Prediction of the effect of chemotherapy for hepatocellular carcinoma with new parameters
Project/Area Number |
23590976
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Gastroenterology
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Research Institution | Okayama University |
Principal Investigator |
NOUSO Kazuhiro 岡山大学, 医歯(薬)学総合研究科, 准教授 (10314668)
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Co-Investigator(Kenkyū-buntansha) |
SHIRAHA Hidenori 岡山大学, 大学病院, 講師 (40379748)
NAKAMURA Shinichiro 岡山大学, 大学病院, 助教 (70514230)
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Project Period (FY) |
2011 – 2013
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Project Status |
Completed (Fiscal Year 2013)
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Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
Keywords | 肝細胞癌 / 化学療法 |
Research Abstract |
To improve survival of the patients with advanced hepatocellular carcinoma, we tried to establish markers that could predict the efficacy of chemotherapies. By measuring serum 8 cytokines simultaneously, close correlation was observed between high cytokine expressions and poor prognosis. In addition, comprehensive glycan analysis revealed that survival of the patients with high serum tri-antennary glycan (G2890) expression was shorter than that with the low expression.
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Report
(4 results)
Research Products
(75 results)
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[Journal Article] Pro-angiogenic cytokines for prediction of outcomes in patients with advanced hepatocellular carcinoma2013
Author(s)
Miyahara K, Nouso K, Morimoto Y, Takeuchi Y, Hagihara H, Kuwaki K, Onishi H, Ikeda F, Miyake Y, Nakamura S, Shiraha H, Takaki A, Honda M, Kaneko S, Sato T, Sato S, Obi S, Iwadou S, Kobayashi Y, Takaguchi K, Kariyama K, Takuma Y, Takabatake H, Yamamoto K
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Journal Title
Br J Cancer
Volume: 109
Issue: 7
Pages: 2072-2078
DOI
Related Report
Peer Reviewed
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[Journal Article] Evaluation of the effect of sorafenib using serum NX-des-γ-carboxyprothrombin in patients with hepatocellular carcinoma.2013
Author(s)
Miyahara K, Nouso K, Morimoto Y, Tomoda T, Kobayashi S, Takeuchi Y, Hagihara H, Kuwaki K, Ohnishi H, Ikeda F, Miyake Y, Nakamura S, Shiraha H, Takaki A, Yamamoto K
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Journal Title
Hepatol Res.
Volume: 43(10)
Issue: 10
Pages: 1064-70
DOI
Related Report
Peer Reviewed
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[Journal Article] Prognotic impact of serum follistatin in patients with hepatocellular carcinoma.2013
Author(s)
Tomoda T, Nouso K, Miyahara K, Kobayashi S, Kinugasa H, Toyosawa J, Hagihara H, Kuwaki K, Onishi H, Nakamura S, Ikeda F, Miyake Y, Shiraha H, Takaki A, Yamamoto K.
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Journal Title
J Gastroenterol Hepatol.
Volume: 28(8)
Issue: 8
Pages: 1391-6
DOI
Related Report
Peer Reviewed
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[Journal Article] The impact of patatin-like phospholipase domain-containing protein 3 polymorphism on hepatocellular carcinoma prognosis2013
Author(s)
Yasuto Takeuchi, Fusao Ikeda, Yuki Moritou, Hiroaki Hagihara, Tetsuya Yasunaka, Kenji Kuwaki, Yasuhiro Miyake, Hideki Ohnishi, Shinichiro Nakamura, Hidenori Shiraha, Akinobu Takaki, Yoshiaki Iwasaki, Kazuhiro Nouso, Kazuhide Yamamoto
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Journal Title
Journal of Gastroenterology
Volume: 48巻
Issue: 3
Pages: 405-412
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] Measurement of Spleen Stiffness by Acoustic Radiation Force Impulse Imaging Identifies Cirrhotic Patients with Esophageal Varices.2013
Author(s)
Takuma Y, Nouso K, Morimoto Y, Tomokuni J, Sahara A, Toshikuni N, Takabatake H, Shimomura H, Doi A, Sakakibara I, Matsueda K, Yamamoto H.
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Journal Title
Gastroenterology
Volume: 144(1)
Issue: 1
Pages: 92-101
DOI
Related Report
Peer Reviewed
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[Journal Article] Which patients respond best to hepatitis B vaccination after a hepatitis B virus-related liver transplantation?2013
Author(s)
Takaki A, Yagi T, Yasunaka T, Sadamori H, Shinoura S, Umeda Y, Yoshida R, Sato D, Nobuoka D, Utsumi M, Yasuda Y, Nakayama E, Miyake Y, Ikeda F, Shiraha H, Nouso K, Fujiwara T, Yamamoto K.
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Journal Title
J Gastroenterol. 2013
Volume: Feb23
Related Report
Peer Reviewed
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[Journal Article] Risk factors for recurrence after transarterial chemoembolization for early-stage hepatocellular carcinoma.2012
Author(s)
Kinugasa H, Nouso K, Takeuchi Y, Yasunaka T, Onishi H, Nakamura S, Shiraha H, Kuwaki K, Hagihara H, Ikeda F, Miyake Y, Takaki A, Yamamoto K.
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Journal Title
J Gastroenterol.
Volume: 47(4)
Issue: 4
Pages: 421-6
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] Cost-effectiveness analysis on the surveillance for hepatocellular carcinoma in liver cirrhosis patients using contrast-enhanced ultrasonography.2012
Author(s)
Tanaka H, Iijima H, Nouso K, Aoki N, Iwai T, Takashima T, Sakai Y, Aizawa N, Iwata K, Ikeda N, Iwata Y, Enomoto H, Saito M, Imanishi H, Nishiguchi S
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Journal Title
Hepatol Res.
Volume: 42(4)
Issue: 4
Pages: 376-384
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] Runt-related transcription factor 3 reverses epithelial-mesenchymal transition in hepatocellular carcinoma2012
Author(s)
Tanaka S, Shiraha H, Nakanishi Y, Nishina S, Matsubara M, Horiguchi S, Takaoka N, Iwamuro M, Kataoka J, Kuwaki K, Hagihara H, Toshimori J, Ohnishi H, Takaki A, Nakamura S, Nouso K, Yagi T, Yamamoto K
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Journal Title
Int J Cancer
Volume: 131(11)
Issue: 11
Pages: 2537-46
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] Des-γ-carboxyl prothrombin is associated with tumor angiogenesis in hepatocellular carcinoma.2012
Author(s)
Matsubara M, Shiraha H, Kataoka J, Iwamuro M, Horiguchi S, Nishina S, Takaoka N, Uemura M, Takaki A, Nakamura S, Kobayashi Y, Nouso K, Yamamoto K.
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Journal Title
J Gastroenterol Hepatol.
Volume: 27(10)
Issue: 10
Pages: 1602-8
DOI
Related Report
Peer Reviewed
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[Journal Article] Clinical utility of serum fucosylated hemopexin in Japanese patients with hepatocellular carcinoma.2012
Author(s)
Kobayashi S, Nouso K, Kinugasa H, Takeuchi Y, Tomoda T, Miyahara K, Hagihara H, Kuwaki K, Onishi H, Nakamura S, Ikeda F, Miyake Y, Shiraha H, Takaki A, Yamamoto K.
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Journal Title
Hepatol Res.
Volume: 42(12)
Issue: 12
Pages: 1187-95
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] Serum oxidative-anti-oxidative stress balance is dysregulated in patients with hepatitis C virus-related hepatocellular carcinoma.2012
Author(s)
Nishimura M, Takaki A, Tamaki N, Maruyama T, Onishi H, Kobayashi S, Nouso K, Yasunaka T, Koike K, Hagihara H, Kuwaki K, Nakamura S, Ikeda F, Iwasaki Y, Tomofuji T, Morita M, Yamamoto K.
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Journal Title
Hepatol Res.
Volume: Dec20
Issue: 10
Pages: 1078-1092
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] Predicting the treatment effect of sorafenib using serum angiogenesis markers in patients with hepatocellular carcinoma2011
Author(s)
Miyahara K, Nouso K, Tomoda T, Kobayashi S, Hagihara H, Kuwaki K, Toshimori J, Onishi H, Ikeda F, Miyake Y, Nakamura S, Shiraha H, Takaki A, Yamamoto K
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Journal Title
J Gastroenterol Hepatol
Volume: 26(11)
Issue: 11
Pages: 1604-11
DOI
Related Report
Peer Reviewed
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[Journal Article] Long-term outcome and hepatocellular carcinoma development in chronic hepatitis B or cirrhosis patients after nucleoside analog treatment with entecavir or lamivudine.2011
Author(s)
Kobashi H, Miyake Y, Ikeda F, Yasunaka T, Nishino K, Moriya A, Kubota J, Nakamura S, Takaki A, Nouso K, Yamada G, Yamamoto K.
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Journal Title
Hepatol Res
Volume: 41
Issue: 5
Pages: 405-416
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] Prognostic importance of fucosylated alpha-fetoprotein in hepatocellular carcinoma patients with low alpha-fetoprotein2011
Author(s)
Nouso K, Kobayashi Y, Nakamura S, Kobayashi S, Takayama H, Toshimori J, Kuwaki K, Hagihara H, Onishi H, Miyake Y, Ikeda F, Shiraha H, Takaki A, Iwasaki Y, Kobashi H, Yamamoto K
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Journal Title
J Gastroenterol Hepatol
Volume: 26(7)
Issue: 7
Pages: 1195-200
DOI
Related Report
Peer Reviewed
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[Presentation] Evaluation of the treatment effect of Sorafenib by serum NX-PVKA in patients with hepatocellular carcinoma2011
Author(s)
Miyahara K,Nouso K,Kinugasa H,Takeuchi Y,Tomoda T,Kobayashi S, Hagihara H,Yasunaka T,Kuwaki K,Onishi H,Ikeda F,Miyake Y,Nakamura S,Shiraha H, Takaki A,Yamamoto K.
Organizer
The 2nd Asia-Pacific Primary Liver Cancer Expert Meeting
Place of Presentation
大阪
Related Report
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[Presentation] Serum follistatin as a prognostic marker for hepatocellular carcinoma2011
Author(s)
Nouso K, Tomoda T, Kobayashi S, MiyaharaK, Hagihara H, Kuwaki K, Onishi H, Nakamura S, Shiraha H, Takaki A, Yamamoto K
Organizer
American association for the study of liver disease
Place of Presentation
サンフランシスコ
Related Report
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[Presentation] Usefulness of serum fucosylated-hemopexin as a biomarker for hepatocellular carcinoma in Japanese patients2011
Author(s)
Kobayashi S, Nouso K, Tomoda T, Miyahara K, Onishi H, Nakamura S, Ikeda F, Miyake Y, Shiraha H, Takaki A, Yamamoto K
Organizer
American association for the study of liver disease
Place of Presentation
サンフランシスコ
Related Report
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[Presentation] The impact of polymorphism of patatin-like phospholipase domain-containing protein 3 on prognosis of hepatocellular carcinoma2011
Author(s)
Takeuchi Y, Ikeda F, Moritou Y, Yasunaka T, Kuwaki K, Miyake Y, Ohnishi H, Nakamura S, Shiraha H, Takaki A, Iwasaki Y, Nouso K, Yamamoto K
Organizer
American association for the study of liver disease
Place of Presentation
サンフランシスコ
Related Report
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