Pathogenesis of hepatitis B virus in hepatocyte, undetectable in peripheral blood
| Project/Area Number |
23590985
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Osaka City University |
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Principal Investigator |
TAMORI Akihiro 大阪市立大学, 医学(系)研究科(研究院), 准教授 (30291595)
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| Co-Investigator(Kenkyū-buntansha) |
ENOMOTO Masaru 大阪市立大学, 大学院医学研究科, 准教授 (20423874)
MURAKAMI Yoshiki 大阪市立大学, 大学院医学研究科, 准教授 (00397556)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | B型肝炎ウイルス / 再活性化 / 長期予後 / HBV / 遺伝子変異 / 核酸アナログ |
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| Research Abstract |
To elucidate the clinical characteristics of hepatitis B virus reactivation (HBV-R), we performed a prospective long-term study of patients who receive immunosuppressive or cytotoxic therapy. We enrolled 229 patients with anti-HBc. HBV DNA levels were measured every month to 3 months by a real-time PCR method. The mean observation period was 24 months (range: 2-61 months). Entecavir was administered to all of 20 patients with more than 2.1 log/ml of HBV DNA at the enrollment. In HBsAg-negative patients, HBV was reactivated in 3/30 (10%) ML patients treated with rituximab combination therapy, and 5/19 (26%) patients with HSCT. In RA patients, HBV reactivation occurred in 3/88 (3%) patients. Entecavir inhibited HBV amplification and prevented HBV-associated hepatic failure in patients with HBV reactivation. Mutations in the 'a' determinant region with amino acid replacement were detected in 4 of the 8 patients with HBV-R.
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Report
(4 results)
Research Products
(39 results)
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[Journal Article] New susceptibility and resistance HLA-DP alleles to HBV-related diseases identified by a trans-ethnic association study in Asia.2014
Author(s)
Nishida N, Sawai H, Kashiwase K, Minami M, Sugiyama M, Seto WK, Yuen MF, Posuwan N, Poovorawan Y, Ahn SH, Han KH, Matsuura K, Tanaka Y, Kurosaki M, Asahina Y, Izumi N, Kang JK, （省略）, Tokunaga K, and Mizokami M
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Journal Title
PLoS One
Volume: 9
Issue: 2
Pages: e86449-e86449
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] The expression level of miR-18b in hepatocellular carcinoma is associated with the grade of malignancy and prognosis2013
Author(s)
Murakami Y, Tamori A, Itami S, Tanahashi T, Toyoda H, Tanaka M, Wu W, Brojigin N, Kaneoka Y, Maeda A, Kumada T, Kawada N, Kubo S and Kuroda M.
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Journal Title
BMC Cancer
Volume: 13
Issue: 1
Pages: 99-99
DOI
Related Report
Peer Reviewed
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[Journal Article] Entecavir and interferon-α sequential therapy in Japanese patients with hepatitis B e antigen-positive chronic hepatitis B.2012
Author(s)
Enomoto M, Nishiguchi S, Tamori A, Kobayashi S, Sakaguchi H, Shiomi S, Kim SR, Enomoto H, Saito M, Imanishi H, Kawada N.
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Journal Title
J Gastroenterol
Volume: 48
Issue: 3
Pages: 397-404
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] Prospective study of reactivation of hepatitis B virus in patients with rheumatoid arthritis who received immunosuppressive therapy : evaluation of both HBsAg-positive and HBsAg-negative cohorts2011
Author(s)
Tamori A, Koike T, Goto H, Wakitani S, Tada M, Morikawa H, Enomoto M, Inaba M, Nakatani T, Hino M, Kawada N.
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Journal Title
J Gastroenterol
Volume: 46
Issue: 4
Pages: 555-64
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] Prospective study of reactivation of hepatitis B virus in patients with rheumatoid arthritis who received immunosuppressive therapy: evaluation of both HBsAg-positive and HBsAg-negative cohorts.2011
Author(s)
Tamori A, Koike T, Goto H, Wakitani S, Tada M, Morikawa H, Enomoto M, Inaba M, Nakatani T, Hino M, Kawada N
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Journal Title
J Gastroenterol.
Volume: 46
Pages: 556-564
NAID
Related Report
Peer Reviewed
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[Presentation] Clinical characteristics of hepatitis B virus reactivation in a prospective long-term study for patients with hematologic malignancy
Author(s)
Akihiro Tamori, Masayuki Hino, Etsushi Kawamura, Hideki Fujii, Sawako Uchida-Kobayashi, Hiroyasu Morikawa, Hirohisa Nakamae, Masaru Enomoto, Yoshiki Murakami, Norifumi Kawada
Organizer
49th Annual meeting of the European association for the study of the liver
Place of Presentation
London, United Kingdom
Related Report
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