Cyclopedic investigation of genes for NASH-mediated carcinogenesis
| Project/Area Number |
23590996
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Aichi Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NAKAO Haruhisa 愛知医科大学, 医学部, 教授 (60326139)
NAKADE Haruhisa 愛知医科大学, 医学部, 講師 (70431400)
SHIBASUN Daran Karunan 愛知医科大学, 医学部, 助教 (30557096)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | NASH / 肝発癌 / オリゴCGHアレイ / コリン欠乏食 / オリゴＣＧＨアレイ |
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| Research Abstract |
We examined the genes expressions for NASH-related hepatocarcinogenesis induced by choline-deficient L-amino acid-defined (CDAA) diet, using origo-CGH microarray analysis. Forty-eight week CDAA diet iuduced 52 genes expression differences in the liver between CDAA diets and control. These included tumor proliferation-related genes, and HNF1/TCF1, transcriptional regulation genes expressions were chronologically attenuated. NF1 which is known to be related signal transaction, are chronologically decreased. Real time PCR showed that HNF1/TCF1 has a tendency to be decreased by CDAA diet, however, NF1 mRNA expressions in the liver were not changed by CDAA diet. These results produced the gene expression differences between origo-CGH microarray analysis and real time PCR. Further investigations were needed to examine in the future.
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Report
(4 results)
Research Products
(26 results)
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[Journal Article] Risk factors for long-term persistence of serum hepatitis B surface antigen following acute hepatitis B virus infection in Japanese adults.2014
Author(s)
Ito, K., H. Yotsuyanagi, H. Yatsuhashi, Y. Karino, Y. Takikawa, T. Saito, Y. Arase, F. Imazeki, M. Kurosaki, T. Umemura, T. Ichida, H. Toyoda, M. Yoneda, E. Mita, K. Yamamoto, K. Michitaka, T. Maeshiro, J. Tanuma, Y. Tanaka, M. Sugiyama, K. Murata, N. Masaki, M. Mizokami and A. H. B. S. G. Japanese
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Journal Title
Hepatology
Volume: 59
Pages: 89-97
Related Report
Peer Reviewed
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[Journal Article] Angiotensin II type 1 receptor antagonist prevents hepatic carcinoma in rats with nonalcoholic steatohepatitis.2012
Author(s)
Tamaki Y, Nakade Y, Yamauchi T, Makino Y, Yokohama S, Okada M, Aso K, Kanamori H, Ohashi T, Sato K, Nakao H, Haneda M, Yoneda M
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Journal Title
J Gastroenterol
Volume: Aug 14
Pages: 491-503
Related Report
Peer Reviewed
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