| Project/Area Number |
23590992
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Tokyo Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
HONDA Akira 東京医科大学, 医学部, 教授 (10468639)
IKEGAMI Tadashi 東京医科大学, 医学部, 准教授 (40439740)
MIYAZAKI Teruo 東京医科大学, 医学部, 講師 (60532687)
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| Project Period (FY) |
2011-04-28 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | hepatitis C / liver cisshosis / interferon / metabolic marker / host factor / 内科 / ウイルス / 脂質代謝 / 肝炎 / インターフェロン |
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| Outline of Final Research Achievements |
Present study examined noninvasive metabolic markers in serum by LC-MS/MS system to evaluate host-factor related to the development from hepatitis C to liver cirrhosis. Sera were collected from healthy control, hepatitis C virus (HCV) infected patients, HCV patients with interferon therapy (HCV+IFN) and liver cirrhosis (LC) patients. In the results, the inactivated beta-oxidation and activated choline metabolism in the HCV patients would be largely inverted in the LC patients. In the examined metabolic markers, the influences of IFN therapy on the host-factor could not be detected. The metabolic fluctuations of the host side may suggest to be deeply involved in the progress from chronic hepatitis C to liver cirrhosis.
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