Pathophysiological correlation between fibrogenesis and regeneration in murine liver via Notch/Jagged-1 signal
| Project/Area Number |
23590991
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Hirosaki University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
YUTAKA Inagaki 東海大学, 医学部, 教授 (80193548)
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| Co-Investigator(Renkei-kenkyūsha) |
KATSUO Hozumi 東海大学, 医学部, 准教授 (30246079)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 肝線維化 / Notchシグナル / 肝臓学 |
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| Research Abstract |
To clarify the involvement of Notch signal in the correlation between fibrogenesis and regeneration in the liver, expression of Notch signal was examined by methionine/choline-deficient diet (MCD) model of liver fibrosis. Mice were sacrificed at 2, 4, and 8 weeks after MCD diet started. Hepatic expression of Notch receptors and Notch ligands were investigated by immunoblot. There were no significant differences between MCD group and control group in the expression of Notch signal during the progression of liver fibrosis. In our preliminary data by using conditional Mx/Cre Jagged-1 knockout mice, it was speculated that Notch signal modulates the correlation between fbrogenesis and regeneration in liver fibrosis. However, in MCD model, Notch signal was not involved in hepatic fibogrnesis. By using other liver fibrosis models, further studies are necessary for the elucidation of the role of Notch signal in the fibrogenic process in the liver.
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Report
(4 results)
Research Products
(4 results)
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[Presentation] Kaori Minakawa, Katsuto Hozumi, Isao Okazaki, Shinsaku Fukuda, Yutaka Inagaki. Notch/Jagged-1 signal modulates pathophysiological correlation between fibrogenesis and regeneration in murine liver2011
Author(s)
Kenichiro Mikami, Sachie Nakao, Reiichi Higashiyama, Hiroshi Fukumitsu, Tadashi Moro, Kaori Minakawa, Katsuto Hozumi, Isao Okazaki, Shinsaku Fukuda, Yutaka Inagaki
Organizer
The 62^<nd> Annual Meeting of The American Association for the Study of Liver Disease
Place of Presentation
San Francisco, USA
Year and Date
2011-11-07
Related Report
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