Unraveling the role of Angptl2 in the pathogenesis of steatohepatitis and liver cancer
| Project/Area Number |
23591001
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | National Defense Medical College |
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Principal Investigator |
TOMITA Kengo 防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究, 病院, 講師 (50317129)
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| Co-Investigator(Kenkyū-buntansha) |
SEKI Shuji 防衛医科大学校, 医学教育部医学科専門課程, 教授 (80531392)
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| Co-Investigator(Renkei-kenkyūsha) |
OIKE Yuichi 熊本大学, 大学院, 教授 (90312321)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | 非アルコール性脂肪肝炎 / 肝臓線維化 / 肝臓癌 / Angptl2 |
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| Research Abstract |
Angiopoietin-like protein 2 (Angptl2) is an adipocytokine, which induces chemotaxis of macrophages to adipose tissue, exaggerates adipose tissue inflammation, and aggravates insulin resistance and obesity. Nonalcoholic steatohepatitis (NASH) is thought to be a hepatic manifestation of metabolic syndrome. Therefore, Angptl2 may play an important role in the pathogenesis of NASH and NASH-related liver cancer. In the present study, we tried to unravel the role of Angptl2 in the progression of NASH and NASH-related liver cancer, using Angptl2-deficient mice and human liver samples in patients with NASH or liver cancer. We intend to promote necessary study and research for clinical application.
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Report
(4 results)
Research Products
(33 results)
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[Journal Article] Free cholesterol accumulation in hepatic stellate cells: Mechanism of liver fibrosis aggravation in nonalcoholic steatohepatitis in mice2014
Author(s)
Tomita, K. Teratani, T. Suzuki, T. Shimizu, M. Sato, H. Narimatsu, K. Okada, Y. Kurihara, C. Irie, R. Yokoyama, H. Shimamura, K. Usui, S. Ebinuma, H. Saito, H. Watanabe, C. Komoto, S. Kawaguchi, A. Nagao, S. Sugiyama, K. Hokari, R. Kanai, T. Miura, S. Hibi, T.
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Journal Title
Hepatology
Volume: 59
Issue: 1
Pages: 154-169
DOI
Related Report
Peer Reviewed
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[Journal Article] Acyl-CoA:cholesterol acyltransferase 1 mediates liver fibrosis by regulating free cholesterol accumulation in hepatic stellate cells.2014
Author(s)
Tomita K, Teratani T, Suzuki T, Shimizu M, Sato H, Narimatsu K, Usui S, Furuhashi H, Kimura A, Nishiyama K, Maejima T, Okada Y, Kurihara C, Shimamura K, Ebinuma H, Saito H, Yokoyama H, Watanabe C, Komoto S, Nagao S, Sugiyama K, Aosasa S, Hatsuse K, Yamamoto J, Hibi T, Miura S, Hokari R, Kanai T.
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Journal Title
Journal of Hepatology
Volume: 印刷中
Issue: 1
Pages: 98-106
DOI
Related Report
Peer Reviewed
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[Journal Article] C-C motif chemokine receptor 9 positive macrophages activate hepatic stellate cells and promote liver fibrosis in mice.2013
Author(s)
Chu PS, Nakamoto N, Ebinuma H, Usui S, Saeki K, Matsumoto A, Mikami Y, Sugiyama K, Tomita K, Kanai T, Saito H, Hibi T.
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Journal Title
Hepatology
Volume: 58
Issue: 1
Pages: 337-350
DOI
Related Report
Peer Reviewed
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[Journal Article] p53/p66Shc-mediated signaling contributes to the progression of non-alcoholic steatohepatitis in humans and mice.2012
Author(s)
Tomita K, Teratani T, Shimamura K, Nishiyama N, Mataki R, Irie T, Minamino Y, Okada C, Kurihara H, Sugiyama K, et al
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Journal Title
J Hepatol
Volume: 57
Issue: 4
Pages: 837-843
DOI
Related Report
Peer Reviewed
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[Journal Article] A high-cholesterol diet exacerbates liver fibrosis in mice via accumulation of free cholesterol in hepatic stellate cells2012
Author(s)
Teratani T, Tomita K, Suzuki T, Oshikawa T, Yokoyama H, Shimamura K, Tominaga S, Hiroi S, Irie R, Okada Y, Kurihara C, Ebinuma H, Saito H, Hokari R, Sugiyama K, Kanai T, Miura S, Hibi T
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Journal Title
Gastroenterology
Volume: 142
Issue: 1
Pages: 152-164
DOI
Related Report
Peer Reviewed
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[Presentation] The characteristic Mechanisms of Free Cholesterol Accumulation in Hepatic Stellate Cells Aggravate liver fibrosis in Nonalcoholic Steatohepatitis in Mice2013
Author(s)
Tomita K, Teratani T, Suzuki T, Yokoyama H, Shimamura K, Nishiyama K, Okada Y, Kurihara C, Ebinuma H, Saito H, Hokari R, Sugiyama K, Hatsuse K, Yamamoto J, Kanai T, Hibi T, Miura S.
Organizer
The 48th Annual Meeting of the European Associatiion for the Study of Liver Diseases
Place of Presentation
オランダ アムステルダム
Related Report
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[Presentation] p53/p66Shc signaling pathway plays a role in nonalcoholic steatohepatitis progression in human and mice.2012
Author(s)
Tomita K, Teratani T, Suzuki T, Yokoyama H, Shimamura K, Nishiyama K, Okada Y, Kurihara C, Ebinuma H, Saito H, Hokari R, Sugiyama K, Hatsuse K, Yamamoto J, Kanai T, Hibi T, Miura S
Organizer
The 47th Annual Meeting of the European Associatiion for the Study of Liver Diseases
Place of Presentation
スペイン バルセロナ
Related Report
