| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Research Abstract |
The Wnt signaling pathway plays a major role in development and carcinogenesis. Its downstream gene expressions occur through T-cell factor (TCF) proteins. We previously identified and cloned 14 human TCF-4 isoforms, and focused on function of the unique motif SxxSS in the isoforms. In our three-year study, we have demonstrated that loss of the SxxSS motif in a TCF-4 isoform confers hypoxia resistance to liver cancer cells, possibly resulting in augmented tumorigenesis. One of the underlying mechanisms was increased expression levels of HIF-2alpha through down-regulated expression of VHL.
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