Prediction of the effect of chemotherapy for hepatocellular carcinoma with new parameters

• Project/Area Number: 23590976
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Okayama University
• Principal Investigator: NOUSO Kazuhiro 岡山大学, 医歯(薬)学総合研究科, 准教授 (10314668)
• Co-Investigator(Kenkyū-buntansha): SHIRAHA Hidenori 岡山大学, 大学病院, 講師 (40379748) ; NAKAMURA Shinichiro 岡山大学, 大学病院, 助教 (70514230)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 肝細胞癌 / 化学療法

Research Abstract

To improve survival of the patients with advanced hepatocellular carcinoma, we tried to establish markers that could predict the efficacy of chemotherapies. By measuring serum 8 cytokines simultaneously, close correlation was observed between high cytokine expressions and poor prognosis. In addition, comprehensive glycan analysis revealed that survival of the patients with high serum tri-antennary glycan (G2890) expression was shorter than that with the low expression.

Research Products

• [Journal Article] Serum glycan as a prognostic marker in patients with advanced hepatocellular carcinoma treated with sorafenib (2014)
  • Author(s): Miyahara K, Nouso K, Nakamura S, et al. (他6名)
  • Journal Title: Hepatology Volume: 59 Pages: 355-355
  • URL: http://www.ncbi.nlm.nih.gov/pubmed/23729393
  • Peer Reviewed
• [Journal Article] Efficacy of sorafenib beyond first progression in patients with metastatic hepatocellular carcinoma (2014)
  • Author(s): Miyahara K, Nouso K, Nakamura S, Shiraha H, et al. (他15名)
  • Journal Title: Hepatol Res Volume: 44 Pages: 294-301
  • URL: http://www.ncbi.nlm.nih.gov/pubmed/23607549
  • Peer Reviewed
• [Journal Article] Anti-programmed cell death-1 antibody as a new serological marker for type 1 autoimmune hepatitis (2014)
  • Author(s): Matsumoto K, Shiraha H, Nouso K, et al. (他6名)
  • Journal Title: J Gastroenterol Hepatol Volume: 29 Pages: 110-5
  • URL: http://www.ncbi.nlm.nih.gov/pubmed/23869988
  • Peer Reviewed
• [Journal Article] Serum glycan as a prognostic marker in patients with advanced hepatocellular carcinoma treated with sorafenib (2014)
  • Author(s): Miyahara K, Nouso K, Miyake Y, Nakamura S, Obi S, Amano M, Hirose K, Nishimura S, Yamamoto K
  • Journal Title: Hepatology Volume: 59 Issue: 1 Pages: 355
  • DOI: 10.1002/hep.26531
  • Peer Reviewed
• [Journal Article] Effect of hepatic arterial infusion chemotherapy of 5-fluorouracil and cisplatin for advanced hepatocellular carcinoma in the Nationwide Survey of Primary Liver Cancer in Japan (2013)
  • Author(s): Nouso K, Miyahara K, et al.(他16名)
  • Journal Title: Br J Cancer Volume: 109 Pages: 1904-7
  • URL: http://www.ncbi.nlm.nih.gov/pubmed/18349849
  • Peer Reviewed
• [Journal Article] Pro-angiogenic cytokines for prediction of outcomes in patients with advanced hepatocellular carcinoma (2013)
  • Author(s): Miyahara K, Nouso K, Nakamura S, Shiraha H, et al. (他20名)
  • Journal Title: Br J Cancer Volume: 109 Pages: 2072-8
  • URL: http://www.ncbi.nlm.nih.gov/pubmed/24045661
  • Peer Reviewed
• [Journal Article] Measurement of spleen stiffness by acoustic radiation force impulse imaging identifies cirrhotic patients with esophageal varices (2013)
  • Author(s): Takuma Y, Nouso K, et al. (他10名)
  • Journal Title: Gastroenterology Volume: 144
  • URL: http://www.ncbi.nlm.nih.gov/pubmed/23022955
  • Peer Reviewed
• [Journal Article] Prognotic impact of serum follistatin in patients with hepatocellular carcinoma (2013)
  • Author(s): Tomoda T, Nouso K, Miyahara K, Nakamura S, Shiraha H, et al. (他10名)
  • Journal Title: J Gastroenterol Hepatol Volume: 28 Pages: 1391-6
  • URL: http://www.ncbi.nlm.nih.gov/pubmed/23432377
  • Peer Reviewed
• [Journal Article] Clinical utility of high-throughput glycome analysis in patients with pancreatic cancer (2013)
  • Author(s): Nouso K, Miyahara K, Nakamura S, Shiraha H, et al. (他17名)
  • Journal Title: J Gastroenterol Volume: 48 Pages: 1171-9
  • URL: http://www.ncbi.nlm.nih.gov/pubmed/23307043
  • Peer Reviewed
• [Journal Article] Current chemotherapies for advanced hepatocellular carcinoma (2013)
  • Author(s): Nouso K
  • Journal Title: Clin J Gastroenterol Volume: 6 Pages: 89-93
  • Peer Reviewed
• [Journal Article] Evaluation of the effect of sorafenib using serum NX-des-gamma-carboxyprothrombin in patients with hepatocellular carcinoma (2013)
  • Author(s): Miyahara K, Nouso K, Nakamura S, Shiraha H, et al. (他11名)
  • Journal Title: Hepatol Res Volume: 43 Pages: 1064-70
  • URL: http://www.ncbi.nlm.nih.gov/pubmed/23347420
  • Peer Reviewed
• [Journal Article] The Diagnosis of Hypovascular Hepatic Lesions Showing Hypo-intensity in the Hepatobiliary Phase of Gd-EOB- DTPA-enhanced MR Imaging in High-risk Patients for Hepatocellular Carcinoma (2013)
  • Author(s): Nakamura S, Nouso K, Shiraha H, et al. (他7名)
  • Journal Title: Acta Med Okayama Volume: 67 Pages: 239-44
  • NAID: 120005315585
  • URL: http://www.ncbi.nlm.nih.gov/pubmed/23970322
  • Peer Reviewed
• [Journal Article] Pro-angiogenic cytokines for prediction of outcomes in patients with advanced hepatocellular carcinoma (2013)
  • Author(s): Miyahara K, Nouso K, Morimoto Y, Takeuchi Y, Hagihara H, Kuwaki K, Onishi H, Ikeda F, Miyake Y, Nakamura S, Shiraha H, Takaki A, Honda M, Kaneko S, Sato T, Sato S, Obi S, Iwadou S, Kobayashi Y, Takaguchi K, Kariyama K, Takuma Y, Takabatake H, Yamamoto K
  • Journal Title: Br J Cancer Volume: 109 Issue: 7 Pages: 2072-2078
  • DOI: 10.1038/bjc.2013.542
  • Peer Reviewed
• [Journal Article] Evaluation of the effect of sorafenib using serum NX-des-γ-carboxyprothrombin in patients with hepatocellular carcinoma. (2013)
  • Author(s): Miyahara K, Nouso K, Morimoto Y, Tomoda T, Kobayashi S, Takeuchi Y, Hagihara H, Kuwaki K, Ohnishi H, Ikeda F, Miyake Y, Nakamura S, Shiraha H, Takaki A, Yamamoto K
  • Journal Title: Hepatol Res. Volume: 43(10) Issue: 10 Pages: 1064-70
  • DOI: 10.1111/hepr.12055
  • Peer Reviewed
• [Journal Article] Prognotic impact of serum follistatin in patients with hepatocellular carcinoma. (2013)
  • Author(s): Tomoda T, Nouso K, Miyahara K, Kobayashi S, Kinugasa H, Toyosawa J, Hagihara H, Kuwaki K, Onishi H, Nakamura S, Ikeda F, Miyake Y, Shiraha H, Takaki A, Yamamoto K.
  • Journal Title: J Gastroenterol Hepatol. Volume: 28(8) Issue: 8 Pages: 1391-6
  • DOI: 10.1111/jgh.12167
  • Peer Reviewed
• [Journal Article] The impact of patatin-like phospholipase domain-containing protein 3 polymorphism on hepatocellular carcinoma prognosis (2013)
  • Author(s): Yasuto Takeuchi, Fusao Ikeda, Yuki Moritou, Hiroaki Hagihara, Tetsuya Yasunaka, Kenji Kuwaki, Yasuhiro Miyake, Hideki Ohnishi, Shinichiro Nakamura, Hidenori Shiraha, Akinobu Takaki, Yoshiaki Iwasaki, Kazuhiro Nouso, Kazuhide Yamamoto
  • Journal Title: Journal of Gastroenterology Volume: 48巻 Issue: 3 Pages: 405-412
  • DOI: 10.1007/s00535-012-0647-3
  • NAID: 10031169215
  • Peer Reviewed
• [Journal Article] Measurement of Spleen Stiffness by Acoustic Radiation Force Impulse Imaging Identifies Cirrhotic Patients with Esophageal Varices. (2013)
  • Author(s): Takuma Y, Nouso K, Morimoto Y, Tomokuni J, Sahara A, Toshikuni N, Takabatake H, Shimomura H, Doi A, Sakakibara I, Matsueda K, Yamamoto H.
  • Journal Title: Gastroenterology Volume: 144(1) Issue: 1 Pages: 92-101
  • DOI: 10.1053/j.gastro.2012.09.049
  • Peer Reviewed
• [Journal Article] Clinical utility of high-throughput glycome analysis in patients with pancreatic cancer. (2013)
  • Author(s): Nouso K, Amano M, Ito YM, Miyahara K, Morimoto Y, Kato H, et al.
  • Journal Title: J Gastroenterol. Volume: Jan11
  • Peer Reviewed
• [Journal Article] Which patients respond best to hepatitis B vaccination after a hepatitis B virus-related liver transplantation? (2013)
  • Author(s): Takaki A, Yagi T, Yasunaka T, Sadamori H, Shinoura S, Umeda Y, Yoshida R, Sato D, Nobuoka D, Utsumi M, Yasuda Y, Nakayama E, Miyake Y, Ikeda F, Shiraha H, Nouso K, Fujiwara T, Yamamoto K.
  • Journal Title: J Gastroenterol. 2013 Volume: Feb23
  • Peer Reviewed
• [Journal Article] Risk factors for recurrence after transarterial chemoembolization for early-stage hepatocellular carcinoma (2012)
  • Author(s): Kinugasa H, Nouso K, Nakamura S, Shiraha H, et al. (他9名)
  • Journal Title: J Gastroenterol Volume: 47 Pages: 421-6
  • NAID: 10030650091
  • URL: http://www.ncbi.nlm.nih.gov/pubmed/22048256
  • Peer Reviewed
• [Journal Article] Clinical utility of serum fucosylated hemopexin in Japanese patients with hepatocellular carcinoma (2012)
  • Author(s): Kobayashi S, Nouso K, Miyahara K, Kinugasa H, Nakamura S, Shiraha H, et al. (他9名)
  • Journal Title: Hepatol Res Volume: 42 Pages: 1187-95
  • NAID: 120005311965
  • URL: http://www.ncbi.nlm.nih.gov/pubmed/22639859
  • Peer Reviewed
• [Journal Article] Effect of previous interferon treatment on outcome after curative treatment for hepatitis C virus-related hepatocellular carcinoma (2012)
  • Author(s): Miyatake H, Kobayashi Y, Nakamura S, Nouso K, et al. (他6名)
  • Journal Title: Dig Dis Sci Volume: 57 Pages: 1092-101
  • URL: http://www.ncbi.nlm.nih.gov/pubmed/21989822
  • Peer Reviewed
• [Journal Article] Genetic risk of hepatocellular carcinoma in patients with hepatitis C virus : a case control study (2012)
  • Author(s): Tomoda T, Nouso K, Miyahara K, Nakamura S, et al. (他6名)
  • Journal Title: J Gastroenterol Hepatol Volume: 27 Pages: 797-804
  • URL: http://www.ncbi.nlm.nih.gov/pubmed/22004425
  • Peer Reviewed
• [Journal Article] Runt-related transcription factor 3 reverses epithelial-mesenchymal transition in hepatocellular carcinoma (2012)
  • Author(s): Tanaka S, Shiraha H, Nakamura S, Nouso K, et al. (他14名)
  • Journal Title: Int J Cancer Volume: 131 Pages: 2537-46
  • NAID: 120005232496
  • URL: http://www.ncbi.nlm.nih.gov/pubmed/22488108
  • Peer Reviewed
• [Journal Article] Cost-effectiveness analysis on the surveillance for hepatocellular carcinoma in liver cirrhosis patients using contrast-enhanced ultrasonography (2012)
  • Author(s): Tanaka H, Iijima H, Nouso K, et al.(他12名)
  • Journal Title: Hepatol Res Volume: 42 Pages: 376-84
  • NAID: 10031144250
  • URL: http://www.ncbi.nlm.nih.gov/pubmed/22221694
  • Peer Reviewed
• [Journal Article] Des-gamma-carboxyl prothrombin is associated with tumor angiogenesis in hepatocellular carcinoma (2012)
  • Author(s): Matsubara M, Shiraha H, Nakamura S, Nouso K, et al. (他9名)
  • Journal Title: J Gastroenterol Hepatol Volume: 27 Pages: 1602-8
  • NAID: 120005359099
  • URL: http://www.ncbi.nlm.nih.gov/pubmed/22554292
  • Peer Reviewed
• [Journal Article] Genetic risk of hepatocellular carcinoma in patients with hepatitis C virus: a case control study. (2012)
  • Author(s): Tomoda T, Nouso K, Sakai A, Ouchida M, Kobayashi S, Miyahara K, Onishi H, Nakamura S, Yamamoto K, Shimizu K.
  • Journal Title: J Gastroenterol Hepatol. Volume: 27(4) Issue: 4 Pages: 797-804
  • DOI: 10.1111/j.1440-1746.2011.06948.x
  • Peer Reviewed
• [Journal Article] Risk factors for recurrence after transarterial chemoembolization for early-stage hepatocellular carcinoma. (2012)
  • Author(s): Kinugasa H, Nouso K, Takeuchi Y, Yasunaka T, Onishi H, Nakamura S, Shiraha H, Kuwaki K, Hagihara H, Ikeda F, Miyake Y, Takaki A, Yamamoto K.
  • Journal Title: J Gastroenterol. Volume: 47(4) Issue: 4 Pages: 421-6
  • DOI: 10.1007/s00535-011-0492-9
  • NAID: 10030650091
  • Peer Reviewed
• [Journal Article] Cost-effectiveness analysis on the surveillance for hepatocellular carcinoma in liver cirrhosis patients using contrast-enhanced ultrasonography. (2012)
  • Author(s): Tanaka H, Iijima H, Nouso K, Aoki N, Iwai T, Takashima T, Sakai Y, Aizawa N, Iwata K, Ikeda N, Iwata Y, Enomoto H, Saito M, Imanishi H, Nishiguchi S
  • Journal Title: Hepatol Res. Volume: 42(4) Issue: 4 Pages: 376-384
  • DOI: 10.1111/j.1872-034x.2011.00936.x
  • NAID: 10031144250
  • Peer Reviewed
• [Journal Article] Runt-related transcription factor 3 reverses epithelial-mesenchymal transition in hepatocellular carcinoma (2012)
  • Author(s): Tanaka S, Shiraha H, Nakanishi Y, Nishina S, Matsubara M, Horiguchi S, Takaoka N, Iwamuro M, Kataoka J, Kuwaki K, Hagihara H, Toshimori J, Ohnishi H, Takaki A, Nakamura S, Nouso K, Yagi T, Yamamoto K
  • Journal Title: Int J Cancer Volume: 131(11) Issue: 11 Pages: 2537-46
  • DOI: 10.1002/ijc.27575
  • NAID: 120005232496
  • Peer Reviewed
• [Journal Article] Des-γ-carboxyl prothrombin is associated with tumor angiogenesis in hepatocellular carcinoma. (2012)
  • Author(s): Matsubara M, Shiraha H, Kataoka J, Iwamuro M, Horiguchi S, Nishina S, Takaoka N, Uemura M, Takaki A, Nakamura S, Kobayashi Y, Nouso K, Yamamoto K.
  • Journal Title: J Gastroenterol Hepatol. Volume: 27(10) Issue: 10 Pages: 1602-8
  • DOI: 10.1111/j.1440-1746.2012.07173.x
  • Peer Reviewed
• [Journal Article] Clinical utility of serum fucosylated hemopexin in Japanese patients with hepatocellular carcinoma. (2012)
  • Author(s): Kobayashi S, Nouso K, Kinugasa H, Takeuchi Y, Tomoda T, Miyahara K, Hagihara H, Kuwaki K, Onishi H, Nakamura S, Ikeda F, Miyake Y, Shiraha H, Takaki A, Yamamoto K.
  • Journal Title: Hepatol Res. Volume: 42(12) Issue: 12 Pages: 1187-95
  • DOI: 10.1111/j.1872-034x.2012.01044.x
  • NAID: 120005311965
  • Peer Reviewed
• [Journal Article] Serum oxidative-anti-oxidative stress balance is dysregulated in patients with hepatitis C virus-related hepatocellular carcinoma. (2012)
  • Author(s): Nishimura M, Takaki A, Tamaki N, Maruyama T, Onishi H, Kobayashi S, Nouso K, Yasunaka T, Koike K, Hagihara H, Kuwaki K, Nakamura S, Ikeda F, Iwasaki Y, Tomofuji T, Morita M, Yamamoto K.
  • Journal Title: Hepatol Res. Volume: Dec20 Issue: 10 Pages: 1078-1092
  • DOI: 10.1111/hepr.12048
  • NAID: 120005324799
  • Peer Reviewed
• [Journal Article] 門脈腫瘍栓合併肝細胞癌への放射線療法の治療効果 (2012)
  • Author(s): 大西秀樹、能粗一裕、小林功幸、白羽英則、中村進一郎、三宅康広、歳森淳一、桑木健志、萩原宏明、山本和秀
  • Journal Title: 消化器内科 Volume: 54（1） Pages: 110-114
• [Journal Article] 超音波ガイド下肝穿刺における新プローブの臨床評価 マイクロコンベックスプローブの有用性について (2012)
  • Author(s): 中村進一郎、大西秀樹、白羽英則、桑木健志、萩原宏明、竹内康人、能祖一裕、山本和秀
  • Journal Title: INNERVISION Volume: 25（5） Pages: 82-85
• [Journal Article] 【肝疾患up to date-プライマリ・ケアで押さえておきたい最新トピックス-】 その他の病態に関するトピックス B型肝炎でもない、C型肝炎でもない慢性肝疾患の診かた (2012)
  • Author(s): 能祖一裕
  • Journal Title: 治療.2012;94(9):1602-1607 Volume: 94（9） Pages: 1602-1607
• [Journal Article] Percutaneous radiofrequency ablation for treatment of hepatocellular carcinoma in the caudate lobe (2011)
  • Author(s): Kariyama K, Nouso K, Wakuta A, et al.(他4名)
  • Journal Title: AJR Am J Roentgenol Volume: 197
  • URL: http://www.ncbi.nlm.nih.gov/pubmed/21940528
  • Peer Reviewed
• [Journal Article] Effect of pegylated interferon therapy on intrahepatic recurrence after curative treatment of hepatitis C virus-related hepatocellular carcinoma (2011)
  • Author(s): Hagihara H, Nouso K, Nakamura S, Shiraha H, et al. (他7名)
  • Journal Title: Int J Clin Oncol Volume: 16 Pages: 210-20
  • NAID: 10029526889
  • URL: http://www.ncbi.nlm.nih.gov/pubmed/21152943
  • Peer Reviewed
• [Journal Article] Prognostic importance of fucosylated alpha-fetoprotein in hepatocellular carcinoma patients with low alpha-fetoprotein (2011)
  • Author(s): Nouso K, Kobayashi Y, Nakamura S, Shiraha H, et al. (他12名)
  • Journal Title: J Gastroenterol Hepatol Volume: 26 Pages: 1195-200
  • URL: http://www.ncbi.nlm.nih.gov/pubmed/21410750
  • Peer Reviewed
• [Journal Article] Radiofrequency ablation for the treatment of hepatocellular carcinoma with decompensated cirrhosis (2011)
  • Author(s): Wakuta A, Nouso K, Kariyama K, et al.(他6名)
  • Journal Title: Oncology Volume: 81 Pages: 39-44
  • URL: http://www.ncbi.nlm.nih.gov/pubmed/21912196
  • Peer Reviewed
• [Journal Article] Hepatocellular carcinoma occurring in hepatobiliary fibropolycystic disease (2011)
  • Author(s): Kinugasa H, Nouso K, Nakamura S, Shiraha H, et al. (他12名)
  • Journal Title: Hepatol Res Volume: 41 Pages: 277-81
  • URL: http://www.ncbi.nlm.nih.gov/pubmed/21338456
  • Peer Reviewed
• [Journal Article] Loss of runt-related transcription factor 3 expression leads hepatocellular carcinoma cells to escape apoptosis (2011)
  • Author(s): Nakanishi Y, Shiraha H, Nakamura S, Nouso K, et al. (他15名)
  • Journal Title: BMC Cancer Volume: 11 Pages: 3-3
  • NAID: 120005053306
  • URL: http://www.ncbi.nlm.nih.gov/pubmed/21205319
  • Peer Reviewed
• [Journal Article] Predicting the treatment effect of sorafenib using serum angiogenesis markers in patients with hepatocellular carcinoma (2011)
  • Author(s): Miyahara K, Nouso K, Nakamura S, Shiraha H, et al. (他10名)
  • Journal Title: J Gastroenterol Hepatol Volume: 26 Pages: 1604-11
  • URL: http://www.ncbi.nlm.nih.gov/pubmed/22011296
  • Peer Reviewed
• [Journal Article] Outcomes after curative treatment for cryptogenic cirrhosis-associated hepatocellular carcinoma satisfying the Milan criteria (2011)
  • Author(s): Takuma Y, Nouso K, Makino Y, et al. (他5名)
  • Journal Title: J Gastroenterol Hepatol Volume: 26 Pages: 1417-24
  • URL: http://www.ncbi.nlm.nih.gov/pubmed/21884248
  • Peer Reviewed
• [Journal Article] Long-term outcome and hepatocellular carcinoma development in chronic hepatitis B or cirrhosis patients after nucleoside analog treatment with entecavir or lamivudine (2011)
  • Author(s): Kobashi H, Nakamura S, Nouso K, et al. (他9名)
  • Journal Title: Hepatol Res Volume: 41 Pages: 405-16
  • NAID: 10031144105
  • Peer Reviewed
• [Journal Article] Predicting the treatment effect of sorafenib using serum angiogenesis markers in patients with hepatocellular carcinoma (2011)
  • Author(s): Miyahara K, Nouso K, Tomoda T, Kobayashi S, Hagihara H, Kuwaki K, Toshimori J, Onishi H, Ikeda F, Miyake Y, Nakamura S, Shiraha H, Takaki A, Yamamoto K
  • Journal Title: J Gastroenterol Hepatol Volume: 26(11) Issue: 11 Pages: 1604-11
  • DOI: 10.1111/j.1440-1746.2011.06887.x
  • Peer Reviewed
• [Journal Article] Percutaneous radiofrequency ablation for treatment of hepatocellular carcinoma in the caudate lobe. (2011)
  • Author(s): Kariyama K, Nouso K, Wakuta A, Kishida M, Nishimura M, Wada N, Higashi T.
  • Journal Title: Am J Roentgenol Volume: 197 Issue: 4 Pages: W571-W575
  • DOI: 10.2214/ajr.11.6893
  • Peer Reviewed
• [Journal Article] Radiofrequency ablation for the treatment of hepatocellular carcinoma with decompensated cirrhosis. (2011)
  • Author(s): Wakuta A, Nouso K, Kariyama K, Nishimura M, Kishida M, Wada N, Mizushima T, Higashi T, Tanimoto M.
  • Journal Title: Oncology Volume: 81 Issue: 1 Pages: 39-44
  • DOI: 10.1159/000331411
  • Peer Reviewed
• [Journal Article] Outcomes after curative treatment for cryptogenic cirrhosis-associated hepatocellular carcinoma satisfying the Milan criteria. (2011)
  • Author(s): Takuma Y, Nouso K, Makino Y, Gotoh T, Toshikuni N, Morimoto Y, Shimomura H, Yamamoto H.
  • Journal Title: J Gastroenterol Hepatol. Volume: 26 Issue: 9 Pages: 1417-1424
  • DOI: 10.1111/j.1440-1746.2011.06775.x
  • Peer Reviewed
• [Journal Article] Long-term outcome and hepatocellular carcinoma development in chronic hepatitis B or cirrhosis patients after nucleoside analog treatment with entecavir or lamivudine. (2011)
  • Author(s): Kobashi H, Miyake Y, Ikeda F, Yasunaka T, Nishino K, Moriya A, Kubota J, Nakamura S, Takaki A, Nouso K, Yamada G, Yamamoto K.
  • Journal Title: Hepatol Res Volume: 41 Issue: 5 Pages: 405-416
  • DOI: 10.1111/j.1872-034x.2011.00785.x
  • NAID: 10031144105
  • Peer Reviewed
• [Journal Article] Prognostic importance of fucosylated alpha-fetoprotein in hepatocellular carcinoma patients with low alpha-fetoprotein (2011)
  • Author(s): Nouso K, Kobayashi Y, Nakamura S, Kobayashi S, Takayama H, Toshimori J, Kuwaki K, Hagihara H, Onishi H, Miyake Y, Ikeda F, Shiraha H, Takaki A, Iwasaki Y, Kobashi H, Yamamoto K
  • Journal Title: J Gastroenterol Hepatol Volume: 26(7) Issue: 7 Pages: 1195-200
  • DOI: 10.1111/j.1440-1746.2011.06720.x
  • Peer Reviewed
• [Presentation] 血管新生関連サイトカインを用いたソラフェニブ/肝動注療法の選択 (2013)
  • Author(s): 宮原孝治、能祖一裕、山本和秀
  • Organizer: 第49回日本肝癌研究会
  • Place of Presentation: 東京
  • Year and Date: 2013-07-11
• [Presentation] 血清糖鎖マーカーによる進行肝細胞癌の予後予測の可能性 (2013)
  • Author(s): 宮原孝治、能祖一裕、中村進一郎、白羽英則, 他
  • Organizer: 第8回日本肝癌分子標的治療研究会
  • Place of Presentation: 石川
  • Year and Date: 2013-06-21
• [Presentation] 血清糖鎖マーカーによる進行肝細胞癌の予後予測の可能性 (2013)
  • Author(s): 宮原孝治、能祖一裕、森本裕貴、和田望、竹内康人、萩原宏明、桑木健志、大西秀樹、中村進一郎、白羽英則、天野麻穂、広瀬和子、西村紳一郎、山本和秀
  • Organizer: 第８回日本肝癌分子標的治療研究会
  • Place of Presentation: 石川
• [Presentation] 膵癌患者における網羅的血清唐鎖解析の臨床応用 (2013)
  • Author(s): 能祖一裕、西村紳一郎、山本和秀
  • Organizer: 第99回日本消化器病学会総会
  • Place of Presentation: 鹿児島
• [Presentation] 肝機能から見た肝癌化学療法の選択 (2013)
  • Author(s): 大西秀樹、能祖一裕、山本和秀
  • Organizer: 第99回日本消化器病学会総会
  • Place of Presentation: 鹿児島
• [Presentation] ソラフェニブ中止後の腫瘍進展に関する検討 (2012)
  • Author(s): 宮原孝治、能祖一裕、中村進一郎、白羽英則, 他
  • Organizer: 第6回日本肝癌分子標的治療研究会
  • Place of Presentation: 神奈川
  • Year and Date: 2012-06-16
• [Presentation] RUNX3の欠失はMRP発現を誘導しgemcitabine感受性に影響を与える (2012)
  • Author(s): 堀口 繁、白羽英則、永原照也、片岡淳朗、岩室雅也、高木章乃夫、能祖一裕、八木孝仁、山本和秀
  • Organizer: 第98回日本消化器病学会総会
  • Place of Presentation: 東京
• [Presentation] 3cm以下3個以内の肝細胞癌に対する肝動脈化学塞栓術後再発リスクの因子 (2012)
  • Author(s): 森元裕貴、能祖一裕、山本和秀
  • Organizer: 第48回日本肝臓学会総会
  • Place of Presentation: 金沢
• [Presentation] 肝細胞癌において、カルボキシラーゼ活性低下は、SPARC発現を誘導し、細胞接着低下、EMT進行を引き起こす (2012)
  • Author(s): 白羽英則、堀口繁、岩室雅也、片岡淳朗、永原照也、高木章乃夫、萩原宏明、桑木健志、大西秀樹、中村進一郎、能祖一裕、山本和秀
  • Organizer: 第48回日本肝臓学会総会
  • Place of Presentation: 金沢
• [Presentation] HCV関連肝細胞癌の遺伝子学的成因についての検討 (2012)
  • Author(s): 竹内康人、池田房雄、森藤由記、萩原宏明、安中哲也、桑木健志、三宅康広、大西秀樹、中村進一郎、白羽英則、高木章乃夫、岩﨑良章、能祖一裕、山本和秀
  • Organizer: 第48回日本肝臓学会総会
  • Place of Presentation: 金沢
• [Presentation] 3㎝以下3個以内の肝細胞癌に対する肝動脈化学寒栓術後再発リスクの因子 (2012)
  • Author(s): 森元裕貴、能祖一裕、山本和秀
  • Organizer: 第48回日本肝臓学会総会
  • Place of Presentation: 金沢
• [Presentation] 進行肝細胞癌に対する肝動脈化学寒栓療法におけるシスプラチン-リピオドール療法とエピルビシン-リピオドール療法の有用性における無作為化比較試験 (2012)
  • Author(s): 小林功幸、能祖一裕、桑木健志、萩原宏明、岩堂昭太、植松周二、大西秀樹、中村進一郎、詫間義隆、宮武宏和、高口浩一、松本栄二、金吉俊彦、歳森淳一、荒木康之、山本和秀
  • Organizer: 第48回日本肝臓学会総会
  • Place of Presentation: 金沢
• [Presentation] ソラフェニブ中止後の腫瘍進展に関する検討 (2012)
  • Author(s): 宮原孝治、能祖一裕、友田 健、小林沙代、萩原宏明、桑木健志、歳森淳一、大西秀樹、中村進一郎、白羽英則、山本和秀
  • Organizer: 第6回 日本肝がん分子標的治療研究会
  • Place of Presentation: 神奈川
• [Presentation] 血管新生関連サイトカインによる進行肝細胞癌の治療効果予測 (2011)
  • Author(s): 宮原孝治、能祖一裕、中村進一郎、白羽英則,他
  • Organizer: 第39回日本肝臓学会西部会
  • Place of Presentation: 岡山
  • Year and Date: 2011-12-09
• [Presentation] 進行肝細胞がんの臨床病態別に見る治療選択 (2011)
  • Author(s): 大西秀樹、能祖一裕、山本和秀
  • Organizer: 第39回日本肝臓学会西部会
  • Place of Presentation: 岡山
  • Year and Date: 2011-12-09
• [Presentation] 血管新生関連サイトカインによるソラフェニブ効果予測 (2011)
  • Author(s): 宮原孝治、能祖一裕、中村進一郎、白羽英則, 他
  • Organizer: 第4回日本肝癌分子標的治療研究会
  • Place of Presentation: 東京
  • Year and Date: 2011-06-18
• [Presentation] 血管新生関連サイトカインによるソラフェニブ効果予測 (2011)
  • Author(s): 宮原孝治、能祖一裕、山本和秀
  • Organizer: JDDW2011
  • Place of Presentation: 福岡
• [Presentation] Evaluation of the treatment effect of Sorafenib by serum NX-PVKA in patients with hepatocellular carcinoma (2011)
  • Author(s): Miyahara K,Nouso K,Kinugasa H,Takeuchi Y,Tomoda T,Kobayashi S, Hagihara H,Yasunaka T,Kuwaki K,Onishi H,Ikeda F,Miyake Y,Nakamura S,Shiraha H, Takaki A,Yamamoto K.
  • Organizer: The 2nd Asia-Pacific Primary Liver Cancer Expert Meeting
  • Place of Presentation: 大阪
• [Presentation] Serum follistatin as a prognostic marker for hepatocellular carcinoma (2011)
  • Author(s): Nouso K, Tomoda T, Kobayashi S, MiyaharaK, Hagihara H, Kuwaki K, Onishi H, Nakamura S, Shiraha H, Takaki A, Yamamoto K
  • Organizer: American association for the study of liver disease
  • Place of Presentation: サンフランシスコ
• [Presentation] Prediction of the occurrence and the recurrence of HCC by SNP in Japanese patients with HCV infection (2011)
  • Author(s): Tomoda T, Nouso K, Sakai A, Takaguchi K, Kobayashi S, Miyahara K, Onishi H, Nakamura S, Yamamoto K
  • Organizer: American association for the study of liver disease
  • Place of Presentation: サンフランシスコ
• [Presentation] Usefulness of serum fucosylated-hemopexin as a biomarker for hepatocellular carcinoma in Japanese patients (2011)
  • Author(s): Kobayashi S, Nouso K, Tomoda T, Miyahara K, Onishi H, Nakamura S, Ikeda F, Miyake Y, Shiraha H, Takaki A, Yamamoto K
  • Organizer: American association for the study of liver disease
  • Place of Presentation: サンフランシスコ
• [Presentation] The impact of polymorphism of patatin-like phospholipase domain-containing protein 3 on prognosis of hepatocellular carcinoma (2011)
  • Author(s): Takeuchi Y, Ikeda F, Moritou Y, Yasunaka T, Kuwaki K, Miyake Y, Ohnishi H, Nakamura S, Shiraha H, Takaki A, Iwasaki Y, Nouso K, Yamamoto K
  • Organizer: American association for the study of liver disease
  • Place of Presentation: サンフランシスコ
• [Book] メタボ肝癌 (2013)
  • Author(s): 能祖一裕
  • Publisher: アークメディア
• [Book] 肝癌診療Q&A (2013)
  • Author(s): 能祖一裕
  • Publisher: 中外医学社