1*09:01-DQB1*03:03 haplotype was significantly higher in PBC patients who had received orthotopic liver transplantation. We established the role of HLA haplotypes in determining AIH and PBC susceptibility, protection and progression in the Japanese population.
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