Identification of Gab1 as a novel therapeutic target for hepatocellular carcinoma

• Project/Area Number: 23590974
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Osaka University
• Principal Investigator: YOSHIDA YUICHI 大阪大学, 医学(系)研究科(研究院), 助教 (30457014)
• Co-Investigator(Kenkyū-buntansha): KISO Shinichi 大阪大学, 医学系研究科, 特任准教授 (40335352) ; WATABE Kenji 大阪大学, 医学系研究科, 助教 (50379244) ; 筒井 秀作 大阪大学, 医学(系)研究科(研究院), 助教 (10359846)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2011: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
• Keywords: 肝発癌 / シグナル伝達 / Gab1 / 分子標的治療 / 肝細胞癌 / 肝線維化 / CCL5 / MAP kinase

Research Abstract

Recently, a better understanding of molecular pathogenesis regarding hepatocellular carcinoma (HCC), including growth factor or receptor Tyrosine Kinases (RTKs) signaling, has led to the development of the novel molecular target therapy. Grb2-associated binder Gab1 is a scaffolding docking adaptor that amplifies signals downstream of a broad range of growth factors/receptor tyrosine kinases, such as HGF/c-MET- or HB-EGF/EGFR- signaling pathways. Although these signals are implicated in liver carcinogenesis, the roles of Gab1 remain unclear. Here, we investigated the role of Gab1 in HCC and demonstrated that Gab1 regulates the proliferation of HCC cells in vitro and in vivo. Furthermore, hepatocyte-specific deletion of Gab1 in mice resulted in the enhanced liver fibrosis, which is the major cause of HCC in human. Together, our current results indicate the crucial role of Gab1 in hepatocarcinogenesis and that Gab1 could be a novel molecular target for HCC.

Research Products

• [Journal Article] Lipid overloading during liver regeneration causes delayed hepatocyte DNA replication by increasing ER stress in mice with simple hepatic steatosis. (2014)
  • Author(s): Hamano M, Ezaki H, Kiso S, Furuta K, Egawa M, Kizu T, Chatani N, Kamada Y, Yoshida Y, Takehara T.
  • Journal Title: J Gastroenterol. Volume: 49 Issue: 2 Pages: 305-316
  • DOI: 10.1007/s00535-013-0780-7
  • Peer Reviewed / Open Access
• [Journal Article] Adiponectin negatively correlates with alcoholic and non-alcoholic liver dysfunction : Health check-up study of Japanese men (2013)
  • Author(s): Hamano M, Kiso S, Yoshida Y, Watabe K,他19人
  • Journal Title: Hepatol Res Volume: 43(3) Issue: 3 Pages: 238-48
  • DOI: 10.1111/j.1872-034x.2012.01066.x
  • NAID: 10031183465
  • Peer Reviewed
• [Journal Article] Pitavastatin ameliorated the progression of steatohepatitis in ovariectomized mice fed a high fat and high cholesterol diet. (2013)
  • Author(s): Kamada Y, Kiso S, Yoshida Y, Chatani N, Kizu T, Hamano M, Egawa M, Takemura T, Ezaki H, Furuta K, Hayashi N, Takehara T.
  • Journal Title: Hepatol Res. Volume: 43 Issue: 4 Pages: 401-412
  • DOI: 10.1111/j.1872-034x.2012.01082.x
  • NAID: 10031194552
  • Peer Reviewed
• [Journal Article] Serum Mac-2 binding protein levels as a novel diagnostic biomarker for prediction of disease severity and nonalcoholic steatohepatitis. (2013)
  • Author(s): Kamada Y, Fujii H,Miyoshi E,et.al.
  • Journal Title: Proteomics Clin Appl. Volume: 6 Issue: 9-10 Pages: 648-656
  • DOI: 10.1002/prca.201200137
  • Peer Reviewed
• [Journal Article] Serum fucosylated haptoglobin as a novel diagnostic biomarker for predicting hepatocyte ballooning and nonalcoholic steatohepatitis (2013)
  • Author(s): Kamada Y, Yoshida Y, Kiso S,他18人
  • Journal Title: PLoS One Volume: 8(6)
  • URL: http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0066328
  • Peer Reviewed
• [Journal Article] Conditional loss of heparin-binding EGF-like growth factor results in enhanced liver fibrosis after bile duct ligation in mice. (2013)
  • Author(s): Takemura T, Yoshida Y, Kiso S, Kizu T, Furuta K, Ezaki H, Hamano M, Egawa M, Chatani N, Kamada Y, Imai Y, Higashiyama S, Iwamoto R, Mekada E, Takehara T.
  • Journal Title: Biochem Biophys Res Commun. Volume: 437 Issue: 2 Pages: 185-191
  • DOI: 10.1016/j.bbrc.2013.05.097
  • Peer Reviewed
• [Journal Article] the Osaka Liver Forum. Post-treatment Levels ofα-fetoprotein Predict Incidence of Hepatocellular Carcinoma After Interferon Therapy (2013)
  • Author(s): Oze T, Yoshida Y,他25人
  • Journal Title: Clin Gastroenterol Hepatol Volume: (Epub ahead of print), (pii : S1542-3565(13)01840-5) Issue: 7 Pages: 1239-45
  • DOI: 10.1016/j.cgh.2013.11.033
  • Peer Reviewed
• [Journal Article] Serum fucosylated haptoglobin as a novel diagnostic biomarker for predicting hepatocyte ballooning and nonalcoholic steatohepatitis. (2013)
  • Author(s): Kamada Y, Akita M, Takeda Y, Yamada S, Fujii H, Sawai Y, Doi Y, Asazawa H, Nakayama K, Mizutani K, Fujii H, Yakushijin T, Miyazaki M, Ezaki H, Hiramatsu N, Yoshida Y, Kiso S, Imai Y, Kawada N, Takehara T, Miyoshi E.
  • Journal Title: PLoS One. Volume: 8 Issue: 6 Pages: e66328-e66328
  • DOI: 10.1371/journal.pone.0066328
  • Peer Reviewed
• [Journal Article] N-Acetylglucosaminyltransferase V regulates TGF- response in hepatic stellate cells and the progression of steatohepatitis. (2012)
  • Author(s): Kamada Y, Miyoshi E, et al.
  • Journal Title: Glycobiology Volume: 22(6) Issue: 6 Pages: 778-87
  • DOI: 10.1093/glycob/cws012
  • Peer Reviewed
• [Journal Article] Conditional knockout of heparin-binding epidermal growth factor-like growth factor in the liver accelerates carbon tetrachloride-induced liver injury in mice. (2012)
  • Author(s): Takemura, T., YoshidaY., Kiso, S., Saji, Y., Ezaki, H., Hamano, M., Kizu, T., Egawa, M., Chatani, N., Furuta, K., Kamada, Y., Iwamoto, R., Mekada, E., Higashiyama, S., Hayashi, N. and Takehara, T.
  • Journal Title: Hepatol Res Volume: 43 Issue: 4 Pages: 384-393
  • DOI: 10.1111/j.1872-034x.2012.01074.x
  • NAID: 10031194550
  • Peer Reviewed
• [Journal Article] Long-term effect of lamivudine treatment on the incidence of hepatocellular carcinoma in patients with hepatitis B virus infection. (2012)
  • Author(s): Kurokawa M, Hiramatsu N, Oze T, Yoshida Y, et al.
  • Journal Title: J Gastroenterol. Volume: 47 Issue: 5 Pages: 577-585
  • DOI: 10.1007/s00535-011-0522-7
  • NAID: 10030650709
  • Peer Reviewed
• [Journal Article] Reducing Peg-IFN doses causes later virologic response or no response in HCV genotype 1 patients treated with Peg-IFN alfa-2b plus ribavirin. (2012)
  • Author(s): Oze T, Hiramatsu N, Yoshida Y, et al.
  • Journal Title: J Gastroenterol. Volume: 47 Issue: 3 Pages: 334-342
  • DOI: 10.1007/s00535-011-0498-3
  • NAID: 10030560255
  • Peer Reviewed
• [Journal Article] Lower Serum Level of Adiponectin Is Associated with Increased Risk of Endoscopic Erosive Gastritis (2011)
  • Author(s): Yamamoto S, Watabe K, Kiso S, Yoshida Y,他14人
  • Journal Title: Dig Dis Sci Volume: 56(8) Issue: 8 Pages: 2354-60
  • DOI: 10.1007/s10620-011-1681-3
  • Peer Reviewed
• [Journal Article] Association of low serum adiponectin levels with erosive esophagitis in men : an analysis of 2405 subjects undergoing physical check-ups (2011)
  • Author(s): Kato M, Watabe K, Yoshida Y, Kiso S,他14人
  • Journal Title: J Gastroenterol Volume: 46(12) Issue: 12 Pages: 1361-7
  • DOI: 10.1007/s00535-011-0453-3
  • NAID: 10030295134
  • Peer Reviewed
• [Journal Article] Estrogen deficiency worsens steatohepatitis in mice fed high-fat and high-cholesterol diet (2011)
  • Author(s): Kamada Y, Kiso S, Yoshida Y,他8人
  • Journal Title: Am J Physiol Gastrointest Liver Physiol Volume: 301(6) Issue: 6 Pages: G1031-G1043
  • DOI: 10.1152/ajpgi.00211.2011
  • Peer Reviewed
• [Journal Article] Estrogen deficiency worsens steatohepatitis in mice fed high-fat and high-cholesterol diet. (2011)
  • Author(s): Kamada Y, Kiso S, Yoshida Y, Chatani N, Kizu T, Hamano M, Tsubakio M, Takemura T, Ezaki H, Hayashi N, Takehara T
  • Journal Title: Am J Physiol Gastrointest Liver Physiol. Volume: 301 Pages: 1031-1043
  • Peer Reviewed
• [Journal Article] Association of low serum adiponectin levels with erosive esophagitis in men: an analysis of 2405 subjects undergoing physical check-ups. (2011)
  • Author(s): Kato M, Watabe K, Yoshida Y, et al.
  • Journal Title: J Gastroenterol. Volume: 46 Issue: 7 Pages: 1361-1367
  • DOI: 10.1007/s00535-011-0403-0
  • NAID: 10030295134
  • Peer Reviewed
• [Journal Article] Indications and limitations for aged patients with chronic hepatitis C in pegylated interferon alfa-2b plus ribavirin combination therapy. (2011)
  • Author(s): Oze T, Hiramatsu N, Yoshida Y, et al.
  • Journal Title: J Hepatol. Volume: 54 Issue: 4 Pages: 604-611
  • DOI: 10.1016/j.jhep.2010.07.043
  • Peer Reviewed
• [Journal Article] Amino acid substitution in the core protein has no impact on relapse in hepatitis C genotype 1 patients treated with peginterferon and ribavirin (2011)
  • Author(s): Inoue Y, Tatsumi T, et al
  • Journal Title: Journal of Medical Virology Volume: 83 Issue: 3 Pages: 419-427
  • DOI: 10.1002/jmv.21975
  • Peer Reviewed
• [Journal Article] Efficacy of re-treatment with pegylated interferon plus ribavirin combination therpy for patients with chronic hepatitis C in Japan (2011)
  • Author(s): Oze T, Tatsumi T, et al
  • Journal Title: Journal of Gastroenterology Volume: 46 Issue: 8 Pages: 1031-1037
  • DOI: 10.1007/s00535-011-0409-7
  • Peer Reviewed
• [Presentation] Loss of Gab1 scaffolding adaptor protein in the hepatocytes exacerbates cholestasis-induced liver fibrosis in mice (2013)
  • Author(s): Takashi Kizu, Yuichi Yoshida, Kunimaro Furuta, Satoshi Ogura, Mayumi Egawa, Norihiro Chatani, Mina Hamano, Hisao Ezaki, Yoshihiro Kamada, Shinichi. Kiso, Tetsuo Takehara
  • Organizer: The 64th Annual Meeting of the American Association for the Study of Liver Diseases
  • Place of Presentation: Washington, DC, USA(ポスター発表)
  • Year and Date: 2013-11-04
• [Presentation] Kiso, Akihiko Shimano, Noriyuki Ouchi, Yuichi Yoshida, Tetsuo Takehara Lack of secreted frizzled-related protein 5 (Sfrp5), an adipocytokine, enhanced carbon-tetrachloride-induced liver fibrosis in mice (2013)
  • Author(s): Norihiro Chatani, Yoshihiro Kamada, Takashi Kizu, Satoshi Ogura, Kunimaro Furuta, Mayumi Egawa, Mina Hamano, Hisao Ezaki, Shinichi
  • Organizer: The 64th Annual Meeting of the American Association for the Study of Liver Diseases
  • Place of Presentation: Washington, DC, USA(ポスター発表)
  • Year and Date: 2013-11-04
• [Presentation] Kiso, Tetsuo Takehara Grb2-associated binder 1 docking protein is crucial for mortality in a mouse model of acute liver failure (2013)
  • Author(s): Kunimaro Furuta, Yuichi Yoshida, Takashi Kizu, Satoshi Ogura, Mayumi Egawa, Norihiro Chatani, Mina Hamano, Hisao Ezaki, Yoshihiro Kamada, Shinichi
  • Organizer: The 64th Annual Meeting of the American Association for the Study of Liver Diseases
  • Place of Presentation: Washington, DC, USA (Parallel session, 口頭発表)
  • Year and Date: 2013-11-04
• [Presentation] 急性肝不全の病態形成におけるGab1の意義:治療標的としての可能性について (2013)
  • Author(s): 古田訓丸、吉田雄一、竹原徹郎
  • Organizer: 第17回日本肝臓学会大会
  • Place of Presentation: 品川プリンスホテル, 東京(ワークショップ2、急性肝不全の予後改善に向けた病態理解と治療の進歩、口頭発表)
  • Year and Date: 2013-10-09
• [Presentation] 肝細胞のアダプター蛋白質Gab1は、胆汁うっ滞に伴う肝線維化に対して保護的に働く:炎症性ケモカインCCL5の関与 (2013)
  • Author(s): 木津崇、吉田雄一、古田訓丸、柄川真弓、茶谷徳啓、濱野美奈、江崎久男、鎌田佳宏、木曽真一、竹原徹郎
  • Organizer: 第49回日本肝臓学会総会
  • Place of Presentation: 京王プラザホテル, 東京(一般演題、肝線維化2、口頭発表)
  • Year and Date: 2013-06-06
• [Presentation] 肝細胞癌におけるFoxM1転写因子の発現意義:予後規定分子マーカーとしての可能性について (2013)
  • Author(s): 吉田雄一、柄川真弓、木曽真一、木津崇、古田訓丸、茶谷徳啓、濱野美奈、江崎久男、鎌田佳宏、友國晃、永野浩昭、土岐祐一郎、森正樹、竹原徹郎
  • Organizer: 第49回日本肝臓学会総会
  • Place of Presentation: 京王プラザホテル, 東京(一般演題、肝細胞癌・基礎3、口頭発表)
  • Year and Date: 2013-06-06
• [Presentation] 急性肝不全における肝細胞アダプター蛋白質Gab1の役割 (2013)
  • Author(s): 古田訓丸、吉田雄一、木津崇、柄川真弓、茶谷徳啓、濱野美奈、江崎久男、鎌田佳宏、木曽真一、竹原徹郎
  • Organizer: 第49回日本肝臓学会総会
  • Place of Presentation: 京王プラザホテル, 東京(一般演題、肝再生2、口頭発表)
  • Year and Date: 2013-06-06
• [Presentation] 肝内ERストレスの軽減が単純性脂肪肝の肝再生遅延に及ぼす効果 (2013)
  • Author(s): 濱野美奈、江崎久男、古田訓丸、木津崇、茶谷徳啓、鎌田佳宏、吉田雄一、木曽真一、竹原徹郎
  • Organizer: 第49回日本肝臓学会総会
  • Place of Presentation: 京王プラザホテル, 東京(一般演題、肝再生2、口頭発表)
  • Year and Date: 2013-06-06
• [Presentation] 急性肝不全の病態形成におけるGab1の意義：治療標的としての可能性について (2013)
  • Author(s): 古田訓丸、吉田雄一、竹原徹郎
  • Organizer: 第17回日本肝臓学会大会
  • Place of Presentation: 品川プリンスホテル（東京）
• [Presentation] 肝細胞癌におけるFoxM1転写因子の発現意義：予後規定分子マーカーとしての可能性について (2013)
  • Author(s): 吉田雄一 、柄川真弓 、木曽真一 、木津 崇 、古田訓丸 、茶谷徳啓 、濱野美奈 、江崎久男、鎌田佳宏、友國 晃 、永野浩昭 、土岐祐一郎 、森 正樹 、竹原徹郎
  • Organizer: 第49回日本肝臓学会総会
  • Place of Presentation: 京王プラザホテル（東京）
• [Presentation] Loss of Gab1 scaffolding adaptor protein in the hepatocytes exacerbates cholestasis-induced liver fibrosis in mice (2013)
  • Author(s): Takashi Kizu, Yuichi Yoshida, Kunimaro Furuta, Satoshi Ogura, Mayumi Egawa, Norihiro Chatani, Mina Hamano, Hisao Ezaki, Yoshihiro Kamada, Shinichi. Kiso, Tetsuo Takehara
  • Organizer: The 64th Annual Meeting of the American Association for the Study of Liver Diseases
  • Place of Presentation: Walter E. Washington Convention Center, Washington DC, USA
• [Presentation] Lack of secreted frizzled-related protein 5 (Sfrp5), an adipocytokine, enhanced carbon-tetrachloride-induced liver fibrosis in mice (2013)
  • Author(s): Norihiro Chatani, Yoshihiro Kamada, Takashi Kizu, Satoshi Ogura, Kunimaro Furuta, Mayumi Egawa, Mina Hamano, Hisao Ezaki, Shinichi. Kiso, Akihiko Shimano, Noriyuki Ouchi, Yuichi Yoshida, Tetsuo Takehara
  • Organizer: The 64th Annual Meeting of the American Association for the Study of Liver Diseases
  • Place of Presentation: Walter E. Washington Convention Center, Washington DC, USA
• [Presentation] Serum Mac-2 binding protein levels as a novel diagnostic biomarker for prediction of disease severity and nonalcoholic steatohepatitis (2013)
  • Author(s): Yoshihiro Kamada, Hideki Fujii, Hironobu Fujii, Yoshinori Doi, Kayo Mizutani, Maaya Akita, Motoya Sato, Sachiho Kida, Noriaki Kinoshita, Nobuhiro Maruyama, Takayuki Yakushijin, Masanori Miyazaki, Hisao Ezaki, Naoki Hiramatsu, Yuichi Yoshida, Shinichi Kiso, Norifumi Kawada, Tetsuo Takehara and Eiji Miyoshi
  • Organizer: The 64th Annual Meeting of the American Association for the Study of Liver Diseases
  • Place of Presentation: Walter E. Washington Convention Center, Washington DC, USA
• [Presentation] 急性肝不全における肝細胞アダプター蛋白質Gab1の役割 (2013)
  • Author(s): 古田訓丸、吉田雄一、木津崇、柄川真弓、茶谷徳啓、濱野美奈、江崎久男、鎌田佳宏、木曽真一、竹原徹郎
  • Organizer: 第49回日本肝臓学会総会
  • Place of Presentation: 京王プラザホテル（東京）
• [Presentation] 肝細胞のアダプター蛋白質Gab1は、胆汁うっ滞に伴う肝線維化に対して保護的に働く：炎症性ケモカインCCL５の関与 (2013)
  • Author(s): 木津 崇、吉田雄一、古田訓丸、柄川真弓、茶谷徳啓、濱野美奈、江崎久男、鎌田佳宏、木曽真一、竹原徹郎
  • Organizer: 第49回日本肝臓学会総会
  • Place of Presentation: 京王プラザホテル（東京）
• [Presentation] Crucial role of FoxM1 transcription factor as a predictor of clinical outcomes in patients with hepatocellular carcinoma (2012)
  • Author(s): Mayumi Egawa, Yuichi Yoshida, Shinichi Kiso, Akira Tomokuni, Takashi Kizu, Kunimaro Furuta, Takayo Takemura, Mina Hamano, Norihiro Chatani, Hisao Ezaki, Yoshihiro Kamada, Hiroaki Nagano, Yuichiro Doki, Masaki Mori, and Tetsuo Takehara
  • Organizer: The 63rd Annual Meeting of the American Association for the Study of Liver Diseases
  • Place of Presentation: Hynes Convention Center, Boston, Massachusetts, USA (Parallel session, 口頭発表)
  • Year and Date: 2012-11-12
• [Presentation] Association of lipid overaccumulation with delayed liver regeneration in mice with simple steatosis (2012)
  • Author(s): Mina Hamano, Hisao Ezaki, Kunimaro Furuta, Mayumi Egawa, Takashi Kizu, Norihiro Chatani, Yoshihiro Kamada, Yuichi Yoshida, Shinichi Kiso, Tetsuo Takehara
  • Organizer: The 63rd Annual Meeting of the American Association for the Study of Liver Diseases
  • Place of Presentation: Hynes Convention Center, Boston, Massachusetts, USA(ポスター発表)
  • Year and Date: 2012-11-12
• [Presentation] HB-EGF(heparin-binding EGF-like growth factor)による肝線維化制御:TGF-βシグナルとのクロストークについて (2012)
  • Author(s): 竹村貴代、吉田雄一、古田訓丸、木津崇、柄川真弓、茶谷徳啓、濱野美奈、江崎久男、鎌田佳宏、木曽真一、竹原徹郎
  • Organizer: 第54回日本消化器病学会大会(第20回日本消化器関連学会週間)
  • Place of Presentation: 神戸国際会議場, 神戸(ポスター発表)
  • Year and Date: 2012-10-10
• [Presentation] 肝細胞におけるアダプター蛋白質Gab1欠損は、マウス肝線維化を増悪させる (2012)
  • Author(s): 木津崇、吉田雄一、古田訓丸、竹村貴代、柄川真弓、茶谷徳啓、濱野美奈、江崎久男、鎌田佳宏、木曽真一、竹原徹郎
  • Organizer: 第54回日本消化器病学会大会(第20回日本消化器関連学会週間)
  • Place of Presentation: 神戸国際会議場, 神戸(ポスター発表)
  • Year and Date: 2012-10-10
• [Presentation] (2012)
  • Author(s): 柄川真弓、吉田雄一、木曽真一、木津崇、古田訓丸、竹村貴代、茶谷徳啓、濱野美奈、江崎久男、鎌田佳宏、友國晃、永野浩昭、土岐祐一郎、森正樹、竹原徹郎
  • Organizer: 第54回日本消化器病学会大会(第20回日本消化器関連学会週間)
  • Place of Presentation: 神戸国際会議場, 神戸(ポスター発表)
  • Year and Date: 2012-10-10
• [Presentation] マウス肝線維化過程におけるアダプター蛋白質Gab1の関与 (2012)
  • Author(s): 木津崇、吉田雄一、古田訓丸、竹村貴代、柄川真弓、茶谷徳啓、濱野美奈、江崎久男、鎌田佳宏、木曽真一、竹原徹郎
  • Organizer: 第48回日本肝臓学会総会
  • Place of Presentation: ホテル日航金沢(オープンワークショップ38肝線維化1、口頭発表)
  • Year and Date: 2012-06-08
• [Presentation] HB-EGF(heparin binding EGF-like growth factor)欠損は、マウス胆汁うっ滞モデルにおける肝線維化を増悪させる (2012)
  • Author(s): 竹村貴代、吉田雄一、木津崇、椿尾真弓、茶谷徳啓、濱野美奈、江崎久男、鎌田佳宏、木曽真一、林紀夫
  • Organizer: 第48回日本肝臓学会総会
  • Place of Presentation: ホテル日航金沢(オープンワークショップ38肝線維化1、口頭発表)
  • Year and Date: 2012-06-08
• [Presentation] ヒト肝細胞癌の予後決定因子としてのFoxM1転写因子の意義:新規分子標的治療のターゲットとしての可能性について (2012)
  • Author(s): 柄川真弓、吉田雄一、木曽真一、木津崇、古田訓丸、竹村貴代、茶谷徳啓、濱野美奈、江崎久男、鎌田佳宏、友國晃、永野浩昭、土岐祐一郎、森正樹、竹原徹郎
  • Organizer: 第48回日本肝臓学会総会
  • Place of Presentation: ホテル日航金沢(オープンワークショップ9肝癌基礎3、口頭発表)
  • Year and Date: 2012-06-07
• [Presentation] マウスの高脂肪食誘発単純性脂肪肝モデルにおける70%部分肝切除後の肝再生障害についての検討 (2012)
  • Author(s): 濱野美奈、江崎久男、古田訓丸、柄川真弓、木津崇、茶谷徳啓、竹村貴代、鎌田佳宏、吉田雄一、木曽真一、竹原徹郎
  • Organizer: 第48回日本肝臓学会総会
  • Place of Presentation: ホテル日航金沢(オープンワークショップ12肝分化・再生・幹細胞1、口頭発表)
  • Year and Date: 2012-06-07
• [Presentation] 肝再生療法の新規標的分子としてのアダプター蛋白質Gab1の意義とその肝幹細胞制御について (2012)
  • Author(s): 吉田雄一、木曽真一、竹原徹郎
  • Organizer: 第48回日本肝臓学会総会
  • Place of Presentation: ANAクラウンプラザホテル金沢(ワークショップ15肝再生、幹細胞研究が臨床医学にもたらす可能性口頭発表)
  • Year and Date: 2012-06-07
• [Presentation] Concanavalin A誘導性肝炎におけるN-アセチルグルコサミン転移酵素V(GnT-V)の役割 (2012)
  • Author(s): 佐藤元哉、鎌田佳宏、木田祥穂、藤井宏修、石井真悠子、吉田雄一、木曽真一、竹原徹郎、三善英知
  • Organizer: 第48回日本肝臓学会総会
  • Place of Presentation: ANAクラウンプラザホテル金沢(オープンワークショップ22肝疾患基礎、口頭発表)
  • Year and Date: 2012-06-07
• [Presentation] 肝再生療法の新規標的分子としてのアダプター蛋白質Gab1の意義とその肝幹細胞制御について (2012)
  • Author(s): 吉田雄一 木曽真一 竹原徹郎
  • Organizer: 第48回日本肝臓学会総会
  • Place of Presentation: ANAクラウンプラザホテル金沢（金沢）
• [Presentation] HB-EGF(heparin binding EGF-like growth factor)欠損は、マウス胆汁うっ滞モデルにおける肝線維化を増悪させる (2012)
  • Author(s): 竹村貴代、吉田雄一、木津 崇、椿尾真弓、茶谷徳啓、濱野美奈、江崎久男、鎌田佳宏、木曽真一、林 紀夫
  • Organizer: 第48回日本肝臓学会総会
  • Place of Presentation: ホテル日航金沢（金沢）
• [Presentation] マウス肝線維化過程におけるアダプター蛋白質Gab1の関与 (2012)
  • Author(s): 木津 崇、 吉田雄一、古田訓丸、竹村貴代 、柄川真弓、茶谷徳啓、濱野美奈、江崎久男 鎌田佳宏、木曽真一、竹原徹郎
  • Organizer: 第48回日本肝臓学会総会
  • Place of Presentation: ホテル日航金沢（金沢）
• [Presentation] ヒト肝細胞癌の予後決定因子としてのFoxM1転写因子の意義：新規分子標的治療のターゲットとしての可能性について (2012)
  • Author(s): 柄川真弓、吉田雄一、木曽真一、木津 崇、古田訓丸、竹村貴代、茶谷徳啓、濱野美奈、江崎久男、鎌田佳宏、友國 晃、永野浩昭、土岐祐一郎、森 正樹、竹原徹郎
  • Organizer: 第48回日本肝臓学会総会
  • Place of Presentation: ホテル日航金沢（金沢）
• [Presentation] マウスの高脂肪食誘発単純性脂肪肝モデルにおける70％部分肝切除後の肝再生障害についての検討 (2012)
  • Author(s): 濱野美奈、江崎久男、古田訓丸、柄川真弓、木津 崇、茶谷徳啓、竹村貴代、鎌田佳宏、吉田雄一、木曽真一、竹原徹郎
  • Organizer: 第48回日本肝臓学会総会
  • Place of Presentation: ホテル日航金沢（金沢）
• [Presentation] Concanavalin A 誘導性肝炎におけるN-アセチルグルコサミン転移酵素V（GnT-V）の役割 (2012)
  • Author(s): 佐藤元哉、鎌田佳宏、木田祥穂、藤井宏修、石井真悠子、吉田雄一、木曽真一、竹原徹郎、三善英知
  • Organizer: 第48回日本肝臓学会総会
  • Place of Presentation: ANAクラウンプラザホテル金沢（金沢）
• [Presentation] HB-EGF(heparin-binding EGF-like growth factor)による肝線維化制御：TGF-βシグナルとのクロストークについて (2012)
  • Author(s): 竹村貴代、吉田雄一、古田訓丸、木津 崇、柄川真弓、茶谷徳啓、濱野美奈、江崎久男、鎌田佳宏、木曽真一、竹原徹郎
  • Organizer: 第54回日本消化器病学会大会
  • Place of Presentation: 神戸国際展示場（神戸）
• [Presentation] 肝細胞におけるアダプター蛋白質Gab1欠損は、マウス肝線維化を増悪させる (2012)
  • Author(s): 木津 崇、吉田雄一、古田訓丸、竹村貴代、柄川真弓、茶谷徳啓、濱野美奈、江崎久男、鎌田佳宏、木曽真一、竹原徹郎
  • Organizer: 第54回日本消化器病学会大会
  • Place of Presentation: 神戸国際展示場（神戸）
• [Presentation] ヒト肝細胞癌におけるFoxM1転写因子の発現意義について (2012)
  • Author(s): 柄川真弓、吉田雄一、木曽真一、木津 崇、古田訓丸、竹村貴代、茶谷徳啓、濱野美奈、江崎久男、鎌田佳宏、友國 晃、永野浩昭、土岐祐一郎、森 正樹、竹原徹郎
  • Organizer: 第54回日本消化器病学会大会
  • Place of Presentation: 神戸国際展示場（神戸）
• [Presentation] Crucial role of FoxM1 transcription factor as a predictor of clinical outcomes in patients with hepatocellular carcinoma. (2012)
  • Author(s): Mayumi Egawa, Yuichi Yoshida, Shinichi Kiso, et al.
  • Organizer: The 63rd Annual Meeting of the American Association for the Study of Liver Diseases
  • Place of Presentation: Hynes Convention Center, Boston, Massachusetts, USA
• [Presentation] Association of lipid overaccumulation with delayed liver regeneration in mice with simple steatosis (2012)
  • Author(s): Mina Hamano, Hisao Ezaki, Kunimaro Furuta, Mayumi Egawa, Takashi Kizu, Norihiro Chatani, Yoshihiro Kamada, Yuichi Yoshida, Shinichi Kiso, Tetsuo Takehara
  • Organizer: The 63rd Annual Meeting of the American Association for the Study of Liver Diseases
  • Place of Presentation: Hynes Convention Center, Boston, Massachusetts, USA
• [Presentation] Pitavastatin administration ameliorated the progression of steatohepatitis in ovariectomized mice fed with high fat and high cholesterol diet (2011)
  • Author(s): Kamada Y, Kiso S, Yoshida Y, Chatani N, Kizu T,Hamano M, Tsubakio M, Takemura T, Ezaki H, Hayashi N, Tetsuo Takehara
  • Organizer: The 62nd Annual Meeting of the American Association for the Study of Liver Diseases
  • Place of Presentation: Moscone West Convention Center, San Francisco, USA(ポスター発表)
  • Year and Date: 2011-11-07
• [Presentation] Gab1 scaffolding adaptor protein protects from liver fibrosis during chronic liver injury in mice (2011)
  • Author(s): Kizu T, Yoshida Y, Takemura T, Furuta K,Kamada Y, Chatani N, Hamano M, Tsubakio M, Ezaki H, Kiso S, Takehara T
  • Organizer: The 62nd Annual Meeting of the American Association for the Study of Liver Diseases
  • Place of Presentation: Moscone West Convention Center, San Francisco, USA(ポスター発表)
  • Year and Date: 2011-11-06
• [Presentation] 肝細胞癌におけるGab1の関与と肝細胞癌治療の新規分子標的としての可能性 (2011)
  • Author(s): 吉田雄一、木曽真一、椿尾真弓、木津崇、茶谷徳啓、古田訓丸、濱野美奈、竹村貴代、江崎久男、鎌田佳宏、竹原徹郎
  • Organizer: 第15回日本肝臓学会大会
  • Place of Presentation: 福岡国際センター, 福岡(ポスター発表)
  • Year and Date: 2011-10-20
• [Presentation] 肝再生・肝線維化進展過程におけるGab1の意義と肝幹/前駆細胞の関与 (2011)
  • Author(s): 吉田雄一、木曽真一、木津崇、竹原徹郎
  • Organizer: 第15回日本肝臓学会大会
  • Place of Presentation: 福岡国際センター, 福岡(ポスター発表)
  • Year and Date: 2011-10-20
• [Presentation] 肝細胞癌におけるGab1の関与と肝細胞癌治療の新規分子標的としての可能性
  • Author(s): 吉田雄一、木曽真一、椿尾真弓、木津 崇、茶谷徳啓、古田訓丸、濱野美奈、竹村貴代、江崎久男、鎌田佳宏、竹原徹郎
  • Organizer: 第15回日本肝臓学会大会
  • Place of Presentation: 福岡国際センター（福岡）
• [Presentation] 肝再生・肝線維化進展過程におけるGab1の意義と肝幹/前駆細胞の関与
  • Author(s): 吉田雄一、木曽真一、木津 崇、竹原徹郎
  • Organizer: 第15回日本肝臓学会大会
  • Place of Presentation: 福岡国際センター（福岡）
• [Presentation] Protective role of heparin-binding EGF-like growth factor during liver fibrosis in mice
  • Author(s): Takemura T, Yoshida Y, Kizu T, Furuta K, Kamada Y, Hamano M, Tsubakio M, Chatani N, Ezakki H, Kiso S, Takehara T
  • Organizer: 62nd Annual Meeting of the America Association for the Study of Liver Diseases
  • Place of Presentation: Moscone West Convention Center, San Francisco, USA
• [Presentation] Gab1 scaffolding adaptor protein protects from liver fibrosis during chronic liver injury in mice
  • Author(s): Kizu T, Yoshida Y, Takemura T, Furuta K, Kamada Y, Chatani N, Hamano M, Tsubakio M, Ezaki H, Kiso S, Takehara T
  • Organizer: 62nd Annual Meeting of the America Association for the Study of Liver Diseases
  • Place of Presentation: Moscone West Convention Center, San Francisco, USA
• [Presentation] Pitavastatin administration ameliorated the progression of steatohepatitis in ovariectomized mice fed with high fat and high cholesterol diet
  • Author(s): Kamada Y, Kiso S, Yoshida Y, Chatani N, Kizu T Hamano M, Tsubakio M, Takemura T, Ezaki H, Hayashi N, Tetsuo Takehara
  • Organizer: 62nd Annual Meeting of the America Association for the Study of Liver Diseases
  • Place of Presentation: Moscone West Convention Center, San Francisco, USA
• [Remarks] ホームページ
  • URL: http://www.med.osaka-u.ac.jp/pub/gh/