Investigation of the pathogenetic factors for the development of NASH
| Project/Area Number |
23590979
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Kochi University |
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Principal Investigator |
ONO Masafumi 高知大学, 教育研究部医療学系, 講師 (70304681)
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| Co-Investigator(Kenkyū-buntansha) |
SAIBARA Toshiji 高知大学, 教育研究部医療学系, 教授 (60145125)
OCHI Tsunehiro 高知大学, 医学部附属病院, 医員 (30617840)
MUNEKAGE Kensuke 高知大学, 医学部附属病院, 医員 (60617843)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | NASH / kupffer細胞 / 貪食能 / 分化 / サブセット / Kupffer細胞 / サイトカイン / 貪食 / ＴＬＲ２ / ＴＬＲ４ / P.gingivalis / NAFLD / miRNA / アポトーシス |
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| Research Abstract |
Hyper-secretion of inflammatory cytokines from Kupffer cells and impairment of phagocytic function of Kupffer cells are considered to be important pathogenic factors for development of nonalcholic steatohepatitis (NASH). We clarified that number of CD11b+ Kupffer cells which enable to secrete inflammatory cytokines increase, and CD68+ Kupffer cells which enable to phagocyte and production of ROS decrease in NASH livers. In distribution, Kupffer cells distributed on whole hepatic lobes in the livers of NASH unlike normal livers. It was clarified and reported that the changes of subset and the distributions of Kupffer cells would be important pathogenic factors for development of NASH at several domestic and international medical meeting and some articles.
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Report
(4 results)
Research Products
(137 results)
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[Journal Article] Hepatocyte destruction with enhanced collagen synthesis: Characteristic feature of chronic hepatitis C patients on haemodialysis2013
Author(s)
Ue, M., Ikebe, N., Munekage, K., Ochi, T., Hirose, A., Kataoka, H., Fujimoto, S., Kikuchi, K., Okuhara, Y., Ono, M.a , Saibara, T.
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Journal Title
Journal of Viral Hepatitis
Volume: 20(6)
Issue: 5
Pages: 350-357
DOI
Related Report
Peer Reviewed
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[Journal Article] Validation of the FIB4 index in a Japanese nonalcoholic fatty liver disease population2012
Author(s)
Sumida Y, Yoneda M, Hyogo H, Itoh Y, Ono M, Fujii H, Eguchi Y, Suzuki Y, Aoki N, Kanemasa K, Fujita K, Chayama K, Saibara T, Kawada N, Fujimoto K, Kohgo Y, Yoshikawa T, Okanoue T, Jsg-Nafld JS
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Journal Title
BMC Gastroenterol
Volume: (Epub)
Issue: 1
Pages: 2-2
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] Involvement of a periodontal pathogen, Porphyromonas gingivalis on the pathogenesis of non-alcoholic fatty liver disease2012
Author(s)
Yoneda M, Naka S, Nakano K, Wada K, Endo H, Mawatari H, Imajo K, Nomura R, Hokamura K, Ono M, Murata S, Tohnai I, Sumida Y, Shima T, Kuboniwa M, Umemura K, Kamisaki Y, Amano A, Okanoue T, Ooshima T, Nakajima A.
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Journal Title
BMC Gastroenterol
Volume: 12
Issue: 1
Pages: 12-16
DOI
Related Report
Peer Reviewed
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[Journal Article] A novel and comprehensive mouse model of human non-alcoholic steatohepatitis with the full range of dysmetabolic and histological abnormalities induced by gold thioglucose and a high-fat diet2011
Author(s)
Ogasawara M, Hirose A, Ono M, Aritake K, Nozaki Y, Takahashi M, Okamoto N, Sakamoto S, Iwasaki S, Asanuma T, Taniguchi T, Urade Y, Onishi S, Saibara T, Oben JA
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Journal Title
Liver Int
Volume: 31
Pages: 542-551
Related Report
Peer Reviewed
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[Journal Article] Platelet count for predicting fibrosis in nonalcoholic fatty liver disease2011
Author(s)
Yoneda M, Fujii H, Sumida Y, Hyogo H, Itoh Y, Ono M, Eguchi Y, Suzuki Y, Aoki N, Kanemasa K, Imajo K, Chayama K, Saibara T, Kawada N, Fujimoto K, Kohgo Y, Yoshikawa T, Okanoue T, Japan Study Group of Nonal coholic Fatty Liver D
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Journal Title
J Gastroenterol
Volume: 46
Issue: 11
Pages: 1300-1306
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] A novel and comprehensive mouse model of human non-alcoholic steatohepatitis with the full range of dysmetabolic and histological abnormalities induced by gold thioglucose and a high-fat diet2010
Author(s)
Ogasawara M, Ogasawara M, Hirose A, Ono M, Aritake K, Nozaki Y, Takahashi M, Okamoto N, Sakamoto S, Iwasaki S, Asanuma T, Taniguchi T, Urade Y, Onishi S, Saibara T, Oben JA
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Journal Title
Liver Int
Volume: 31
Issue: 4
Pages: 542-551
DOI
Related Report
Peer Reviewed
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[Presentation] Glycemic variability is an indepe ndent predictive factor for developm ent of hepatic fibrosis in nonalcoho lic fatty liver disease2013
Author(s)
Ochi T, Hashiba M, Ono M, Hyogo H, I keda Y, Munekage K, Okamoto N, Iwasa ki S, Chayama K, Eguchi Y, Saibara T
Organizer
The 64th Annual Meeting of the American Association for the Study of Liver Diseases
Place of Presentation
Poster,Walter E. Washington convention center(Washington USA)
Related Report
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[Presentation] Alcohol intake is less important as predictive factors for development of fatty liver dise ase compared to obesity,impairment o f glucose metabolism and dyslipidemia2012
Author(s)
Ono M,Eguchi Y,Hyogo H,Takahashi H,Ochi T,Munekage K,Hirose A,Tak ahashi M,Okamoto N,Fujimoto K,Cha yama K,Saibara T
Organizer
The 63rd Annual Meeting of the American Association for the Study of Liver Diseases
Place of Presentation
Poster Sessions,Hynes Convention Center(Boston USA)
Related Report
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[Presentation] Alcohol intake is less important as predictive factors for development of fatty liver dise ase compared to obesity,impairment o f glucose metabolism and dyslipidemia2012
Author(s)
Ono M,Eguchi Y,Hyogo H,Takahashi H,Ochi T,Munekage K,Hirose A,Tak ahashi M,Okamoto N,Fujimoto K,Cha yama K,Saibara T
Organizer
The 63rd Annual Meeting of the Am erican Association for the Study of Liver Diseases
Place of Presentation
Poster,Hynes Convention Center(Boston USA)
Related Report
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[Presentation] Glycemic variability is an independent predictive factor for developm ent of hepatic fibrosis in nonalcoho lic fatty liver disease2011
Author(s)
Ochi T, Hashiba M, Ono M, Hyogo H, I keda Y, Munekage K, Okamoto N, Iwasa ki S, Chayama K, Eguchi Y, Saibara T
Organizer
The 64th Annual Meeting of the American Association for the Study of Liver Diseases
Place of Presentation
Poster,Walter E. Washington convention center(Washington USA)
Related Report
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[Presentation] Three single nucleo tide polymorphisms haplootype of ang iotensinogen gene associated with th e prevalence of Japanese NASH2011
Author(s)
Ono M,Ochi T,Munekage K,Ogasawara M,Hirose A,Nozaki -Fujimura Y,Tak ahashi M,Okamoto N,Iwasaki S,Eguc hi Y,Saibara T
Organizer
46th annual meeting of the European Assoc iation for the Study of the Liver
Place of Presentation
Poster,Internationales Congress Centrum(Berlin Germany)
Related Report
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[Presentation] The decrease of intra-muscular adipose tissue cont ent is an independent target for tr eatment of nonalcoholic steatohepati tis /nonalcoholic fatty liver disease2011
Author(s)
Eguchi Y,Kitajima Y,Ono M,Mizuta T,Ishibashi E,Ozaki I,Oda Y,Ono N,Eguchi T,Anzai K,Iwakiri R,Koi zumi S,Fujimoto K
Organizer
46th annual meeting of the Europe an Association for the Study of the Liver
Place of Presentation
Poster,Internationales Congress Centrum(Berlin Germany)
Related Report
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