Human T-Cell factor-4 isoform promotes tumorigenicity in a hypoxia-dependent manner
| Project/Area Number |
23590999
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Gastroenterology
|
|---|
| Research Institution | Kurume University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2011 – 2013
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
|
|---|
| Keywords | 肝臓学 / Wntシグナル / 低酸素 / TCF / Wnt / TCF-4 / HIF / リン酸化 |
|---|
| Research Abstract |
The Wnt signaling pathway plays a major role in development and carcinogenesis. Its downstream gene expressions occur through T-cell factor (TCF) proteins. We previously identified and cloned 14 human TCF-4 isoforms, and focused on function of the unique motif SxxSS in the isoforms. In our three-year study, we have demonstrated that loss of the SxxSS motif in a TCF-4 isoform confers hypoxia resistance to liver cancer cells, possibly resulting in augmented tumorigenesis. One of the underlying mechanisms was increased expression levels of HIF-2alpha through down-regulated expression of VHL.
|
Report
(4 results)
Research Products
(50 results)
-
[Journal Article] CD34+ cell therapy is safe and effective in slowing the decline of hepatic reserve function in patients with decompensated liver cirrhosis2014
Author(s)
Nakamura T, Torimura T, Iwamoto H, Kurogi J, Inoue H, Hori Y, Sumie S, Fukushima N, Sakata M, Koga H, et al.
-
Journal Title
J Gastroenterol Hepatol
Volume: (in press)
Issue: 10
Pages: 1830-1838
DOI
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
