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Translational research focusing on the regulation of proteasome by Gankyrin

Research Project

Project/Area Number 23590998
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Gastroenterology
Research InstitutionKinki University

Principal Investigator

SAKURAI Toshiharu  近畿大学, 医学部, 講師 (90397539)

Co-Investigator(Kenkyū-buntansha) KUDO Masatoshi  近畿大学, 医学部, 教授 (10298953)
Co-Investigator(Renkei-kenkyūsha) FUJITA Jun  京都大学, 医学研究科, 教授 (50173430)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywordsガンキリン / 幹細胞 / 炎症と発癌 / 癌幹細胞 / JNK / EMT
Research Abstract

Liver-specific p38-alpha ablation was found to enhance ROS accumulation, because it reduced the expression ofHSP25. p38-alpha-deficiency also increased the expression of SOX2, c-Jun and Gankyrin and led to enhanced TAA-induced hepatocarcinogenesis. The up-regulation of SOX2 and c-Jun was prevented by administration of the antioxidant butylated hydroxyanisole. The risk of human HCC recurrence is positively correlated with ROS accumulation in the liver. Augmented oxidative stress of liver parenchymal cells may explain the close relationship between liver fibrosis and hepatocarcinogenesis. In addition, expression of CD133, a cancer stem cell marker, was significantly correlated with Gankyrin expression. Gankyrin knockdown decreased the expression of vascular endothelial growth factor (VEGF) and stemness factors such as Nanog and Oct-4 in colorectal and liver cancer cells.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (69 results)

All 2014 2013 2012 2011

All Journal Article (53 results) (of which Peer Reviewed: 51 results,  Open Access: 1 results) Presentation (13 results) Book (3 results)

  • [Journal Article] NOD2 downregulates colonic inflammation by IRF4-mediated inhibition of K63-linked polyubiquitination of RICK and TRAF6.2014

    • Author(s)
      Watanabe T, Asano N, Meng G, Yamashita K, Arai Y, Sakurai T, Kudo M, Fuss IJ, Kitani A, Shimosegawa T, Chiba T, Strober W.
    • Journal Title

      Mucosal Immunol

      Volume: 1 Issue: 6 Pages: 1-1

    • DOI

      10.1038/mi.2014.19

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Molecular Link between Liver Fibrosis and Hepatocellular Carcinoma2013

    • Author(s)
      Sakurai T, Kudo M
    • Journal Title

      Liver Cancer

      Volume: 2 Pages: 365-366

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Reactive Oxygen Species Induce Epigenetic Instability through the Formation of 8-Hydroxydeoxyguanosine in Human Hepatocarcinogenesis2013

    • Author(s)
      Nishida N, Arizumi T, Takita M, Kitai S, Yada N, Hagiwara S, Inoue T, Minami Y, Ueshima K, Sakurai T, Kudo M
    • Journal Title

      Dig Dis

      Volume: 31(5-6) Pages: 459-66

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Hypothermia Protects against Fulminant Hepatitis in Mice by Reducing Reactive Oxygen Species Production2013

    • Author(s)
      Sakurai T, Kudo M, Watanabe T, Itoh K, Higashitsuji H, Arizumi T, Inoue T, Hagiwara S, Ueshima K, Nishida N, Fukumoto M, Fujita J
    • Journal Title

      Dig Dis

      Volume: 31(5-6) Pages: 440-6

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Unique Association between Global DNA Hypomethylation and Chromosomal Alterations in Human Hepatocellular Carcinoma2013

    • Author(s)
      Nishida N, Kudo M, Nishimura T, Arizumi T, Takita M, Kitai S, Yada N, Hagiwara S, Inoue T, Minami Y, Ueshima K, Sakurai T, Yokomichi N, Nagasaka T, Goel A
    • Journal Title

      PLoS One

      Volume: 8(9) Pages: 72312-72312

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Impact of peginterferon alpha-2b and entecavir hydrate combination therapy on persistent viral suppression in patients with chronic hepatitis B2013

    • Author(s)
      Hagiwara S, Kudo M, Osaki Y, Matsuo H, Inuzuka T, Matsumoto A, Tanaka E, Sakurai T, Ueshima K, Inoue T, Yada N, Nishida N
    • Journal Title

      J Med Virol

      Volume: 85(6) Pages: 987-95

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Association of Gankyrin and stemness factor expression in human colorectal cancer2013

    • Author(s)
      Mine H, Sakurai T, Kashida H, Matsui S, Nishida N, Nagai T, Hagiwara S, Watanabe T, Kudo M
    • Journal Title

      Dig Dis Sci

      Volume: 58(8) Pages: 2337-44

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Overexpression of gankyrin in mouse hepatocytes induces hemangioma by suppressing factor inhibiting hypoxia-inducible factor-1 (FIH-1) and activating hypoxia-inducible factor-12013

    • Author(s)
      Liu Y, Higashitsuji H, Higashitsuji H, Itoh K, Sakurai T, Koike K, Hirota K, Fukumoto M, Fujita J
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 432 Pages: 22-7

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] p38αInhibits Liver Fibrogenesis and Consequent Hepatocarcinogenesis by Curtailing Accumulation of Reactive Oxygen Species2013

    • Author(s)
      Sakurai T, Kudo M, Umemura A, He G, Elsharkawy AM, Seki E, Karin M
    • Journal Title

      Cancer Res

      Volume: 73(1) Pages: 215-24

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Heat shock protein 27 expression is inversely correlated with atrophic gastritis and intraepithelial neoplasia2013

    • Author(s)
      Nagata Y, Kudo M, Nagai T, Watanabe T, Kawasaki M, Asakuma Y, Hagiwara S, Nishida N, Matsui S, Kashida H, Sakurai T
    • Journal Title

      Dig Dis Sci

      Volume: 58 Pages: 381-8

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] FGF3/FGF4 amplification and multiple lung metastases in responders to sorafenib in hepatocellular carcinoma2013

    • Author(s)
      Arao T, Ueshima K, Matsumoto K, Nagai T, Kimura H, Hagiwara S, Sakurai T, Haji S, Kanazawa A, Hidaka H, Iso Y, Kubota K, Shimada M, Utsunomiya T, Hirooka M, Hiasa Y, Toyoki Y, Hakamada K, Yasui K, Kumada T, Toyoda H, Sato S, Hisai H, Kuzuya T, Tsuchiya K, Izumi N, Arii S, Nishio K, Kudo M
    • Journal Title

      Hepatology

      Volume: 57 Pages: 1407-15

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Quantification of tumor DNA in serum and vascular invasion of human hepatocellular carcinoma2013

    • Author(s)
      Nishida N, Arizumi T, Takita M, Nagai T, Kitai S, Yada N, Hagiwara S, Inoue T, Minami Y, Ueshima K, Sakurai T, Ida H, Kudo M
    • Journal Title

      Oncology

      Volume: 1 Pages: 82-7

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Usefulness of Contrast-Enhanced Ultrasonography to Evaluate the Post-Treatment Responses of Radiofrequency Ablation for Hepatocellular Carcinoma : Comparison with Dynamic CT2013

    • Author(s)
      Inoue T, Kudo M, Hatanaka K, Arizumi T, Takita M, Kitai S, Yada N, Hagiwara S, Minami Y, Sakurai T, Ueshima K, Nishida N
    • Journal Title

      Oncology

      Volume: 1 Pages: 51-7

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Molecular Link between Liver Fibrosis and Hepatocellular Carcinoma.2013

    • Author(s)
      Sakurai T, Kudo M
    • Journal Title

      Liver Cancer

      Volume: 2 Issue: 3-4 Pages: 365-366

    • DOI

      10.1159/000343851

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hypothermia protects against fulminant hepatitis in mice by reducing reactive oxygen species production.2013

    • Author(s)
      Sakurai T, Kudo M, Watanabe T, Itoh K, Higashitsuji H, Arizumi T, Inoue T, Hagiwara S, Ueshima K, Nishida N, Fukumoto M, Fujita J.
    • Journal Title

      Dig Dis

      Volume: 31 Issue: 5-6 Pages: 440-6

    • DOI

      10.1159/000355242

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] p38α inhibits liver fibrogenesis and consequent hepatocarcinogenesis by curtailing accumulation of reactive oxygen species.2013

    • Author(s)
      Sakurai T, Kudo M, Umemura A, He G, Elsharkawy AM, Seki E, Karin M
    • Journal Title

      Cancer Res

      Volume: 73 Pages: 215-24

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association of Gankyrin and stemness factor expression in human colorectal cancer2013

    • Author(s)
      Mine H, Sakurai T, Kashida H, Matsui S, Nishida N, Nagai T, Hagiwara S, Watanabe T, Kudo M.
    • Journal Title

      Dig Dis Sci

      Volume: 58 Issue: 8 Pages: 2337-44

    • DOI

      10.1007/s10620-013-2627-8

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] FGF3/FGF4 amplification and multiple lung metastases in responders to sorafenib in hepatocellular carcinoma.2013

    • Author(s)
      Arao T, Ueshima K, Matsumoto K, Nagai T, Kimura H, Hagiwara S, Sakurai T, Haji S, Kanazawa A, Hidaka H, Iso Y, Kubota K, Shimada M, Utsunomiya T, Hirooka M, Hiasa Y, Toyoki Y, Hakamada K, Yasui K, Kumada T, Toyoda H, Sato S, Hisai H, Kuzuya T, Tsuchiya K, Izumi N, Arii S, Nishio K, Kudo M.
    • Journal Title

      Hepatology

      Volume: 57 Issue: 4 Pages: 1407-1415

    • DOI

      10.1002/hep.25956

    • Related Report
      2013 Annual Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Association of Gankyrin and stemness factor expression in human colorectal cancer.2013

    • Author(s)
      Mine H, Sakurai T et al
    • Journal Title

      Dig Dis Sci

      Volume: 0 Pages: 0-0

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Overexpression of gankyrin in mouse hepatocytes induces hemangioma by suppressing factor inhibiting hypoxia-inducible factor-1 (FIH-1) and activating hypoxia-inducible factor-12013

    • Author(s)
      Y. Liu, H. Higashitsuji, K. Itoh, T. Sakurai, K. Koike, K. Hirota, M. Fukumoto, J. Fujita
    • Journal Title

      Biochemical and biophysical research communications

      Volume: 432 Issue: 1 Pages: 22-27

    • DOI

      10.1016/j.bbrc.2013.01.093

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] p38α Inhibits Liver Fibrogenesis and Consequent Hepatocarcinogenesis by Curtailing Accumulation of Reactive Oxygen Species.2013

    • Author(s)
      Sakurai T et al
    • Journal Title

      Cancer Res

      Volume: 73 Issue: 1 Pages: 215-224

    • DOI

      10.1158/0008-5472.can-12-1602

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Toll-like receptor activation in basophils contributes to the development of IgG4-related disease.2013

    • Author(s)
      Watanabe T, Yamashita K, Sakurai T, et al
    • Journal Title

      J Gastroenterol

      Volume: 48 Issue: 2 Pages: 247-253

    • DOI

      10.1007/s00535-012-0626-8

    • NAID

      10031156310

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Heat shock protein 27 expression is inversely correlated with atrophic gastritis and intraepithelial neoplasia.2013

    • Author(s)
      Nagata Y, Kudo M, Nagai T, Watanabe T, Kawasaki M, Asakuma Y, Hagiwara S, Nishida N, Matsui S, Kashida H, Sakurai T
    • Journal Title

      Dig Dis Sci.

      Volume: 58 Issue: 2 Pages: 381-388

    • DOI

      10.1007/s10620-012-2342-x

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Quantification of tumor DNA in serum and vascular invasion of human hepatocellular carcinoma.2013

    • Author(s)
      Nishida N, Arizumi T, Takita M, Nagai T, Kitai S, Yada N, Hagiwara S, Inoue T, Minami Y, Ueshima K, Sakurai T et al
    • Journal Title

      Oncology

      Volume: 84 Issue: Suppl. 1 Pages: 82-87

    • DOI

      10.1159/000345895

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Usefulness of contrast-enhanced ultrasonography to evaluate the post-treatment responses of radiofrequency ablation for hepatocellular carcinoma: comparison with dynamic CT.2013

    • Author(s)
      Inoue T, Kudo M, Hatanaka K, Arizumi T, Takita M, Kitai S, Yada N, Hagiwara S, Minami Y, Sakurai T et al
    • Journal Title

      Oncology.

      Volume: 84 Issue: Suppl. 1 Pages: 51-57

    • DOI

      10.1159/000345890

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Risk of Hepatocellular Carcinoma Development in Cases of Hepatitis C Treated by Long-Term, Low-Dose PEG-IFNα-2a2012

    • Author(s)
      Hagiwara S, Sakurai T, Takita M, Ueshima K, Minami Y, Inoue T, Yada N, Kitai S, Nagai T, Hayaishi S, Arizumi T, Nishida N, Kudo M
    • Journal Title

      Dig Dis

      Volume: 30 Pages: 561-7

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Gender differences in the livers of patients with hepatocellular carcinoma and chronic hepatitis C infection2012

    • Author(s)
      Nishida N, Arizumi T, Hayaishi S, Takita M, Kitai S, Yada N, Hagiwara S, Inoue T, Minami Y, Ueshima K, Sakurai T, Ikai I, Kudo M
    • Journal Title

      Dig Dis

      Volume: 30 Pages: 547-53

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Characteristic Pattern of Reactivation of Hepatitis B Virus during Chemotherapy for Solid Cancers2012

    • Author(s)
      Hagiwara S, Sakurai T, Nishina S, Tanaka K, Ikeda M, Ueshima K, Minami Y, Inoue T, Yada N, Kitai S, Takita M, Nagai T, Hayaishi S, Arizumi T, Park AM, Munakata H, Nishida N, Kudo M
    • Journal Title

      Dig Dis

      Volume: 30 Pages: 541-6

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification of a novel enhancer that binds Sp1 and contributes to induction of cold-inducible RNA-binding protein (cirp) expression in mammalian cells2012

    • Author(s)
      Sumitomo Y, Higashitsuji H, Higashitsuji H, Liu Y, Fujita T, Sakurai T, Candeias MM, Itoh K, Chiba T, Fujita J
    • Journal Title

      BMC Biotechnol

      Volume: 12 Pages: 72-72

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cold-inducible RNA-binding protein (Cirp) interacts with Dyrk1b/Mirk and promotes proliferation of immature male germ cells in mice2012

    • Author(s)
      Masuda T, Itoh K, Higashitsuji H, Higashitsuji H, Nakazawa N, Sakurai T, Liu Y, Tokuchi H, Fujita T, Zhao Y, Nishiyama H, Tanaka T, Fukumoto M, Ikawa M, Okabe M, Fujita J
    • Journal Title

      Proc Natl Acad Sci U S A

      Volume: 109 Pages: 10885-90

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Toll-like receptor activation in basophils contributes to the development of IgG4-related disease2012

    • Author(s)
      Watanabe T, Yamashita K, Sakurai T, Kudo M, Shiokawa M, Uza N, Kodama Y, Uchida K, Okazaki K, Chiba T
    • Journal Title

      J Gastroenterol

      Volume: 48 Pages: 247-53

    • NAID

      10031156310

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Activation of JNK and High Expression Level of CD133 Predict a Poor Response to Sorafenib in Hepatocellular Carcinoma2012

    • Author(s)
      Hagiwara S, Kudo M, Nagai T, Inoue T, Ueshima K, Nishida N, Watanabe T, Sakurai T
    • Journal Title

      Br J Cancer

      Volume: 106 Pages: 1997-2003

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] p38MAPK suppresses chronic pancreatitis by regulating HSP27 and BAD expressions2012

    • Author(s)
      Park AM, Kudo M, Hagiwara S, Tabuchi M, Watanabe T, Munakata H, Sakurai T
    • Journal Title

      Free Radical Biol Med

      Volume: 52 Pages: 2284-2291

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Assessment of Gd-EOB-DTPA-enhanced MRI for HCC and dysplastic nodules and comparison of detection sensitivity versus MDCT2012

    • Author(s)
      Inoue T, Kudo M, Komuta M, Hayaishi S, Ueda T, Takita M, Kitai S, Hatanaka K, Yada N, Hagiwara S, Chung H, Sakurai T, Ueshima K, Sakamoto M, Maenishi O, Hyodo T, Okada M, Kumano S, Murakami T
    • Journal Title

      J Gastroenterol

      Volume: 47(9) Pages: 1036-47

    • NAID

      10031122091

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Activation of JNK in the non-cancerous liver tissue predicts a high risk of recurrence after hepatic resection2012

    • Author(s)
      Hagiwara S, Kudo M, Chung H, Ueshima K, Haji S, Watanabe T, Park AM, Munakata H, Sakurai T
    • Journal Title

      Hepatol Res

      Volume: 42 Pages: 394-400

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Munakata H, Sakurai T. Activation of c-Jun N-terminal kinase in non-cancerous liver tissue predicts a high risk of recurrence after hepatic resection for hepatocellular carcinoma2012

    • Author(s)
      Hagiwara S, Kudo M, Chung H, Ueshima K, Inoue T, Haji S, Watanabe T, Park AM,
    • Journal Title

      Hepatol Res.

      Volume: 42(4) Issue: 4 Pages: 394-400

    • DOI

      10.1111/j.1872-034x.2011.00932.x

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] p38MAPK suppresses chronic pancreatitis by regulating HSP27 and BAD expression2012

    • Author(s)
      Park AM, Kudo M, Hagiwara S, Tabuchi M, Watanabe T, Munakata H, Sakurai T.
    • Journal Title

      Free Radic Biol Med

      Volume: 52(11-12) Issue: 11-12 Pages: 2284-91

    • DOI

      10.1016/j.freeradbiomed.2012.03.010

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Activation of JNK and high expression level of CD133 predict a poor response to sorafenib in hepatocellular carcinoma.2012

    • Author(s)
      Hagiwara S, Kudo M, Nagai T, Inoue T, Ueshima K, Nishida N, Watanabe T, Sakurai T.
    • Journal Title

      Br J Cancer.

      Volume: 106 Issue: 12 Pages: 1997-2003

    • DOI

      10.1038/bjc.2012.145

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Cold-inducible RNA-binding protein (Cirp) interacts with Dyrk1b/Mirk and promotes proliferation of immature male germ cells in mice2012

    • Author(s)
      Masuda T, et al.
    • Journal Title

      Proc Natl Acad Sci USA

      Volume: 109 Issue: 27 Pages: 10885-108901

    • DOI

      10.1073/pnas.1121524109

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Identification of a novel enhancer that binds Sp1 and contributes to induction of cold-inducible RNA-binding protein (cirp) expression in mammalian cells.2012

    • Author(s)
      Sumitomo Y, Higashitsuji H, Higashitsuji H, Liu Y, Fujita T, Sakurai T, et al
    • Journal Title

      BMC Biotechnol

      Volume: 12 Issue: 1 Pages: 72-72

    • DOI

      10.1186/1472-6750-12-72

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Case of Peutz-Jeghers syndrome with depressed-type early duodenal carcinoma.2012

    • Author(s)
      Sakurai T et al
    • Journal Title

      Dig Endosc

      Volume: 24 Issue: 6 Pages: 489-489

    • DOI

      10.1111/j.1443-1661.2012.01361.x

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Assessment of Gd-EOB-DTPA-enhanced MRI for HCC and dysplastic nodules and comparison of detection sensitivity versus MDCT.2012

    • Author(s)
      Inoue T, Kudo M, Komuta M, Hayaishi S, Ueda T, Takita M, Kitai S, Hatanaka K, Yada N, Hagiwara S, Chung H, Sakurai T, et al
    • Journal Title

      J Gastroenterol

      Volume: 47 Issue: 9 Pages: 1036-1047

    • DOI

      10.1007/s00535-012-0571-6

    • NAID

      10031122091

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Characteristic pattern of reactivation of hepatitis B virus during chemotherapy for solid cancers.2012

    • Author(s)
      Hagiwara S, Sakurai T et al
    • Journal Title

      Dig Dis

      Volume: 30 Issue: 6 Pages: 541-546

    • DOI

      10.1159/000343056

    • Related Report
      2012 Research-status Report
  • [Journal Article] Risk of hepatocellular carcinoma development in cases of hepatitis C treated by long-term, low-dose PEG-IFNα-2a.2012

    • Author(s)
      Nishida N, Arizumi T, Hayaishi S, Takita M, Kitai S, Yada N, Hagiwara S, Inoue T, Minami Y, Ueshima K, Sakurai T,
    • Journal Title

      Dig Dis

      Volume: 30 Issue: 6 Pages: 547-553

    • DOI

      10.1159/000343057

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Activation of JNK in the non-cancerous liver tissue predicts a high risk of recurrence after hepatic resection.2012

    • Author(s)
      Sakurai T
    • Journal Title

      Hepatol Res

      Volume: 42 Pages: 394-400

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Activation of Toll-like receptors and NOD-like receptors is involved in enhanced IgG4 responses in autoimmune pancreatitis.2012

    • Author(s)
      Watanabe T, Yamashita K, Fujikawa S, Sakurai T, Kudo M, Shiokawa, M, Kodama Y, Uchida K, Okazaki K, Chiba T.
    • Journal Title

      Arthritis & Rheumatism

      Volume: 64 Issue: 3 Pages: 914-24

    • DOI

      10.1002/art.33386

    • NAID

      40019474430

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Adriamycin Enhances Proteasome-Mediated Generation of the Proapoptotic Processed Form of MAGE-A4 in Hepatoma Cells2011

    • Author(s)
      Sakurai T, Kudo M, Itoh K, Ryu U, Higashitsuji H, Fujita J
    • Journal Title

      Oncology

      Volume: 81 (Suppl 1) Pages: 30-5

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Signaling pathways governing tumor angiogenesis2011

    • Author(s)
      Sakurai T, Kudo M
    • Journal Title

      Oncology

      Volume: 81 (Suppl 1) Pages: 24-9

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Association of interleukin-28B and hepatitis C genotype 1 with a high viral load and response to pegylated interferon plus ribavirin therapy2011

    • Author(s)
      Sakurai T, Kudo M
    • Journal Title

      Digestion

      Volume: 84 (Suppl 1) Pages: 56-61

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of activation of toll-like receptors and NOD-like receptors is involved in enhanced IgG4 responses in autoimmune pancreatitis2011

    • Author(s)
      Watanabe T, Yamashita K, Fujikawa S, Sakurai T, Kudo M, Shiokawa M, Kodama Y, Uchida K, Okazaki K, Chiba T
    • Journal Title

      Arthritis Rheum

      Volume: 64 Pages: 914-24

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Des-γ-Carboxyprothrombin May Be a Promising Biomarker to Determine the Therapeutic Efficacy of Sorafenib for Hepatocellular Carcinoma2011

    • Author(s)
      Ueshima K, Kudo M, Takita M, Nagai T, Tatsumi C, Ueda T, Kitai S, Ishikawa E, Yada N, Inoue T, Hagiwara S, Minami Y, Chung H, Sakurai T
    • Journal Title

      Digestion

      Volume: 29 Pages: 321-325

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of angiotensin II and reactive oxygen species in pancreatic fibrosis2011

    • Author(s)
      Sakurai T, Kudo M, Fukuta N, Nakatani T, Kimura M, Park AM, Munakata H
    • Journal Title

      Pancreatology

      Volume: 11 (suppl 2) Pages: 7-13

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Signaling pathways governing tumor angiogenesis.2011

    • Author(s)
      Sakurai T
    • Journal Title

      Oncology

      Volume: 81 Pages: 24-29

    • Related Report
      2011 Research-status Report
  • [Presentation] 肝発癌および治療抵抗性獲得における幹細胞の役割2013

    • Author(s)
      櫻井俊治, 他
    • Organizer
      Japan Digestive Disease Week 2013ワークショップ
    • Place of Presentation
      東京
    • Year and Date
      2013-10-11
    • Related Report
      2013 Final Research Report
  • [Presentation] 大腸発癌における幹細胞の制御機構2013

    • Author(s)
      櫻井俊治, 他
    • Organizer
      日本消化器癌発生学会総会シンポジウム
    • Place of Presentation
      金沢
    • Year and Date
      2013-09-05
    • Related Report
      2013 Final Research Report
  • [Presentation] 胃粘膜上皮のHSPA27発現は上皮内癌の発生リスクと負の相関を示す2013

    • Author(s)
      永田嘉昭、櫻井俊治, 他
    • Organizer
      第99回日本消化器病学会総会
    • Place of Presentation
      鹿児島
    • Year and Date
      2013-03-23
    • Related Report
      2013 Final Research Report
  • [Presentation] 慢性膵炎におけるp38MAPK, HSPA27の役割2013

    • Author(s)
      櫻井俊治, 他
    • Organizer
      第99回日本消化器病学会総会
    • Place of Presentation
      鹿児島
    • Year and Date
      2013-03-21
    • Related Report
      2013 Final Research Report
  • [Presentation] 肝発癌および治療抵抗性獲得における幹細胞の役割2013

    • Author(s)
      櫻井俊治
    • Organizer
      Japan Digestive Disease Week 2013
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
  • [Presentation] 大腸発癌における幹細胞の制御機構2013

    • Author(s)
      櫻井俊治
    • Organizer
      日本消化器癌発生学会総会
    • Place of Presentation
      金沢
    • Related Report
      2013 Annual Research Report
  • [Presentation] 慢性膵炎におけるp38MAPK, HSP27の役割2013

    • Author(s)
      櫻井俊治、その他
    • Organizer
      第99回日本消化器病学会総会
    • Place of Presentation
      城山観光ホテル, かごしま県民交流センター, 鹿児島
    • Related Report
      2012 Research-status Report
  • [Presentation] 胃粘膜上皮のHSP27発現は上皮内癌の発生リスクと負の相関を示す2013

    • Author(s)
      永田嘉昭、櫻井俊治、その他
    • Organizer
      第99回日本消化器病学会総会
    • Place of Presentation
      城山観光ホテル, かごしま県民交流センター, 鹿児島
    • Related Report
      2012 Research-status Report
  • [Presentation] ソラフェニブ治療におけるJNK活性の重要性-CD133との関連も含めて-2013

    • Author(s)
      萩原智、櫻井俊治、工藤正俊
    • Organizer
      第7回日本肝がん分子標的治療研究会
    • Place of Presentation
      じゅうろくプラザ, 岐阜
    • Related Report
      2012 Research-status Report
  • [Presentation] Activation of JNK in the non-cancerous liver tissue predicts a high risk of recurrence after hepatic resection for hepatocellular carcinoma2012

    • Author(s)
      櫻井俊治, 他
    • Organizer
      Digestive Disease Week 2012
    • Place of Presentation
      米国サンディエゴ
    • Year and Date
      2012-05-21
    • Related Report
      2013 Final Research Report
  • [Presentation] Activation of JNK in the Non-cancerous liver tissue predicts a high risk of recurrence after hepatic resection for hepatocellular carcinoma2012

    • Author(s)
      櫻井俊治、その他
    • Organizer
      Digestive Disease Week(DDW) 2012
    • Place of Presentation
      San Diego, USA
    • Related Report
      2012 Research-status Report
  • [Presentation] 肝細胞癌治療におけるJNK活性の重要性2011

    • Author(s)
      萩原智、櫻井俊治、工藤正俊
    • Organizer
      日本肝臓学会総会シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2011-06-02
    • Related Report
      2013 Final Research Report
  • [Presentation] 肝細胞癌治療におけるJNK活性の重要性2011

    • Author(s)
      萩原智
    • Organizer
      日本肝臓学会 総会 シンポジウム
    • Place of Presentation
      東京(ホテルグランパシフィック)
    • Related Report
      2011 Research-status Report
  • [Book] シグナル伝達異常とバイオマーカー探索2012

    • Author(s)
      櫻井俊治, 他
    • Publisher
      The Liver Cancer Journal
    • Related Report
      2013 Final Research Report
  • [Book] トップランナーに聞く2011

    • Author(s)
      櫻井俊治, 他
    • Publisher
      最新医学社
    • Related Report
      2013 Final Research Report
  • [Book] 最新医学2011

    • Author(s)
      櫻井俊治
    • Total Pages
      4
    • Publisher
      最新医学社
    • Related Report
      2011 Research-status Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

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