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Cyclopedic investigation of genes for NASH-mediated carcinogenesis

Research Project

Project/Area Number 23590996
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Gastroenterology
Research InstitutionAichi Medical University

Principal Investigator

YONEDA Masashi  愛知医科大学, 医学部, 教授 (30261407)

Co-Investigator(Kenkyū-buntansha) NAKAO Haruhisa  愛知医科大学, 医学部, 教授 (60326139)
NAKADE Haruhisa  愛知医科大学, 医学部, 講師 (70431400)
SHIBASUN Daran Karunan  愛知医科大学, 医学部, 助教 (30557096)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
KeywordsNASH / 肝発癌 / オリゴCGHアレイ / コリン欠乏食 / オリゴCGHアレイ
Research Abstract

We examined the genes expressions for NASH-related hepatocarcinogenesis induced by choline-deficient L-amino acid-defined (CDAA) diet, using origo-CGH microarray analysis. Forty-eight week CDAA diet iuduced 52 genes expression differences in the liver between CDAA diets and control. These included tumor proliferation-related genes, and HNF1/TCF1, transcriptional regulation genes expressions were chronologically attenuated. NF1 which is known to be related signal transaction, are chronologically decreased. Real time PCR showed that HNF1/TCF1 has a tendency to be decreased by CDAA diet, however, NF1 mRNA expressions in the liver were not changed by CDAA diet. These results produced the gene expression differences between origo-CGH microarray analysis and real time PCR. Further investigations were needed to examine in the future.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (26 results)

All 2014 2013 2012 2011

All Journal Article (25 results) (of which Peer Reviewed: 19 results) Book (1 results)

  • [Journal Article] Risk factors for long-term persistence of serum hepatitis B surface antigen following acute hepatitis B virus infection in Japanese adults2014

    • Author(s)
      Ito K, Yotsuyanagi H, Yatsuhashi H, Yoneda M, et al.
    • Journal Title

      Hepatology

      Volume: 59 Pages: 89-97

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Combined arsenic trioxide-cisplatin treatment enhances apoptosis in oral squamous cell carcinoma cells2014

    • Author(s)
      Nakaoka T, Ota A, Ono T, Karnan S, et al.
    • Journal Title

      Cell Oncol (Dordr)

      Volume: 37 Pages: 119-29

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Update of the management and prognosis of nonalcoholic fatty liver disease2014

    • Author(s)
      Yoneda m
    • Journal Title

      Nihon Syoukakibyou Gakkai Zasshi

      Volume: 111 Pages: 35-41

    • NAID

      130003383341

    • Related Report
      2013 Annual Research Report
  • [Journal Article] Risk factors for long-term persistence of serum hepatitis B surface antigen following acute hepatitis B virus infection in Japanese adults.2014

    • Author(s)
      Ito, K., H. Yotsuyanagi, H. Yatsuhashi, Y. Karino, Y. Takikawa, T. Saito, Y. Arase, F. Imazeki, M. Kurosaki, T. Umemura, T. Ichida, H. Toyoda, M. Yoneda, E. Mita, K. Yamamoto, K. Michitaka, T. Maeshiro, J. Tanuma, Y. Tanaka, M. Sugiyama, K. Murata, N. Masaki, M. Mizokami and A. H. B. S. G. Japanese
    • Journal Title

      Hepatology

      Volume: 59 Pages: 89-97

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Arsenic upregulates the expression of angiotensin II Type I receptor in mouse aortic endothelial cells2013

    • Author(s)
      Hossain E, Ota A, Takahashi M, Karnan S, et al.
    • Journal Title

      Toxicol Lett

      Volume: 220 Pages: 70-5

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Association between variations in the fat mass and obesity-associated gene and pancreatic cancer risk : a case-control study in Japan2013

    • Author(s)
      Lin Y, Ueda J, Yagyu K, Nakao H, et al.
    • Journal Title

      BMC Cancer

      Volume: 13 Pages: 337-337

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Angiotensin II type 1 receptor antagonist prevents hepatic carcinoma in rats with nonalcoholic steatohepatitis2013

    • Author(s)
      Tamaki Y, Nakade Y, Yamauchi T, et al.
    • Journal Title

      J Gastroenterol

      Volume: 48 Pages: 491-503

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Assessment of the long-term transcriptional activity of a 550-bp-long human beta-actin promoter region2012

    • Author(s)
      Damdindorj L, Karnan S, Ota A, et al.
    • Journal Title

      Plasmid

      Volume: 68 Pages: 195-200

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Simple monitoring of gene targeting efficiency in human somatic cell lines using the PIGA gene2012

    • Author(s)
      Karnan S, Konishi Y, Ota A, et al.
    • Journal Title

      PLoS One

      Volume: 7

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] A system for the measurement of gene targeting efficiency in human cell lines using an antibiotic resistance-GFP fusion gene2012

    • Author(s)
      Konishi Y, Karnan S, Takahashi M, et al.
    • Journal Title

      Biotechniques

      Volume: 53 Pages: 141-52

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Hepatocarcinogenesis in NASH2012

    • Author(s)
      Nakade Y, Sato K, Nakao H, et al.
    • Journal Title

      Gan To Kagaku Ryoho

      Volume: 39 Pages: 693-7

    • Related Report
      2013 Final Research Report
  • [Journal Article] The usefulness of measuring liver stiffness by transient elastography for assessing hepatic fibrosis in patients with various chronic liver diseases.2012

    • Author(s)
      Tamano M, Kojima K, Akima T, Murohisa T, Hashimoto T, Uetake C, Sugaya T, Nakano M, Hiraishi H, Yoneda M
    • Journal Title

      Hepatogastroenterology

      Volume: 59 Pages: 826-30

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Angiotensin II type 1 receptor antagonist prevents hepatic carcinoma in rats with nonalcoholic steatohepatitis.2012

    • Author(s)
      Tamaki Y, Nakade Y, Yamauchi T, Makino Y, Yokohama S, Okada M, Aso K, Kanamori H, Ohashi T, Sato K, Nakao H, Haneda M, Yoneda M
    • Journal Title

      J Gastroenterol

      Volume: Aug 14 Pages: 491-503

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Polaprezinc prevents ongoing thioacetamide-induced liver fibrosis in rats.2012

    • Author(s)
      Kono T, Asama T, Chisato N, Ebisawa Y, Okayama T, Imai K, Karasaki H, Furukawa H, Yoneda M
    • Journal Title

      Life Sci.

      Volume: 16 Pages: 122-30

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] 高齢者における脳腸相関と機能性消化管障害の関連(高齢者の機能性消化器疾患)2012

    • Author(s)
      中出幸臣、米田政志
    • Journal Title

      Geriatric Medicine

      Volume: 50 Pages: 925-928

    • Related Report
      2012 Research-status Report
  • [Journal Article] NASHにおける肝発癌(総説)2012

    • Author(s)
      中出幸臣、佐藤 顕、中尾春壽、米田政志
    • Journal Title

      癌と化学療法

      Volume: 39 Pages: 693-967

    • Related Report
      2012 Research-status Report
  • [Journal Article] 若年者に発症した石灰乳胆汁による閉塞性黄疸に対し、EPBDが奏功した1例2012

    • Author(s)
      足立和規、田中創始、小林佑次、林 伸彦、石井紀光、金澤太茂、佐々木誠人、中尾春壽、春日井邦夫、米田 政志
    • Journal Title

      Gastroenterological Endoscopy

      Volume: 54 Pages: 466-473

    • NAID

      10030294075

    • Related Report
      2012 Research-status Report
  • [Journal Article] ドイツにおける全国的大腸内視鏡スクリーニングプログラムの大腸直腸癌発見に対する効果2012

    • Author(s)
      米田政志
    • Journal Title

      G.I. Research

      Volume: 20 Pages: 498-499

    • Related Report
      2012 Research-status Report
  • [Journal Article] Polaprezinc prevents ongoing thioacetamide-induced liver fibrosis in rats2012

    • Author(s)
      Kono T, Asama T, Chisato N, Ebisawa Y, Okayama T, Imai K, Karasaki H, Furukawa H, Yoneda M
    • Journal Title

      Life Sci

      Volume: 16 Pages: 122-30

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Usefulness of a slow nutrient drinking test for evaluating gastric perception and accommodation2011

    • Author(s)
      Iida A, Konagaya T, Kaneko H, Yoneda M, et al.
    • Journal Title

      Digestion

      Volume: 84 Pages: 253-60

    • Related Report
      2013 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] An overview of genetic polymorphisms and pancreatic cancer risk in molecular epidemiologic studies2011

    • Author(s)
      Lin Y, Yagyu K, Egawa N, Nakao H, et al.
    • Journal Title

      J Epidemiol

      Volume: 21 Pages: 2-12

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Liver stiffness measurement using transient elastography and hepatocellular carcinoma2011

    • Author(s)
      Nakao H, Yoneda M.
    • Journal Title

      Hepatol Res

      Volume: 41 Pages: 921-4

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Liver stiffness measurement using transient elastography and hepatocellular carcinoma.2011

    • Author(s)
      Nakao H, Yoneda M.
    • Journal Title

      Hepatology Research

      Volume: 41 Pages: 921-4

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Association between perceived happiness levels and peripheral circulating pro-inflammatory cytokine levels in middle-aged adults in Japan2011

    • Author(s)
      Matsunaga M, Isowa T, Yamakawa K, Tsuboi H, Kawanishi Y, Kaneko H, Kasugai K, Yoneda M, Ohira H
    • Journal Title

      Neuro Endocrinol Lett

      Volume: 32 Pages: 458-63

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Preventive effect of urinary trypsin inhibitor on the development of liver fibrosis in mice2011

    • Author(s)
      Kono T, Kashiwade Y, Asama T, Chisato N, Ebisawa Y, Yoneda M, Kasai S
    • Journal Title

      Exp Biol Med (Maywood)

      Volume: 236 Pages: 1314-21

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Book] アンギオテンシン受容体拮抗薬(ARB)の有効例.「症例に学ぶNASH/NAFLDの診断と治療」2012

    • Author(s)
      横浜吏郎、米田政志
    • Publisher
      診断と治療社
    • Related Report
      2012 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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