| Project/Area Number |
23590979
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Kochi University |
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Principal Investigator |
ONO Masafumi 高知大学, 教育研究部医療学系, 講師 (70304681)
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| Co-Investigator(Kenkyū-buntansha) |
SAIBARA Toshiji 高知大学, 教育研究部医療学系, 教授 (60145125)
OCHI Tsunehiro 高知大学, 医学部附属病院, 医員 (30617840)
MUNEKAGE Kensuke 高知大学, 医学部附属病院, 医員 (60617843)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | NASH / kupffer細胞 / 貪食能 / 分化 / サブセット / Kupffer細胞 / サイトカイン / 貪食 / ＴＬＲ２ / ＴＬＲ４ / P.gingivalis / NAFLD / miRNA / アポトーシス |
|---|
| Research Abstract |
Hyper-secretion of inflammatory cytokines from Kupffer cells and impairment of phagocytic function of Kupffer cells are considered to be important pathogenic factors for development of nonalcholic steatohepatitis (NASH). We clarified that number of CD11b+ Kupffer cells which enable to secrete inflammatory cytokines increase, and CD68+ Kupffer cells which enable to phagocyte and production of ROS decrease in NASH livers. In distribution, Kupffer cells distributed on whole hepatic lobes in the livers of NASH unlike normal livers. It was clarified and reported that the changes of subset and the distributions of Kupffer cells would be important pathogenic factors for development of NASH at several domestic and international medical meeting and some articles.
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