Growth control of liver cancer cells by targeting viral-host chimeric transcript resulted from hepatitis B virus integration
Project/Area Number |
23590984
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Gastroenterology
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Research Institution | Kyoto Prefectural University of Medicine |
Principal Investigator |
MINAMI Masahito 京都府立医科大学, 医学(系)研究科(研究院), 講師 (60326220)
|
Project Period (FY) |
2011 – 2013
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Project Status |
Completed (Fiscal Year 2013)
|
Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
Keywords | 肝癌 / B型肝炎ウイルス / ウイルス組み込み / 肝発癌 / 組み込み |
Research Abstract |
Hepatitis B virus (HBV) has been known to be integrated in the host genome in hepatocellular carcinoma. Here, we have clearly demonstrated that HBV integration occurs in chronic hepatitis tissues. These events can cause insertional mutagenesis in integrated genes and influence the transcription of the affected genes. We also found that HBV integration has favorite sites, such as chromosome 3 and common fragile sites, demonstrating that HBV integration is not a random event, but may result in some selection probably by affected genes. These findings suggest that HBV integration causes host genome mutation at early stages of chronic HBV infection preceding hepatocellular carcinoma and may be associated with persisitence and carcinogenesis of affected cells.
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Report
(4 results)
Research Products
(25 results)
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[Journal Article] Efficacy and safety of sorafenib in very elderly patients aged 80 years and older with advanced hepatocellular carcinoma2014
Author(s)
Jo M, Yasui K, Kirishima T, Shima T, Niimi T, Katayama T, Mori T, Funaki J, Sumida Y, Fujii H, Takami S, Kimura H, Mitsumoto Y, Minami M, Yamaguchi K, Yoshinami N, Mizuno M, Sendo R, Tanaka S, Shintani H, Kagawa K, Okanoue T, Itoh Y
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Journal Title
Hepatol Res
Volume: (Epub ahead of print)
Issue: 13
Pages: 1329-38
DOI
Related Report
Peer Reviewed
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[Journal Article] Efficacy and safety of sorafenib in very elderly patients aged 80 years and older with advanced hepatocellular carcinoma.2014
Author(s)
Jo M, Yasui K, Kirishima T, Shima T, Niimi T, Katayama T, Mori T, Funaki J, Sumida Y, Fujii H, Takami S, Kimura H, Mitsumoto Y, Minami M, Yamaguchi K, Yoshinami N, Mizuno M, Sendo R, Tanaka S, Shintani H, Kagawa K, Okanoue T, Itoh Y.
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Journal Title
Hepatol Res
Volume: Epub ahead of print
Related Report
Peer Reviewed
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[Journal Article] The 'donations for decreased ALT (D4D)' prosocial behavior incentive scheme for NAFLD patients.2013
Author(s)
Sumida Y, Yoshikawa T, Tanaka S, Taketani H, Kanemasa K, Nishimura T, Yamaguchi K, Mitsuyoshi H, Yasui K, Minami M, Naito Y, Itoh Y.
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Journal Title
J Public Health (Oxf)
Volume: Epub ahead of print
Related Report
Peer Reviewed
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[Journal Article] Rosuvastatin ameliorates high-fat and high-cholesterol diet-induced nonalcoholic steatohepatitis in rats2013
Author(s)
Okada Y, Yamaguchi K, Nakajima T, Nishikawa T, Jo M, Mitsumoto Y, Kimura H, Nishimura T, Tochiki N, Yasui K, Mitsuyoshi H, Minami M, Kagawa K, Okanoue T, Itoh Y
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Journal Title
Liver Int
Volume: 33
Issue: 2
Pages: 301-311
DOI
Related Report
Peer Reviewed
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[Journal Article] Factors associated with the overall survival of elderly patients with hepatocellular carcinoma.2012
Author(s)
Fujii H, Itoh Y, Ohnishi N, Sakamoto M, Ohkawara T, Sawa Y, Nishida K, Ohkawara Y, Yamaguchi K, Minami M, Okanoue T.
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Journal Title
World Journal of Gastroenterology
Volume: 18
Issue: 16
Pages: 1926-1932
DOI
Related Report
Peer Reviewed
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[Journal Article] Treatment extension may benefit female genotype 1 chronic hepatitis C patients with complete early virological response to peginterferon-alpha-2b and ribavirin combination therapy.2012
Author(s)
Nishimura T, Yamaguchi K, Hashimoto H, Niimi T, Yokomizo C, Fujii H, Minami M, Sakamoto M, Ohnish N, Nagao Y, Okita M, Umemura A, Shima T, Okanoue T, Itoh Y.
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Journal Title
Hepatology Research
Volume: 42
Issue: 10
Pages: 966-873
DOI
Related Report
Peer Reviewed
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[Journal Article] High expression of p300 in HCC predicts shortened overall survival in association with enhanced epithelial mesenchymal transition of HCC cells2011
Author(s)
Yokomizo C, Yamaguchi K, Itoh Y, Nishimura T, Umemura A, Minami M, Yasui K, Mitsuyoshi H, Fujii H, Tochiki N, Nakajima T, Okanoue T, Yoshikawa T
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Journal Title
Cancer Lett
Volume: 310
Issue: 2
Pages: 140-147
DOI
Related Report
Peer Reviewed
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[Journal Article] Oxidative stress is closely associated with tumor angiogenesis of hepatocellular carcinoma2011
Author(s)
Jo M, Nishikawa T, Nakajima T, Okada Y, Yamaguchi K, Mitsuyoshi H, Yasui K, Minami M, Iwai M, Kagawa K, Itoh Y, Yoshikawa T
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Journal Title
J Gastroenterol
Volume: 46
Issue: 6
Pages: 809-821
DOI
Related Report
Peer Reviewed
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[Journal Article] High expression of p300 in HCC predicts shortened overall survival in association with enhanced epithelial mesenchymal transition of HCC cells.2011
Author(s)
Yokomizo C, Yamaguchi K, Itoh Y, Nishimura T, Umemura A, Minami M, Yasui K, Mitsuyoshi H, Fujii H, Tochiki N, Nakajima T, Okanoue T, Yoshikawa T.
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Journal Title
Cancer Lett
Volume: 310
Pages: 140-147
Related Report
Peer Reviewed
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[Book] 肝臓専門医テキスト2013
Author(s)
飯島尋子,南 祐仁,他,共著 日本肝臓学会,編.
Total Pages
497
Publisher
南江堂,東京.
Related Report
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